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35 results about "Calpain inhibitors" patented technology

Aza-peptide epoxides

ActiveUS20060172952A1Modulate immune systemReduce displayBiocideNervous disorderHuntingtons choreaDemyelinating Disorder
Methods for treatment and / or prevention of nerve degeneration in mammals using aza-peptide epoxide caspase inhibitors are provided. Aspects of the present disclosure include aza-peptide epoxide compositions to treat or prevent diseases, for example stroke, Alzheimer's disease, Parkinson's disease, multiple sclerosis, neuropathies, Huntington's disease, dentatorubropallidoluysian atrophy, spinocerebellar atrophies, spinal bulbar muscular atrophy, diabetes, amyotrophic lateral sclerosis and other motor neuron diseases. The disclosed methods can be used in combination with calpain inhibitors to treat disease or pathological conditions related to the activity of caspases and calpain associated with a specific disease or condition. Such treatable conditions include stroke, Alzheimer's disease, Parkinson's disease, multiple sclerosis, neuropathies, Huntington's disease, dentatorubropallidoluysian atrophy, spinocerebellar atrophies, spinal bulbar muscular atrophy, nerve degeneration associated with diabetes, amyotrophic lateral sclerosis and other motor neuron diseases, nerve degeneration secondary to primary demyelinating disorders, among others.
Owner:EMORY UNIVERSITY +1

Isoform-specific calpain inhibitors, methods of identification, and uses thereof

Molecules that selectively inhibit or stimulate the activity of isoforms of calpains are presented. Methods for screening and characterizing such molecules are also presented. Specific functions of calpain-1 calpain-2 in long term potentiation (LTP), learning and memory, neurodegeneration and diseases of synaptic dysfunction are characterized using novel calpain inhibitors, substrates and related methods. The compounds, compositions, and methods described herein are expected to be useful, for treating neurodegenerative diseases and other diseases of synaptic function, and for modulating cognition in patients in need thereof.
Owner:WESTERN UNIV OF HEALTH SCI

Novel Cysteine Protease Inhibitors and Uses Thereof

ActiveUS20150045393A1Increasing long-term potentiationEnhance memoryBiocideNervous disorderHIV Protease InhibitorBiochemistry
The invention provides for novel cysteine protease inhibitors and compositions comprising novel cysteine protease derivatives. The invention further provides for methods for treatment of neurodegenerative diseases comprising administration novel cysteine protease inhibitors or compositions comprising novel cysteine protease inhibitors. In some embodiments, the cysteine protease inhibitors are calpain inhibitors.
Owner:THE BOARD OF TRUSTEES OF THE UNIV OF ILLINOIS +1

Multiple layer article with interactive reinforcements linear ribbon fiber reinforcement for composite forms

A method and composition are provided to treat traumatic brain injury and inhibit the cascade of secondary injury neuronal damage in a patient following traumatic brain injury. The method and composition are especially advantageous for immediate treatment at the situs of the traumatic brain injury. The method includes treating the traumatic brain injury by administering at least one effective dose of a peptidomimetic calpain inhibitor to the upper one-third of the patients nasal cavity, thereby enabling the at least one effective dose of peptidomimetic calpain inhibitor to bypass the patients blood-brain barrier and delivering the at least one effective dose of peptidomimetic calpain inhibitor to the patients central nervous system. The composition includes at least one effective dose of a peptidomimetic calpain inhibitor having a synthetic peptide of SEQ ID NOS: 2, 3, 5, 6, 7, 8, 9, or 10.
Owner:NEUROTHERANOSTICS INC

Novel hypolipidemic effect of piperine

The invention discloses a novel hypolipidemic effect of piperine. The piperine significantly reduces serum total cholesterol TC, total triglyceride TG and low density lipoprotein cholesterol LDL-C levels in lipid-loaded ICR mice; the piperine concentration-dependently increases cholesterol efflux from human THP-1 macrophages, specifically upregulates ABCA1 protein levels, and acts similarly to calpeptin, a calpain inhibitor. The upregulation of the protein levels of ABCA1 by the piperine is achieved by inhibiting the activity of total calpain in cells. The piperine has the beneficial effect ofproviding a theoretical basis for further development of the piperine as a blood fat reducing medicament or a health food.
Owner:QINGDAO UNIV
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