28 results about "Hyposomnia" patented technology

The invention discloses a multi-modal traditional Chinese medicine insomnia differentiation method based on multi-task deep learning, which comprises the following steps: S1, collecting tongue images and clinical text symptoms of an insomnia patient, and respectively constructing a data set I and a data set II; s2, based on the data set I and the data set II, constructing and training a multi-mode traditional Chinese medicine insomnia differentiation model; and S3, inputting the standardized tongue picture image and the structured symptom vector of the patient into the multi-mode traditional Chinese medicine insomnia dialectical model to obtain a nine-classification result matched with the traditional Chinese medicine insomnia type. According to the method, tongue body segmentation, cross-modal representation construction, quality perception fusion and multi-task prediction can be automatically completed in actual deployment, and probability distribution of nine types of symptoms and a final conclusion are output on a symptom task.

The invention relates to the field of medical treatment, and discloses a method for treating chronic insomnia by percutaneous magnetic stimulation of stellate ganglion block, which comprises the following steps: preprocessing: determining the initial position of stellate ganglion, tissue initial parameters and initial stimulation parameters through multi-modal image positioning and initialization to obtain reference data; dynamic sensing: collecting neck tissue displacement data, temperature field data and electromyographic signals in real time, and calculating spatial position variation of stellate ganglions and time-varying parameters of tissue electromagnetic characteristics; and modeling optimization: constructing a time-varying electromagnetic field distribution model based on the reference data, the spatial position variable quantity and the time-varying parameters. The method comprises the following steps: acquiring neck tissue displacement, a temperature field and an electromyographic signal in real time through reference data, capturing a stellate ganglion space position change and tissue electromagnetic property time-varying rule, constructing a time-varying electromagnetic field distribution model, and solving target stimulation parameters adaptive to a real-time tissue state through an optimal control algorithm.

The invention discloses a traditional Chinese medicine composition for treating anxiety insomnia. The traditional Chinese medicine composition is prepared from, by weight, 3-5 parts of rhizoma coptidis, 3-6 parts of cortex cinnamomi, 5-8 parts of fructus aurantii immaturus, 5-10 parts of radix curcumae, 5-8 parts of radix polygalae, 5-10 parts of fructus schizandrae, 5-8 parts of rhizoma chuanxiong and 1-3 parts of borneol. The traditional Chinese medicine composition can be used for preparing an external preparation navel patch, and the navel patch can be absorbed through the Shenque acupoint to play a whole regulation role. The navel patch disclosed by the invention has a remarkable curative effect on anxiety emotion caused by heart-kidney disharmony and qi stagnation and secondary anxiety insomnia symptoms such as difficulty in falling asleep, vexation, insomnia, dreaminess and easy awakening, is safe and convenient to use, provides a new solution for an external treatment method of anxiety insomnia, and has relatively high application and popularization values.

The invention discloses an anhypnia traditional Chinese medicine five-tone music generation method and system based on an adversarial neural network, and a medium, and the method comprises the steps: receiving traditional Chinese medicine syndrome type information corresponding to anhypnia input by a user, mapping a traditional Chinese medicine music prescription knowledge base based on preset elements, and generating a corresponding music direction vector; inputting the music orientation vector as a condition vector into an adversarial neural network, wherein the adversarial neural network outputs a music matrix corresponding to the music orientation vector; and rendering the music matrix, and outputting the traditional Chinese medicine five-tone treatment music. Differentiated customization is realized according to different syndrome type information, so that traditional Chinese medicine five-tone treatment music with higher pertinence and more stable effect is provided for insomnia patients.

The invention discloses a method and device for predicting the curative effect of depression with insomnia and a storage medium, and the method comprises the steps: finding a core medication strategy through the drug proportion, association strength and drug compliance, and constructing a model for predicting the curative effect of a core treatment scheme on a patient with depression with insomnia in a real diagnosis and treatment environment; and high-quality evidence is provided for personalized treatment of patients with depression. The method comprises the following steps: acquiring a medical record data set of a patient, and performing dimensionality reduction fitting on medical record data in the medical record data set to obtain a low-dimensional treatment scheme set; after calculating the similarity of the low-dimensional treatment schemes, dividing the low-dimensional treatment schemes into a plurality of groups of treatment schemes according to preset conditions; multiple groups of treatment schemes are verified through prospective follow-up visit, the relevance between medication modes of different follow-up visit points and insomnia symptoms or sleep quality is analyzed, and a core treatment scheme set is obtained; constructing a curative effect prediction model according to the core treatment scheme set and the time for controlling the illness state of the patient; and inputting medical record data of a to-be-detected patient to the curative effect prediction model to obtain a recommended treatment scheme.

The present application provides a composition comprising probiotics and its use for treating insomnia. Further, the present application also provides a dual orexin receptor antagonist polypeptide O-59 polypeptide, which can inhibit the over-activation of the orexin system by antagonizing the orexin 1 receptor (OX1R) and the orexin 2 receptor (OX2R), thereby improving sleep. After the polypeptide is combined with the probiotic composition, the insomnia symptoms of the insomnia mice can be significantly improved, and the application prospect is good.

Pharmaceutical compositions comprising ebastine and alprazolam are disclosed. Methods of using the pharmaceutical compositions for treating patients suffering from insomnia are also disclosed.

The invention discloses a tongue exercise and respiration collaborative conditioning method for improving refractory insomnia, and relates to the field of human health conditioning and sleep medicines.The method comprises the steps that tongue exercise exercise of a preset duration is executed in the period before sleep every day, abdominal or inverse abdominal respiration regulation is conducted in a synchronous and matched mode, and therefore tongue muscle groups are activated. In the morning or before afternoon every day, a skin needle therapy (oblique puncturing for 0.5 mm) and a bloodletting therapy are performed on specific acupuncture points (such as Yingwei points) in the oral cavity so as to activate and disperse blood stasis and increase qi and blood flow. Through the synergistic effect of lingual exercise, breathing conditioning and skin needle / bloodletting therapy, the blood supply state of the brain and the heart is improved, so that the intractable insomnia symptom caused by neurasthenia, physical weakness, cardio-cerebral ischemia and the like is relieved from the source. The method emphasizes multi-dimensional collaborative conditioning, can adapt to different crowds, can be dynamically adjusted through effect evaluation, and aims to realize a physical insomnia intervention mode without drug dependence.

The present invention relates to a method of treating insomnia in a subject in need thereof, comprising administering to the subject a therapeutically effective amount of certain carbamate compounds.

1. The name of the design product: transcranial micro-current stimulation instrument. 2. The use of the design product: for assisting to improve insomnia symptoms. 3. The design points of the design product: in shape. 4. The picture or photo that best indicates the design points: perspective view 1.

The application discloses an oral preparation capable of improving 5-HT level in the brain and application thereof in improving insomnia, and belongs to the field of food science. The oral preparation uses starch and beta-cyclodextrin as nanoparticle carriers to wrap 5-HTP, can effectively control the release rate of 5-HTP, makes it slowly release in the gastrointestinal tract, and improves the defect that the half-life of 5-HTP is short. The preparation can significantly improve the content of 5-HT in the brain, and improve the metabolic kinetic characteristics of 5-HT, thereby effectively improving the insomnia symptoms. Experimental data shows that, compared with the traditional 5-HTP, the slow-release preparation has better bioavailability and longer brain drug efficacy duration. The innovative preparation not only has significant advantages in technology, but also opens up a new, safe and effective way for the treatment of 5-HT related nervous system diseases, and has important application value and research significance.

The present application belongs to the field of traditional Chinese medicine, and relates to medical uses of Sishen pills or extracts thereof. Specifically, any one selected from items (1)-(3) below in the preparation of a drug for sedative-hypnotic, treatment or prevention of insomnia, anti-anxiety, or sleep regulation: (1) a pharmaceutical composition comprising Myristicae Semen, Fructus Psoraleae, Schisandra chinensis, Evodia rutaecarpa, Fructus Jujubae, and Zingiber officinale; (2) an extract which is a water extract and / or an ethanol extract of the pharmaceutical composition in item (1); and (3) a pharmaceutical preparation comprising the extract in item (2) and one or more pharmaceutically acceptable excipients. The pharmaceutical composition, extract or pharmaceutical preparation described in the present application has good sedative-hypnotic, prophylactic or therapeutic effects on insomnia, or sleep regulation.

The application provides an insomnia psychological behavior treatment cabin, which comprises a cabin body, a massage assembly, a driving assembly, a breathing control assembly and an airflow control assembly. A user lies flat on the cabin body, and a belt is fastened on the abdomen. A motor is started, and the user adjusts the breathing rhythm according to the pressure on the abdomen. The working principle of the whole treatment cabin is that when the belt loosens the abdomen of the user, the airflow control assembly blows air to the face of the user; when the belt tightens the abdomen of the user, the airflow control assembly stops blowing air to the face of the user. The coordination is realized through the synchronous rotation of the first rotating shaft and the second rotating shaft. Due to the design of the special-shaped sliding groove and the arrangement of the pushing rod, the breathing control and the airflow control can form opposite working states, which help the user to establish a correct abdominal breathing mode, and cooperate with the massage function and the action of the sleep aid to effectively improve the insomnia symptoms.

The invention belongs to the technical field of traditional Chinese medicines, and provides a traditional Chinese medicine composition for treating insomnia and a preparation method and application thereof. The traditional Chinese medicine composition comprises the following components in parts by weight: radix bupleuri, rhizoma pinelliae preparata, red ginseng, scutellaria baicalensis, dragon bone, oyster, poria with hostwood, polygala tenuifolia, tuber fleeceflower stem, amethyst and honey-fried licorice root. According to the treatment principle of quieting heart and benefiting gallbladder, radix bupleuri, scutellaria baicalensis, pinellia ternate, red ginseng, dragon bone, oyster, poria with hostwood and amethyst, polygala tenuifolia, tuber fleeceflower stem and honey-fried licorice root are used for harmonizing heart and benefiting gallbladder. The traditional Chinese medicine composition disclosed by the invention is remarkable in effect of improving insomnia symptoms, exact in curative effect, free of toxic and side effects and remarkable in market prospect.

The disclosure provides methods of delaying relapse, or maintaining stable response or stable remission, in patients with major depressive disorder with insomnia symptoms (MDDIS).

This invention relates to the fields of digital healthcare and sleep health management technology, and particularly to an insomnia screening and dynamic management system and method. The system includes modules for data acquisition, verification, feature calculation, and strategy generation. The data acquisition module simultaneously acquires subjective, objective, and environmental data streams; the data verification module calculates confidence levels using the coupling characteristics of temperature and heart rate, identifies non-physiological interferences to clean the data; the feature calculation module calculates a sleep perception deviation index to quantify subjective and objective differences, constructs a cumulative sleep pressure model, and integrates body temperature and heart rate characteristics to locate individual biological time; the strategy generation module distinguishes between contradictory and physiological insomnia based on the deviation index to select intervention paths, and remaps the treatment recommendation time to an execution time adapted to the individual's circadian rhythm. This invention utilizes signal coupling verification to ensure data quality, accurately classifies insomnia through the perception deviation index, and achieves dynamic intervention adapted to the individual's circadian rhythm based on biological time mapping.

The invention discloses a traditional Chinese medicine composition for treating insomnia and a preparation method thereof, and relates to the field of traditional Chinese medicine compositions. The invention aims to solve the problems of unscientific compatibility, unstable curative effect, inconvenience in use and the like in the existing traditional Chinese medicine composition for treating insomnia. The traditional Chinese medicine composition comprises the following components in parts by weight: 18-25 parts of cortex albiziae, 15-25 parts of fried spina date seed, 10-15 parts of rhizoma nardostachyos, 15-30 parts of vine of multiflower knotweed, 8-10 parts of ginger processed pinellia, 15-30 parts of poria cocos, 10-20 parts of schisandra chinensis, 6-10 parts of rose and 15-30 parts of calcined nacre mother of pearl. Through scientific compatibility and synergistic effect of the components, the traditional Chinese medicine composition can significantly improve insomnia symptoms, regulate body functions and improve overall sleep quality, and is small in side effect and suitable for long-term administration.

This invention discloses a method for preparing a traditional Chinese medicine compound essential oil preparation to improve sleep, belonging to the field of health product processing and preparation technology. The method selects seven medicinal and edible herbs, including jujube seed, polygala root, and sandalwood, and accurately combines them in a compound system to achieve both "calming the mind" and "nourishing the blood." It can quickly relieve insomnia symptoms such as frequent dreams, easy awakening, palpitations, and forgetfulness, and can also regulate the constitution of deficiency of both heart and spleen from the root. At the same time, it adopts a combination of supercritical CO2 extraction and molecular distillation purification process. Compared with steam distillation, supercritical CO2 extraction can retain heat-sensitive effective components such as jujube seed saponins and polygala root volatile oil to the maximum extent and avoid loss of effective components. Molecular distillation purification process can effectively remove impurities such as polysaccharides, proteins, and waxes from crude essential oils, greatly improving the transparency, stability, and user experience of essential oils, while reducing the risk of skin irritation.

The application discloses a traditional Chinese medicine composition for improving heart-kidney incoordination type insomnia and a preparation method and application of a capsule of the traditional Chinese medicine composition. The traditional Chinese medicine composition is composed of the following raw medicinal materials: eucommia ulmoides, acanthopanax bark, spina date, albizia flower, radix bupleuri, gastrodia elata, polygala, and ligusticum chuanxiong. The application further discloses a preparation method of a capsule preparation of the traditional Chinese medicine composition for improving heart-kidney incoordination type insomnia. The traditional Chinese medicine composition provided by the application is mainly composed of traditional Chinese medicinal materials with the same effect on food and medicine, has the effects of tonifying liver and kidney, nourishing heart and calming mind, and soothing liver and relieving depression, and can effectively improve heart-kidney incoordination type insomnia.

The invention relates to the technical field of animal evaluation models, and discloses an insomnia zebrafish model and a modeling method thereof.The insomnia zebrafish model is prepared from zebrafish and a culture solution, the culture solution comprises one of water and dilution water, the culture solution is vortex, the vortex flow rate is 0.07-0.1 m / s, and the vortex flow rate is 0.07-0.1 m / s; comprising the following steps: adding a culture solution into a culture dish to form eddy current, and then putting zebra fish into the culture dish for modeling culture; according to the method, vortex stimulation is adopted for modeling the insomnia zebra fish, the vortex stimulation can prevent water flow from damaging the zebra fish, the interference effect of pain factors on the insomnia zebra fish model can be avoided, and the non-painful insomnia can be accurately evaluated.

The invention discloses a Tujia ear phyllostachys pubescens scraping therapy clinical curative effect evaluation system and method, and belongs to the technical field of traditional Chinese medicine clinical curative effect evaluation. The hierarchical data acquisition system is used for integrating a basic version component and a professional version component and supporting scene-based data acquisition; the Tujia medical feature extraction module is used for analyzing eruptive disease features through a lightweight CNN model and calculating liver depression and spleen deficiency syndrome integrals by combining primary and secondary disease weights; the cloud-edge collaborative architecture is used for calculating a scraping force standard deviation sigma in real time and dynamically triggering a cloud high-precision analysis and PSQI dynamic prediction model; according to the dynamic synergistic effect model, a synergistic coefficient K is calculated in a segmented mode based on the scraping force standard deviation sigma, and quantitative combined therapy synergy is achieved; and the visual interaction interface is used for generating a three-dimensional ear curative effect atlas and outputting parameter optimization suggestions. Through multi-modal data fusion and ethnic medicine feature quantification, objective and dynamic evaluation of the curative effect of chronic insomnia is realized, and the standardization level and generalizability of the scraping therapy are remarkably improved.

The invention belongs to the technical field of medicines, and particularly relates to a traditional Chinese medicine cocculus orbiculatus decoction compound preparation for treating advanced non-small cell lung cancer. The compound preparation is granular and comprises the following components: radix stephaniae tetrandrae, gypsum, cassia twig and ginseng. The traditional Chinese medicine composition comprises the following components by weight: 10-15 g of radix stephaniae tetrandrae, 10-15 g of gypsum, 3-12 g of cassia twig and 12-15 g of ginseng. In clinical experiments, the experimental group is treated by combining the cocculus orbiculatus decoction with the conventional scheme, and the control group is treated by combining the cocculus orbiculatus decoction simulation agent group with the conventional scheme. And comparing the two groups of patients with no progression lifetime (PFS), physical strength status (PS), quality of life and adverse reaction. The results show that the cocculus orbiculatus decoction preparation can effectively prolong the PFS of a patient suffering from the advanced non-small cell lung cancer, better improve the PS score and life quality of the patient, has a certain improvement effect on weakness, shortness of breath and insomnia symptoms with high occurrence rate of the advanced non-small cell lung cancer, and also has good safety.

The present application relates to the technical field of traditional Chinese medicine, and particularly relates to a longan aril steamed American ginseng processed product for regulating blood sugar, a preparation method and application thereof. The longan aril steamed American ginseng processed product is prepared by taking American ginseng as a main raw material and longan aril as an auxiliary material. Experiments show that the longan aril significantly enhances the blood sugar lowering effect of American ginseng. Further, the processing parameters are comprehensively optimized, and the prepared processed product is mainly used for treating diabetes (abnormal blood sugar) and its accompanying symptoms (such as insomnia) with deficiency of both qi and yin and blood stasis, and the blood sugar regulating effect is significantly better than that of American ginseng steamed products and American ginseng processed products prepared by using other auxiliary materials (such as ginger steamed American ginseng processed product), and is suitable for treating type 2 diabetes and its accompanying symptoms (such as insomnia).

1. The name of the design product: insomnia treatment instrument. 2. The use of the design product: suitable for the auxiliary treatment of non-organic insomnia patients. 3. The design points of the design product: in shape. 4. The picture or photo that best indicates the design points: perspective drawing.

The invention discloses traditional Chinese medicine formula essential oil for improving insomnia, and relates to the technical field of traditional Chinese medicine essential oil. The traditional Chinese medicine formula essential oil can achieve the effect of improving the insomnia symptom of a patient. The traditional Chinese medicine composition specifically comprises 40-50% of a monarch drug, 20-30% of a ministerial drug, 15-20% of an adjuvant drug and 5-10% of a conductant drug, the monarch drug is spina date seed essential oil having a core tranquilizing effect, the ministerial drug is rhizoma cyperi essential oil and pericarpium citri reticulatae essential oil which have the effects of promoting qi circulation, relieving depression and promoting penetration and dispersion, the adjuvant drug is a radix ophiopogonis extract and lavender essential oil which have the effects of nourishing yin and clearing heat, and the conductant drug is licorice essential oil or sandalwood essential oil. The traditional Chinese medicine formula essential oil comprises 40% of a monarch drug, 30% of a ministerial drug, 20% of an adjuvant drug and 10% of a conductant drug. According to the invention, the traditional Chinese medicine theory of soothing nerves and helping sleep is taken as a core, the dual advantages of'transdermal absorption and aromatherapy 'of essential oil are combined, and the effect of mildly improving insomnia is achieved through the comprehensive efficacy of the spina date seed essential oil, the rhizoma cyperi essential oil, the pericarpium citri reticulatae essential oil, the lavender essential oil, the liquorice essential oil and the sandalwood essential oil.

The invention discloses an analgesic and sleep-aiding essential oil composition containing origanum vulgare flower oil as well as a preparation method and application of the analgesic and sleep-aiding essential oil composition. The invention provides an essential oil composition. The essential oil composition comprises the following components in parts by weight: 15-45 parts of origanum vulgare flower oil, 5-15 parts of lavender oil, 5-15 parts of bitter orange leaf oil, 1-10 parts of a hop extract, 1-10 parts of chamomilla recutita flower oil and 1-5 parts of jasmine flower oil. According to the compound essential oil composition, on the basis of the compatibility principle of monarch, minister, assistant and guide of traditional Chinese medicines, origanum vulgare flower oil is selected as a monarch drug, lavender oil and bitter orange leaf oil are selected as minister drugs, chamomilla recutita flower oil and a humulus lupulus extract are selected as assistants, and jasmine flower oil is matched as a guide, so that the compound essential oil capable of helping sleep, soothing the nerves, easing pain and resisting inflammation is prepared. And insomnia symptoms such as difficulty in falling asleep, dreaminess and easy awakening caused by chronic pain can be relieved. The essential oil is extracted from plants containing natural active ingredients, the essential oil and the essential oil have a synergistic effect, the curative effect can be enhanced, the ingredients are safe and effective, and toxic and side effects are avoided.

The invention relates to the technical field of traditional Chinese medicines, in particular to a traditional Chinese medicine composition for treating insomnia, a traditional Chinese medicine extract and application. The traditional Chinese medicine composition comprises the following traditional Chinese medicine raw materials: fried spina date seed, roasted polygala tenuifolia, poria with hostwood, platycladi seed, longan, dragon bone, magnetite, ginseng, angelica sinensis, astragalus membranaceus, prepared rehmannia root, parched white peony root, poria cocos, roasted rhizoma atractylodis macrocephalae, prepared schisandra chinensis, pericarpium citri reticulatae, gardenia, jujube, ginger and honey-fried licorice root. The traditional Chinese medicine composition disclosed by the invention realizes a breakthrough in the application level and breaks through the limitation cognition in the field of traditional Chinese medicines, so that the synergistic effect of sleep improvement and whole body symptom relief is realized, and the traditional Chinese medicine composition is adaptive to the clinical characteristic of insomnia patients that insomnia is dominated and multiple symptoms coexist.

This invention discloses a traditional Chinese medicine composition for improving sleep, its preparation method, and its application. The traditional Chinese medicine composition includes: *Scutellaria baicalensis*, *Ipomoea quamoclit*, *Piper kadsura*, *Plantago asiatica*, and *Aster tataricus* in a mass ratio of 0.5–2:1–3:2–6:1–3:1–3. This invention selects various traditional Chinese medicine components and explores their mixing ratios and dosages to prepare the corresponding traditional Chinese medicine composition. Studies have found that compared to single-component formulas, the traditional Chinese medicine composition of this invention, through the synergistic effect between its components, can significantly inhibit the distance of spontaneous activity in mice and increase the sedation rate, thus it can be formulated into a sedative drug. Simultaneously, when the traditional Chinese medicine composition is combined with subthreshold or suprathreshold doses of sodium pentobarbital in mice, it can effectively increase the sleep onset rate, shorten the sleep latency, and significantly prolong the sleep time. Therefore, the traditional Chinese medicine composition of this invention has the effect of improving sleep, providing experimental evidence for its drug development and utilization in the treatment of insomnia.