48 results about "Hyposomnia" patented technology

The invention belongs to the technical field of probiotics, and particularly relates to lactobacillus reuteri ShuiMian with a sleep aiding effect and application of the lactobacillus reuteri ShuiMian. A new ShuiMian strain is separated from feces of a healthy infant in Guangzhou city, Guangdong province, PTZ is adopted to construct a zebra fish insomnia model, and research finds that the strain can inhibit eye movement frequency, inhibit brain discharge, reduce dopamine secretion, promote GABA secretion and promote Gabra gene expression, and the zebra fish insomnia model can be used for treating insomnia. The effect of promoting sleep is achieved. Therefore, the strain has a unique sleep-promoting mechanism, can assist in developing novel sleep-promoting medicines in the field of medicines, and provides a safer and more effective treatment scheme for insomnia patients. In the health care industry, a nutritional supplement can be prepared, the mass sleep quality is improved, and the development of sleep health related industries is promoted.

The invention discloses a multi-modal traditional Chinese medicine insomnia differentiation method based on multi-task deep learning, which comprises the following steps: S1, collecting tongue images and clinical text symptoms of an insomnia patient, and respectively constructing a data set I and a data set II; s2, based on the data set I and the data set II, constructing and training a multi-mode traditional Chinese medicine insomnia differentiation model; and S3, inputting the standardized tongue picture image and the structured symptom vector of the patient into the multi-mode traditional Chinese medicine insomnia dialectical model to obtain a nine-classification result matched with the traditional Chinese medicine insomnia type. According to the method, tongue body segmentation, cross-modal representation construction, quality perception fusion and multi-task prediction can be automatically completed in actual deployment, and probability distribution of nine types of symptoms and a final conclusion are output on a symptom task.

The invention relates to the field of medical treatment, and discloses a method for treating chronic insomnia by percutaneous magnetic stimulation of stellate ganglion block, which comprises the following steps: preprocessing: determining the initial position of stellate ganglion, tissue initial parameters and initial stimulation parameters through multi-modal image positioning and initialization to obtain reference data; dynamic sensing: collecting neck tissue displacement data, temperature field data and electromyographic signals in real time, and calculating spatial position variation of stellate ganglions and time-varying parameters of tissue electromagnetic characteristics; and modeling optimization: constructing a time-varying electromagnetic field distribution model based on the reference data, the spatial position variable quantity and the time-varying parameters. The method comprises the following steps: acquiring neck tissue displacement, a temperature field and an electromyographic signal in real time through reference data, capturing a stellate ganglion space position change and tissue electromagnetic property time-varying rule, constructing a time-varying electromagnetic field distribution model, and solving target stimulation parameters adaptive to a real-time tissue state through an optimal control algorithm.

The invention relates to the field of animal model construction, in particular to a construction method and application of an insomnia zebrafish model. According to the method, a model is constructed by adopting a combined induction mode of continuous white light illumination and superposition of blue light irradiation and pentyltetrazole treatment in the period, so that rapid induction of the insomnia phenotype of the zebra fish is realized. According to the method, environment and chemical factor synergistic induction is combined, and the insomnia degree is represented through multi-dimensional indexes. The zebrafish insomnia model is successfully and stably established, and the zebrafish insomnia model can be used for screening medicines or foods for improving insomnia caused by synergistic effects of environment and chemical factors, and has the advantages of short period, comprehensive phenotype and high reproducibility.

The invention discloses a device for assisting in relieving depression and insomnia of teenagers through traditional Chinese medicine acupoint application, the device comprises a flexible application module, an intelligent control system and a wearable monitoring system, the intelligent control system comprises a slow-release adjusting module, a Bluetooth module and a timing setting module, the slow-release adjusting module is used for controlling a micro-fluidic chip to release medicine, and the Bluetooth module is used for controlling the micro-fluidic chip to release medicine; the Bluetooth module is used for interconnection control with a user mobile phone APP, the timing setting module controls the micro-fluidic chips at different positions to release drugs in different time periods based on the user mobile phone APP, and the wearable monitoring system is composed of a wearable bracelet and a sensor; by designing the flexible application module which intelligently controls the effect of applying to the specific acupuncture points of the human body, the medicine application time and dosage can be automatically controlled, the transdermal efficiency of traditional Chinese medicine ingredients is improved through the physical infiltration promotion technology in cooperation with the microneedle array, and meanwhile the skin sensitivity of teenagers is prevented from being damaged by adopting a low-sensitization adhesive; and the device can realize intelligent adjustment of medicine application, and realizes personalized assistance of slow depression and insomnia symptoms.

The invention discloses a traditional Chinese medicine composition for treating anxiety insomnia. The traditional Chinese medicine composition is prepared from, by weight, 3-5 parts of rhizoma coptidis, 3-6 parts of cortex cinnamomi, 5-8 parts of fructus aurantii immaturus, 5-10 parts of radix curcumae, 5-8 parts of radix polygalae, 5-10 parts of fructus schizandrae, 5-8 parts of rhizoma chuanxiong and 1-3 parts of borneol. The traditional Chinese medicine composition can be used for preparing an external preparation navel patch, and the navel patch can be absorbed through the Shenque acupoint to play a whole regulation role. The navel patch disclosed by the invention has a remarkable curative effect on anxiety emotion caused by heart-kidney disharmony and qi stagnation and secondary anxiety insomnia symptoms such as difficulty in falling asleep, vexation, insomnia, dreaminess and easy awakening, is safe and convenient to use, provides a new solution for an external treatment method of anxiety insomnia, and has relatively high application and popularization values.

The invention belongs to the technical field of traditional Chinese medicine individuation, and provides a synergistic effect method of a traditional Chinese medicine dosage gradient scheme in insomnia treatment based on prescription dosage-efficiency science, which comprises the following steps: performing traditional Chinese medicine syndrome differentiation and typing on patients, and matching corresponding basic prescriptions according to syndromes; collecting individual characteristic parameters of a patient, and calculating an initial dose of traditional Chinese medicine according to the individual characteristic parameters; in the treatment cycle, the insomnia severity index and the Pittsburgh sleep quality index are adopted for curative effect evaluation, safety monitoring is conducted in combination with blood routine examination and liver and kidney function detection, and an evaluation result is obtained; according to an evaluation result, combining pharmacokinetic parameters, dynamically adjusting the dosage of the traditional Chinese medicine, and forming a dosage gradient scheme; synchronizing real-time lifestyle intervention and psychotherapy; through deep combination of the traditional Chinese medicine dialectical theory and modern pharmacokinetics, digital modeling and dynamic regulation and control are carried out on the dose-effect relationship of the traditional Chinese medicine, and the accuracy, safety and long-term curative effect of the traditional Chinese medicine for treating insomnia are ensured.

The invention discloses an anhypnia traditional Chinese medicine five-tone music generation method and system based on an adversarial neural network, and a medium, and the method comprises the steps: receiving traditional Chinese medicine syndrome type information corresponding to anhypnia input by a user, mapping a traditional Chinese medicine music prescription knowledge base based on preset elements, and generating a corresponding music direction vector; inputting the music orientation vector as a condition vector into an adversarial neural network, wherein the adversarial neural network outputs a music matrix corresponding to the music orientation vector; and rendering the music matrix, and outputting the traditional Chinese medicine five-tone treatment music. Differentiated customization is realized according to different syndrome type information, so that traditional Chinese medicine five-tone treatment music with higher pertinence and more stable effect is provided for insomnia patients.

A sublingual phentermine spray composition for daytime use comprises phentermine in a pharmaceutically-acceptable carrier and a sublingual phentermine spray composition for nighttime use comprises phentermine and a sleep aid in a pharmaceutically-acceptable carrier. Sublingual administration of sublingual phentermine spray compositions in accordance with the present disclosure provides an alternative to oral administration, avoiding such side effects as daytime drowsiness and intestinal disturbances. Nighttime use compositions comprising a sleep aid such as melatonin help manage the usual insomnia experienced when using phentermine. These compositions find use in suppressing appetite, for losing weight, and for maintaining a desired personal appearance.

The invention discloses a method and device for predicting the curative effect of depression with insomnia and a storage medium, and the method comprises the steps: finding a core medication strategy through the drug proportion, association strength and drug compliance, and constructing a model for predicting the curative effect of a core treatment scheme on a patient with depression with insomnia in a real diagnosis and treatment environment; and high-quality evidence is provided for personalized treatment of patients with depression. The method comprises the following steps: acquiring a medical record data set of a patient, and performing dimensionality reduction fitting on medical record data in the medical record data set to obtain a low-dimensional treatment scheme set; after calculating the similarity of the low-dimensional treatment schemes, dividing the low-dimensional treatment schemes into a plurality of groups of treatment schemes according to preset conditions; multiple groups of treatment schemes are verified through prospective follow-up visit, the relevance between medication modes of different follow-up visit points and insomnia symptoms or sleep quality is analyzed, and a core treatment scheme set is obtained; constructing a curative effect prediction model according to the core treatment scheme set and the time for controlling the illness state of the patient; and inputting medical record data of a to-be-detected patient to the curative effect prediction model to obtain a recommended treatment scheme.

The invention discloses a wild jujube cake and a preparation method thereof, relates to the technical field of homology of medicine and food, and adopts the technical scheme that the wild jujube cake is prepared from 3 parts of fried spina date seeds, 3 parts of wine steamed mulberries, 1 part of salt steamed black beans, 1 part of nine-steamed nine-sun-dried black sesames and 4 parts of refined honey. The traditional Chinese medicine can tonify the liver and the kidney, is used for treating insomnia, alopecia and leukotrichia caused by deficiency of liver blood, and particularly has a relatively obvious effect on senile insomnia and climacteric insomnia.

The invention discloses a deuterated amide compound and a preparation method and application thereof, and belongs to the technical field of medicines, deuterated amides shown in the formula I or pharmaceutically acceptable salts thereof have orexin receptor antagonism, and can be used for preparing medicines for treating sleep disorders such as insomnia. Compared with the commercially available drugs, the deuterated amide compound provided by the invention has better pharmacokinetic characteristics. And more choices are provided for clinical treatment of sleep disorder diseases. # imgabs0 #

The present application provides a composition comprising probiotics and its use for treating insomnia. Further, the present application also provides a dual orexin receptor antagonist polypeptide O-59 polypeptide, which can inhibit the over-activation of the orexin system by antagonizing the orexin 1 receptor (OX1R) and the orexin 2 receptor (OX2R), thereby improving sleep. After the polypeptide is combined with the probiotic composition, the insomnia symptoms of the insomnia mice can be significantly improved, and the application prospect is good.

Pharmaceutical compositions comprising ebastine and alprazolam are disclosed. Methods of using the pharmaceutical compositions for treating patients suffering from insomnia are also disclosed.

The invention discloses a tongue exercise and respiration collaborative conditioning method for improving refractory insomnia, and relates to the field of human health conditioning and sleep medicines.The method comprises the steps that tongue exercise exercise of a preset duration is executed in the period before sleep every day, abdominal or inverse abdominal respiration regulation is conducted in a synchronous and matched mode, and therefore tongue muscle groups are activated. In the morning or before afternoon every day, a skin needle therapy (oblique puncturing for 0.5 mm) and a bloodletting therapy are performed on specific acupuncture points (such as Yingwei points) in the oral cavity so as to activate and disperse blood stasis and increase qi and blood flow. Through the synergistic effect of lingual exercise, breathing conditioning and skin needle / bloodletting therapy, the blood supply state of the brain and the heart is improved, so that the intractable insomnia symptom caused by neurasthenia, physical weakness, cardio-cerebral ischemia and the like is relieved from the source. The method emphasizes multi-dimensional collaborative conditioning, can adapt to different crowds, can be dynamically adjusted through effect evaluation, and aims to realize a physical insomnia intervention mode without drug dependence.

The invention discloses a traditional Chinese medicine heart nourishing and nerve soothing formula for treating insomnia. The formula is composed of spina date seed, mulberry, dendrobium, trichosanthes peel, cassia seed, dark plum, poria with hostwood and green plum blossom. The heart-nourishing and mind-tranquilizing formula is mainly used for nourishing the heart, tranquilizing the mind, nourishing yin, clearing heat, soothing the liver and relieving depression, and spina date seeds and poria with hostwood in the formula are used as monarch materials to nourish heart yin, tranquilize the mind, stabilize the mind and Mulberry, dendrobium and dark plum are used as ministerial drugs to nourish yin, promote salivation, clear deficiency heat and improve dysphoria, night sweat and dry mouth caused by fire excess from yin deficiency. The semen cassiae has the effects of clearing liver fire and relaxing bowel, and the semen cassiae and the semen cassiae can assist in clearing away the heart-fire and reducing phlegm; the green plum blossom can soothe liver depression without hurting yin, and is capable of soothing liver, harmonizing stomach and regulating qi. The prescription is used for overall conditioning of complex pathogenesis (yin deficiency, liver depression and phlegm heat) of insomnia, and is especially suitable for people with insomnia caused by high pressure, unsmooth emotion and staying up late at present. Compatible medication has local characteristics of new-safety medicine, is particularly beneficial to improvement of insomnia symptoms and the like, and is definite in curative effect and free of toxic and side effects.

The present invention relates to a method of treating insomnia in a subject in need thereof, comprising administering to the subject a therapeutically effective amount of certain carbamate compounds.

1. The name of the design product: transcranial micro-current stimulation instrument. 2. The use of the design product: for assisting to improve insomnia symptoms. 3. The design points of the design product: in shape. 4. The picture or photo that best indicates the design points: perspective view 1.

The application discloses an oral preparation capable of improving 5-HT level in the brain and application thereof in improving insomnia, and belongs to the field of food science. The oral preparation uses starch and beta-cyclodextrin as nanoparticle carriers to wrap 5-HTP, can effectively control the release rate of 5-HTP, makes it slowly release in the gastrointestinal tract, and improves the defect that the half-life of 5-HTP is short. The preparation can significantly improve the content of 5-HT in the brain, and improve the metabolic kinetic characteristics of 5-HT, thereby effectively improving the insomnia symptoms. Experimental data shows that, compared with the traditional 5-HTP, the slow-release preparation has better bioavailability and longer brain drug efficacy duration. The innovative preparation not only has significant advantages in technology, but also opens up a new, safe and effective way for the treatment of 5-HT related nervous system diseases, and has important application value and research significance.

The invention provides a composition for preventing or improving sleep disorders and a preparation method and application thereof, and belongs to the technical field of medicine and health care. The composition is prepared from the following raw material components in parts by weight: 3 to 36 parts of radix salviae miltiorrhizae, 2 to 30 parts of radix notoginseng, 3 to 36 parts of semen ziziphi spinosae and 1 to 30 parts of fructus phyllanthi. Tibetan red sage root, Tibetan pseudo-ginseng, spina date seed and emblic leafflower fruit are compatible and can synergistically play a synergistic role in promoting blood circulation to remove blood stasis, nourishing blood and tranquilizing, dispersing blood stasis and stopping bleeding, diminishing swelling and relieving pain, nourishing heart and benefiting liver, tranquilizing and arresting sweating and the like, and the blood stasis type insomnia symptom can be effectively improved.

The present application belongs to the field of traditional Chinese medicine, and relates to medical uses of Sishen pills or extracts thereof. Specifically, any one selected from items (1)-(3) below in the preparation of a drug for sedative-hypnotic, treatment or prevention of insomnia, anti-anxiety, or sleep regulation: (1) a pharmaceutical composition comprising Myristicae Semen, Fructus Psoraleae, Schisandra chinensis, Evodia rutaecarpa, Fructus Jujubae, and Zingiber officinale; (2) an extract which is a water extract and / or an ethanol extract of the pharmaceutical composition in item (1); and (3) a pharmaceutical preparation comprising the extract in item (2) and one or more pharmaceutically acceptable excipients. The pharmaceutical composition, extract or pharmaceutical preparation described in the present application has good sedative-hypnotic, prophylactic or therapeutic effects on insomnia, or sleep regulation.

The present invention belongs to the field of pharmaceutical technology and relates to a tablet for treating insomnia and its preparation method. Disclosed are YZG-331 tablets, a drug for treating insomnia, as represented by Formula I, and its preparation method. Specifically disclosed are the formulation composition and preparation process of YZG-331 tablets. #imgabs0#

The application provides an insomnia psychological behavior treatment cabin, which comprises a cabin body, a massage assembly, a driving assembly, a breathing control assembly and an airflow control assembly. A user lies flat on the cabin body, and a belt is fastened on the abdomen. A motor is started, and the user adjusts the breathing rhythm according to the pressure on the abdomen. The working principle of the whole treatment cabin is that when the belt loosens the abdomen of the user, the airflow control assembly blows air to the face of the user; when the belt tightens the abdomen of the user, the airflow control assembly stops blowing air to the face of the user. The coordination is realized through the synchronous rotation of the first rotating shaft and the second rotating shaft. Due to the design of the special-shaped sliding groove and the arrangement of the pushing rod, the breathing control and the airflow control can form opposite working states, which help the user to establish a correct abdominal breathing mode, and cooperate with the massage function and the action of the sleep aid to effectively improve the insomnia symptoms.

1. The name of this design product: Low-frequency stimulation headache and insomnia therapeutic device. 2. Purpose of this product design: This product is used to improve or relieve insomnia symptoms. 3. The key point of the design of this product lies in the shape of the product. 4. The picture or photo that best illustrates the design points: three-dimensional picture. 5. The design for which protection is sought includes color.

The invention belongs to the technical field of traditional Chinese medicines, and provides a traditional Chinese medicine composition for treating insomnia and a preparation method and application thereof. The traditional Chinese medicine composition comprises the following components in parts by weight: radix bupleuri, rhizoma pinelliae preparata, red ginseng, scutellaria baicalensis, dragon bone, oyster, poria with hostwood, polygala tenuifolia, tuber fleeceflower stem, amethyst and honey-fried licorice root. According to the treatment principle of quieting heart and benefiting gallbladder, radix bupleuri, scutellaria baicalensis, pinellia ternate, red ginseng, dragon bone, oyster, poria with hostwood and amethyst, polygala tenuifolia, tuber fleeceflower stem and honey-fried licorice root are used for harmonizing heart and benefiting gallbladder. The traditional Chinese medicine composition disclosed by the invention is remarkable in effect of improving insomnia symptoms, exact in curative effect, free of toxic and side effects and remarkable in market prospect.

The disclosure provides methods of delaying relapse, or maintaining stable response or stable remission, in patients with major depressive disorder with insomnia symptoms (MDDIS).

This invention relates to the fields of digital healthcare and sleep health management technology, and particularly to an insomnia screening and dynamic management system and method. The system includes modules for data acquisition, verification, feature calculation, and strategy generation. The data acquisition module simultaneously acquires subjective, objective, and environmental data streams; the data verification module calculates confidence levels using the coupling characteristics of temperature and heart rate, identifies non-physiological interferences to clean the data; the feature calculation module calculates a sleep perception deviation index to quantify subjective and objective differences, constructs a cumulative sleep pressure model, and integrates body temperature and heart rate characteristics to locate individual biological time; the strategy generation module distinguishes between contradictory and physiological insomnia based on the deviation index to select intervention paths, and remaps the treatment recommendation time to an execution time adapted to the individual's circadian rhythm. This invention utilizes signal coupling verification to ensure data quality, accurately classifies insomnia through the perception deviation index, and achieves dynamic intervention adapted to the individual's circadian rhythm based on biological time mapping.

The invention provides a traditional Chinese medicine composition product for treating insomnia symptoms, and relates to the technical field of traditional Chinese medicines, and the traditional Chinese medicine composition product comprises cortex phellodendri, crude dragon bone, raw oyster, raw malt, rhizoma nardostachyos, patrinia and liquorice. The traditional Chinese medicine formula comprises the following components in parts by weight: 9-12 g of cortex phellodendri, 18-20 g of raw dragon bone, 18-20 g of raw oyster shell, 9-12 g of raw malt, 20-30 g of rhizoma nardostachyos, 13-15 g of herba patriniae and 3-5 g of liquorice. The traditional Chinese medicine composition has the advantages that multiple components in a prescription can regulate synthesis, release and uptake of neurotransmitters such as 5-hydroxytryptamine, gamma-aminobutyric acid and dopamine of the brain and maintain neurotransmitter balance, so that sleep is improved; the prescription can regulate the function of an HPA axis, reduce the secretion level of cortisol and other stress hormones in a stress state, relieve the stress response of an organism, relieve anxiety and nervous mood and promote sleep; part of the components in the formula have anti-inflammatory and antioxidant activity, can relieve brain nerve inflammatory response, reduce damage of free radicals to nerve cells, protect nerve cell functions, and provide a good intra-nerve environment for sleep improvement.

The invention relates to a traditional Chinese medicine composition for clearing away heat and toxic materials and cooling blood, a preparation method and application and belongs to the field of traditional Chinese medicine. The traditional Chinese medicine composition for clearing away heat and toxic materials and cooling blood comprises coptis chinensis, pulsatilla chinensis, cortex fraxini, Chinese yam, semen coicis, liquorice, codonopsis pilosula, poria cocos, plantain herb and the like, can be used for treating snake wounds, and effectively relieves snake venom symptoms and promotes body recovery through multiple effects of clearing away heat and toxic materials, relieving swelling and pain and strengthening body resistance to eliminate pathogenic factors; the traditional Chinese medicine can also be used for relieving insomnia and skin allergy symptoms, and has very good curative effects.

The invention discloses a traditional Chinese medicine composition for treating insomnia and a preparation method thereof, and relates to the field of traditional Chinese medicine compositions. The invention aims to solve the problems of unscientific compatibility, unstable curative effect, inconvenience in use and the like in the existing traditional Chinese medicine composition for treating insomnia. The traditional Chinese medicine composition comprises the following components in parts by weight: 18-25 parts of cortex albiziae, 15-25 parts of fried spina date seed, 10-15 parts of rhizoma nardostachyos, 15-30 parts of vine of multiflower knotweed, 8-10 parts of ginger processed pinellia, 15-30 parts of poria cocos, 10-20 parts of schisandra chinensis, 6-10 parts of rose and 15-30 parts of calcined nacre mother of pearl. Through scientific compatibility and synergistic effect of the components, the traditional Chinese medicine composition can significantly improve insomnia symptoms, regulate body functions and improve overall sleep quality, and is small in side effect and suitable for long-term administration.