The invention discloses a new traditional Chinese medicine combination and a preparation method for malaise, palpitation and insomnia treatment; the traditional Chinese medicine combination includes the following source medicines: prepared rehmannia root, angelica, white paeony root, donkey-hide gelatin, the fruit of Chinese wolfberry, unprepared radix astragali, ginseng, radix codonopsis pilosulae, Chinese yam, rhizoma acori graminei, benzoin, storax, holy basil, spina date seed, semen boitae, cortex albiziae, polygala tenuifolia, amber, dragon's bones, oyster, the root of red-rooted salvia, leonurus, ligusticum wallichii, frankincense, myrrh, rhizoma corydalis, costustoot, rhizoma cyperi, immature bitter orange, radix curcumae, medicated leaven, agilawood and the root of three-nerved spicebush and the like. The traditional Chinese medicine combination can be prepared into any type of common oral preparation according to the conventional traditional Chinese medicine preparation method. The invention can significantly improve the symptoms of malaise, palpitation and insomnia, and also has definite clinical curative effect, significant curative and quick effect. As the traditional Chinese medicine combination basically combines medicinal and edible medicine sources specified in the National Formulary, the traditional Chinese medicine combination has low cost and basically has no toxic and side effect.