67 results about "Hyposomnia" patented technology

The invention belongs to the technical field of probiotics, and particularly relates to lactobacillus reuteri ShuiMian with a sleep aiding effect and application of the lactobacillus reuteri ShuiMian. A new ShuiMian strain is separated from feces of a healthy infant in Guangzhou city, Guangdong province, PTZ is adopted to construct a zebra fish insomnia model, and research finds that the strain can inhibit eye movement frequency, inhibit brain discharge, reduce dopamine secretion, promote GABA secretion and promote Gabra gene expression, and the zebra fish insomnia model can be used for treating insomnia. The effect of promoting sleep is achieved. Therefore, the strain has a unique sleep-promoting mechanism, can assist in developing novel sleep-promoting medicines in the field of medicines, and provides a safer and more effective treatment scheme for insomnia patients. In the health care industry, a nutritional supplement can be prepared, the mass sleep quality is improved, and the development of sleep health related industries is promoted.

The invention discloses a multi-modal traditional Chinese medicine insomnia differentiation method based on multi-task deep learning, which comprises the following steps: S1, collecting tongue images and clinical text symptoms of an insomnia patient, and respectively constructing a data set I and a data set II; s2, based on the data set I and the data set II, constructing and training a multi-mode traditional Chinese medicine insomnia differentiation model; and S3, inputting the standardized tongue picture image and the structured symptom vector of the patient into the multi-mode traditional Chinese medicine insomnia dialectical model to obtain a nine-classification result matched with the traditional Chinese medicine insomnia type. According to the method, tongue body segmentation, cross-modal representation construction, quality perception fusion and multi-task prediction can be automatically completed in actual deployment, and probability distribution of nine types of symptoms and a final conclusion are output on a symptom task.

The invention relates to the field of medical treatment, and discloses a method for treating chronic insomnia by percutaneous magnetic stimulation of stellate ganglion block, which comprises the following steps: preprocessing: determining the initial position of stellate ganglion, tissue initial parameters and initial stimulation parameters through multi-modal image positioning and initialization to obtain reference data; dynamic sensing: collecting neck tissue displacement data, temperature field data and electromyographic signals in real time, and calculating spatial position variation of stellate ganglions and time-varying parameters of tissue electromagnetic characteristics; and modeling optimization: constructing a time-varying electromagnetic field distribution model based on the reference data, the spatial position variable quantity and the time-varying parameters. The method comprises the following steps: acquiring neck tissue displacement, a temperature field and an electromyographic signal in real time through reference data, capturing a stellate ganglion space position change and tissue electromagnetic property time-varying rule, constructing a time-varying electromagnetic field distribution model, and solving target stimulation parameters adaptive to a real-time tissue state through an optimal control algorithm.

The invention relates to the field of insomnia treatment, in particular to a traditional Chinese medicine composition for treating insomnia caused by upper heat, lower cold and middle-jiao deficiency, which comprises the following Chinese herbal medicines: smoked plum, processed monkshood, cassia twig, ginseng, angelica sinensis, asarum, rhizoma zingiberis, pericarpium zanthoxyli, golden cypress, coptis chinensis, bitter wine, polished round-grained rice, honey, lily, tuber fleeceflower stem, hericium erinaceus, polygala tenuifolia and poria with hostwood. The pill is prepared from a traditional Chinese medicine composition of dark plum, processed monkshood, cassia twig, ginseng, angelica sinensis, asarum, rhizoma zingiberis, pericarpium zanthoxyli, golden cypress, coptis chinensis, bitter wine, polished round-grained rice, honey, lily, tuber fleeceflower stem, hericium erinaceus, polygala tenuifolia and poria with hostwood. The traditional Chinese medicine composition can comprehensively improve insomnia symptoms caused by upper heat, lower cold and middle-jiao deficiency, and is quick in effect taking, high in safety and small in side effect.

The invention discloses a pharmaceutical composition for insomnia (heart-spleen deficiency type) and hypomnesis and a preparation method of the pharmaceutical composition, and relates to the technical field of medicines.The composition is prepared from acanthopanax, astragalus membranaceus, lucid ganoderma, ginseng leaves, schisandra chinensis and gastrodia elata, the prescription mainly aims at the pathogenesis of insomnia caused by heart-spleen deficiency, the synergistic effect is achieved from multiple aspects, and the curative effect is good. The traditional Chinese medicine composition has the effect of treating insomnia caused by heart and spleen, and is a comprehensive and effective treatment scheme. Meanwhile, the effect of improving memory is also achieved. The prescription provided by the invention can be prepared into granules, oral preparations and the like. The pharmaceutical composition disclosed by the invention has a remarkable insomnia treatment effect which is superior to that of Western medicines such as eszopiclone tablets and estazolam tablets, the sleep inducing time is shortened, the sleep time of a patient with difficulty in falling asleep can be effectively shortened, meanwhile, the sleep time is optimally prolonged, the insomnia treatment effect is remarkable, and the situations of somnolence and non-awakening are avoided; the memory can also be improved. Meanwhile, no dependence is caused, and the insomnia is fundamentally treated.

The invention relates to the field of animal model construction, in particular to a construction method and application of an insomnia zebrafish model. According to the method, a model is constructed by adopting a combined induction mode of continuous white light illumination and superposition of blue light irradiation and pentyltetrazole treatment in the period, so that rapid induction of the insomnia phenotype of the zebra fish is realized. According to the method, environment and chemical factor synergistic induction is combined, and the insomnia degree is represented through multi-dimensional indexes. The zebrafish insomnia model is successfully and stably established, and the zebrafish insomnia model can be used for screening medicines or foods for improving insomnia caused by synergistic effects of environment and chemical factors, and has the advantages of short period, comprehensive phenotype and high reproducibility.

The invention discloses a device for assisting in relieving depression and insomnia of teenagers through traditional Chinese medicine acupoint application, the device comprises a flexible application module, an intelligent control system and a wearable monitoring system, the intelligent control system comprises a slow-release adjusting module, a Bluetooth module and a timing setting module, the slow-release adjusting module is used for controlling a micro-fluidic chip to release medicine, and the Bluetooth module is used for controlling the micro-fluidic chip to release medicine; the Bluetooth module is used for interconnection control with a user mobile phone APP, the timing setting module controls the micro-fluidic chips at different positions to release drugs in different time periods based on the user mobile phone APP, and the wearable monitoring system is composed of a wearable bracelet and a sensor; by designing the flexible application module which intelligently controls the effect of applying to the specific acupuncture points of the human body, the medicine application time and dosage can be automatically controlled, the transdermal efficiency of traditional Chinese medicine ingredients is improved through the physical infiltration promotion technology in cooperation with the microneedle array, and meanwhile the skin sensitivity of teenagers is prevented from being damaged by adopting a low-sensitization adhesive; and the device can realize intelligent adjustment of medicine application, and realizes personalized assistance of slow depression and insomnia symptoms.

The invention discloses a food composition with effects of relieving pressure and helping sleep as well as a preparation method and application of the food composition, and belongs to the technical field of compositions. The traditional Chinese medicine composition comprises the following raw materials in parts by weight: 8-12 parts of balm, 6-10 parts of gastrodia elata powder, 6-10 parts of lucid ganoderma powder, 2-5 parts of eucommia male pollen, 1-3 parts of spina date seed powder, 1-3 parts of poria cocos powder and 6-10 parts of gamma-aminobutyric acid. According to the traditional Chinese medicine composition, aiming at insomnia syndromes in traditional Chinese medicine, through mutual cooperation of multiple targets, body functions are adjusted from multiple aspects, insomnia disorders caused by malnutrition, unease, liver depression, qi stagnation and the like are improved, meanwhile, the traditional Chinese medicine composition has a good improvement effect on sleep disorders caused by imbalance of neurotransmitters and sleep problems caused by pressure, and compared with the prior art, the traditional Chinese medicine composition has the advantages that the traditional Chinese medicine composition is worthy of popularization and application. The traditional Chinese medicine composition comprehensively improves the insomnia symptom through multiple mechanisms, and has the advantages of safety, no side effect, reliable curative effect, wide application range and the like.

The present invention provides a Chinese medicine composition for treating insomnia caused by liver depression and fire syndrome. The present invention enriches, purifies and compates Chinese medicine prescriptions according to the compatibility principle of traditional Chinese medicine to effectively treat insomnia caused by liver depression and fire syndrome. The results of animal experiments show that the effect of the Chinese medicine composition provided by the present invention on treating insomnia caused by liver depression and fire syndrome is significantly better than that of the original prescription.

The invention provides a traditional Chinese medicine composition for treating insomnia and application thereof. The traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 12-18 parts of spiny jujube seeds, 8-12 parts of platycladus seeds, 8-12 parts of scutellaria baicalensis, 10-14 parts of phellodendron amurense, 7-11 parts of pinellia ternata, 2-4 parts of cinnamon bark, 8-12 parts of bamboo shavings, 7-11 parts of radix polygoni multiflori, 8-12 parts of tangerine peel, 8-12 parts of coix seeds, 8-12 parts of yam, 20-26 parts of tortoise shells and 26-34 parts of raw oysters. The present invention studies the effect of the above-mentioned Chinese medicine composition on the mRNA expression of tryptophan hydroxylase 2 (TPH2), a key protein of the central 5-HT synaptic signaling pathway, and the 5-HIAA content and the 5-HIAA / 5-HT ratio of the 5-HIAA transporter (Slc6a4) in the rat model of insomnia with spleen deficiency syndrome caused by complex factors. The results show that the Chinese medicine composition can up-regulate the mRNA expression of TPH2 and Slc6a4 in the dorsal raphe nucleus of the rat model of insomnia with spleen deficiency syndrome, and up-regulate the 5-HIAA content and the 5-HIAA / 5-HT ratio, thereby finally improving the insomnia symptoms.

The invention discloses a traditional Chinese medicine composition for treating anxiety insomnia. The traditional Chinese medicine composition is prepared from, by weight, 3-5 parts of rhizoma coptidis, 3-6 parts of cortex cinnamomi, 5-8 parts of fructus aurantii immaturus, 5-10 parts of radix curcumae, 5-8 parts of radix polygalae, 5-10 parts of fructus schizandrae, 5-8 parts of rhizoma chuanxiong and 1-3 parts of borneol. The traditional Chinese medicine composition can be used for preparing an external preparation navel patch, and the navel patch can be absorbed through the Shenque acupoint to play a whole regulation role. The navel patch disclosed by the invention has a remarkable curative effect on anxiety emotion caused by heart-kidney disharmony and qi stagnation and secondary anxiety insomnia symptoms such as difficulty in falling asleep, vexation, insomnia, dreaminess and easy awakening, is safe and convenient to use, provides a new solution for an external treatment method of anxiety insomnia, and has relatively high application and popularization values.

The invention belongs to the technical field of traditional Chinese medicine individuation, and provides a synergistic effect method of a traditional Chinese medicine dosage gradient scheme in insomnia treatment based on prescription dosage-efficiency science, which comprises the following steps: performing traditional Chinese medicine syndrome differentiation and typing on patients, and matching corresponding basic prescriptions according to syndromes; collecting individual characteristic parameters of a patient, and calculating an initial dose of traditional Chinese medicine according to the individual characteristic parameters; in the treatment cycle, the insomnia severity index and the Pittsburgh sleep quality index are adopted for curative effect evaluation, safety monitoring is conducted in combination with blood routine examination and liver and kidney function detection, and an evaluation result is obtained; according to an evaluation result, combining pharmacokinetic parameters, dynamically adjusting the dosage of the traditional Chinese medicine, and forming a dosage gradient scheme; synchronizing real-time lifestyle intervention and psychotherapy; through deep combination of the traditional Chinese medicine dialectical theory and modern pharmacokinetics, digital modeling and dynamic regulation and control are carried out on the dose-effect relationship of the traditional Chinese medicine, and the accuracy, safety and long-term curative effect of the traditional Chinese medicine for treating insomnia are ensured.

The invention discloses an anhypnia traditional Chinese medicine five-tone music generation method and system based on an adversarial neural network, and a medium, and the method comprises the steps: receiving traditional Chinese medicine syndrome type information corresponding to anhypnia input by a user, mapping a traditional Chinese medicine music prescription knowledge base based on preset elements, and generating a corresponding music direction vector; inputting the music orientation vector as a condition vector into an adversarial neural network, wherein the adversarial neural network outputs a music matrix corresponding to the music orientation vector; and rendering the music matrix, and outputting the traditional Chinese medicine five-tone treatment music. Differentiated customization is realized according to different syndrome type information, so that traditional Chinese medicine five-tone treatment music with higher pertinence and more stable effect is provided for insomnia patients.

A sublingual phentermine spray composition for daytime use comprises phentermine in a pharmaceutically-acceptable carrier and a sublingual phentermine spray composition for nighttime use comprises phentermine and a sleep aid in a pharmaceutically-acceptable carrier. Sublingual administration of sublingual phentermine spray compositions in accordance with the present disclosure provides an alternative to oral administration, avoiding such side effects as daytime drowsiness and intestinal disturbances. Nighttime use compositions comprising a sleep aid such as melatonin help manage the usual insomnia experienced when using phentermine. These compositions find use in suppressing appetite, for losing weight, and for maintaining a desired personal appearance.

The invention provides fructus podophylli jelly with the efficacy of improving qi deficiency and blood stasis and a preparation method of the fructus podophylli jelly. A traditional Chinese medicine composition is prepared from the following raw medicinal materials in parts by weight: 12-18 parts of spina date seeds, 8-12 parts of platycladi seeds, 8-12 parts of radix scutellariae, 10-14 parts of cortex phellodendri, 7-11 parts of rhizoma pinelliae preparata, 2-4 parts of cortex cinnamomi, 8-12 parts of caulis bambusae in taeniam, 7-11 parts of caulis polygoni multiflori, 8-12 parts of pericarpium citri reticulatae, 8-12 parts of coix seeds, 8-12 parts of Chinese yams, 20-26 parts of tortoise shells and 26-34 parts of raw oysters. By researching the influence of the traditional Chinese medicine composition on mRNA expression and 5-HIAA content of key egg white amino acid hydroxylase 2 (TPH2) and 5-HT transporter (Slc6a4) of a central 5-HT synaptic signaling pathway of a spleen-deficiency syndrome insomnia model rat caused by complex factors and a 5-HIAA / 5-HT ratio, the invention shows that the traditional Chinese medicine composition can be used for treating insomnia caused by spleen deficiency syndrome caused by complex factors. The traditional Chinese medicine composition can up-regulate the mRNA expression of TPH2 and Slc6a4 in the dorsal nucleus of a spleen deficiency syndrome insomnia model rat, up-regulate the content of 5-HIAA and the ratio of 5-HIAA to 5-HT, and finally improve the insomnia symptom.

The invention discloses a method and device for predicting the curative effect of depression with insomnia and a storage medium, and the method comprises the steps: finding a core medication strategy through the drug proportion, association strength and drug compliance, and constructing a model for predicting the curative effect of a core treatment scheme on a patient with depression with insomnia in a real diagnosis and treatment environment; and high-quality evidence is provided for personalized treatment of patients with depression. The method comprises the following steps: acquiring a medical record data set of a patient, and performing dimensionality reduction fitting on medical record data in the medical record data set to obtain a low-dimensional treatment scheme set; after calculating the similarity of the low-dimensional treatment schemes, dividing the low-dimensional treatment schemes into a plurality of groups of treatment schemes according to preset conditions; multiple groups of treatment schemes are verified through prospective follow-up visit, the relevance between medication modes of different follow-up visit points and insomnia symptoms or sleep quality is analyzed, and a core treatment scheme set is obtained; constructing a curative effect prediction model according to the core treatment scheme set and the time for controlling the illness state of the patient; and inputting medical record data of a to-be-detected patient to the curative effect prediction model to obtain a recommended treatment scheme.

The invention discloses a smoked plum compound medicine capable of helping sleep and improving insomnia symptoms, which comprises the following components in parts by mass: 30 parts of smoked plum, 3 parts of asarum, 5 parts of light dried ginger, 10 parts of coptis chinensis, 4 parts of angelica sinensis, 6 parts of peeled radix aconiti lateralis praeparata, 4 parts of pericarpium zanthoxyli, 6 parts of peeled cassia twig, 10 parts of codonopsis pilosula and 6 parts of golden cypress, and preferably, the components are processed to obtain granules. According to the invention, the dark plum pill is taken as a basic formula, the medicines are replaced, and the dosage is increased or reduced, so that the sleep can be promoted, insomnia symptoms such as depression, anxiety, spatial learning and memory ability and the like are effectively improved, the original effects and major functions of the dark plum pill formula are changed, and an unexpected technical effect is generated. Compared with the existing medicament for treating insomnia, the medicament has the advantages of safety in administration, small side effect, good effect and the like.

The invention discloses a wild jujube cake and a preparation method thereof, relates to the technical field of homology of medicine and food, and adopts the technical scheme that the wild jujube cake is prepared from 3 parts of fried spina date seeds, 3 parts of wine steamed mulberries, 1 part of salt steamed black beans, 1 part of nine-steamed nine-sun-dried black sesames and 4 parts of refined honey. The traditional Chinese medicine can tonify the liver and the kidney, is used for treating insomnia, alopecia and leukotrichia caused by deficiency of liver blood, and particularly has a relatively obvious effect on senile insomnia and climacteric insomnia.

The invention discloses a deuterated amide compound and a preparation method and application thereof, and belongs to the technical field of medicines, deuterated amides shown in the formula I or pharmaceutically acceptable salts thereof have orexin receptor antagonism, and can be used for preparing medicines for treating sleep disorders such as insomnia. Compared with the commercially available drugs, the deuterated amide compound provided by the invention has better pharmacokinetic characteristics. And more choices are provided for clinical treatment of sleep disorder diseases. # imgabs0 #

The invention belongs to the technical field of traditional Chinese medicine compounds, and provides a depression-resolving and nerve-calming formula for treating insomnia and relieving anxiety and a preparation method thereof, the depression-resolving and nerve-calming formula comprises the following raw materials: 10-30 parts of radix curcumae, 8-24 parts of radix asparagi, 5-15 parts of flos albiziae, 2-6 parts of cortex cinnamomi, 1-3 parts of semen ziziphi spinosae, 1-3 parts of magnetite and 1-3 parts of amber; the depression-resolving and nerve-soothing compound prescription can effectively improve the physical conditions such as eating, hair color and weight of rats with insomnia; the sleep latency period of rats with insomnia is shortened, the sleep duration is prolonged, and the in-vivo 5-HT level is adjusted, so that an exact treatment effect on insomnia is achieved; for a depression rat model, the total activity distance of depression rats can be effectively increased, and the autonomous swimming time and the tail suspension struggling time are prolonged.

The invention relates to application of a traditional Chinese medicine composition in preparation of a medicine for treating insomnia. The traditional Chinese medicine composition is prepared from the following raw material medicines in parts by weight: 5-25 parts of ligusticum wallichii and 1.5-8 parts of gastrodia elata. The traditional Chinese medicine composition disclosed by the invention has certain sedative and hypnotic effects and can exert a curative effect on insomnia.

The present application provides a composition comprising probiotics and its use for treating insomnia. Further, the present application also provides a dual orexin receptor antagonist polypeptide O-59 polypeptide, which can inhibit the over-activation of the orexin system by antagonizing the orexin 1 receptor (OX1R) and the orexin 2 receptor (OX2R), thereby improving sleep. After the polypeptide is combined with the probiotic composition, the insomnia symptoms of the insomnia mice can be significantly improved, and the application prospect is good.

Pharmaceutical compositions comprising ebastine and alprazolam are disclosed. Methods of using the pharmaceutical compositions for treating patients suffering from insomnia are also disclosed.

The invention discloses a tongue exercise and respiration collaborative conditioning method for improving refractory insomnia, and relates to the field of human health conditioning and sleep medicines.The method comprises the steps that tongue exercise exercise of a preset duration is executed in the period before sleep every day, abdominal or inverse abdominal respiration regulation is conducted in a synchronous and matched mode, and therefore tongue muscle groups are activated. In the morning or before afternoon every day, a skin needle therapy (oblique puncturing for 0.5 mm) and a bloodletting therapy are performed on specific acupuncture points (such as Yingwei points) in the oral cavity so as to activate and disperse blood stasis and increase qi and blood flow. Through the synergistic effect of lingual exercise, breathing conditioning and skin needle / bloodletting therapy, the blood supply state of the brain and the heart is improved, so that the intractable insomnia symptom caused by neurasthenia, physical weakness, cardio-cerebral ischemia and the like is relieved from the source. The method emphasizes multi-dimensional collaborative conditioning, can adapt to different crowds, can be dynamically adjusted through effect evaluation, and aims to realize a physical insomnia intervention mode without drug dependence.

The invention discloses a traditional Chinese medicine heart nourishing and nerve soothing formula for treating insomnia. The formula is composed of spina date seed, mulberry, dendrobium, trichosanthes peel, cassia seed, dark plum, poria with hostwood and green plum blossom. The heart-nourishing and mind-tranquilizing formula is mainly used for nourishing the heart, tranquilizing the mind, nourishing yin, clearing heat, soothing the liver and relieving depression, and spina date seeds and poria with hostwood in the formula are used as monarch materials to nourish heart yin, tranquilize the mind, stabilize the mind and Mulberry, dendrobium and dark plum are used as ministerial drugs to nourish yin, promote salivation, clear deficiency heat and improve dysphoria, night sweat and dry mouth caused by fire excess from yin deficiency. The semen cassiae has the effects of clearing liver fire and relaxing bowel, and the semen cassiae and the semen cassiae can assist in clearing away the heart-fire and reducing phlegm; the green plum blossom can soothe liver depression without hurting yin, and is capable of soothing liver, harmonizing stomach and regulating qi. The prescription is used for overall conditioning of complex pathogenesis (yin deficiency, liver depression and phlegm heat) of insomnia, and is especially suitable for people with insomnia caused by high pressure, unsmooth emotion and staying up late at present. Compatible medication has local characteristics of new-safety medicine, is particularly beneficial to improvement of insomnia symptoms and the like, and is definite in curative effect and free of toxic and side effects.

The present invention relates to a method of treating insomnia in a subject in need thereof, comprising administering to the subject a therapeutically effective amount of certain carbamate compounds.

1. The name of the design product: transcranial micro-current stimulation instrument. 2. The use of the design product: for assisting to improve insomnia symptoms. 3. The design points of the design product: in shape. 4. The picture or photo that best indicates the design points: perspective view 1.

The application discloses an oral preparation capable of improving 5-HT level in the brain and application thereof in improving insomnia, and belongs to the field of food science. The oral preparation uses starch and beta-cyclodextrin as nanoparticle carriers to wrap 5-HTP, can effectively control the release rate of 5-HTP, makes it slowly release in the gastrointestinal tract, and improves the defect that the half-life of 5-HTP is short. The preparation can significantly improve the content of 5-HT in the brain, and improve the metabolic kinetic characteristics of 5-HT, thereby effectively improving the insomnia symptoms. Experimental data shows that, compared with the traditional 5-HTP, the slow-release preparation has better bioavailability and longer brain drug efficacy duration. The innovative preparation not only has significant advantages in technology, but also opens up a new, safe and effective way for the treatment of 5-HT related nervous system diseases, and has important application value and research significance.

The invention provides a composition for preventing or improving sleep disorders and a preparation method and application thereof, and belongs to the technical field of medicine and health care. The composition is prepared from the following raw material components in parts by weight: 3 to 36 parts of radix salviae miltiorrhizae, 2 to 30 parts of radix notoginseng, 3 to 36 parts of semen ziziphi spinosae and 1 to 30 parts of fructus phyllanthi. Tibetan red sage root, Tibetan pseudo-ginseng, spina date seed and emblic leafflower fruit are compatible and can synergistically play a synergistic role in promoting blood circulation to remove blood stasis, nourishing blood and tranquilizing, dispersing blood stasis and stopping bleeding, diminishing swelling and relieving pain, nourishing heart and benefiting liver, tranquilizing and arresting sweating and the like, and the blood stasis type insomnia symptom can be effectively improved.

The invention provides a spleen-tonifying, kidney-tonifying and nerve-calming formula for renal insufficiency with insomnia and a preparation method thereof. The spleen-tonifying, kidney-tonifying and nerve-calming formula comprises the following components: 15g of codonopsis pilosula, 15g of poria with hostwood, 10g of rhizoma pinelliae preparata, 8g of angelica sinensis, 5g of liquorice, 12g of longan aril, 5g of cinnamon, 5g of coptis chinensis and 10g of spina date seed. Aiming at patients with renal insufficiency with insomnia, the formula disclosed by the invention is beneficial to improving the sleep quality of the patients with renal insufficiency through the effects of tonifying spleen, tonifying kidney and soothing nerves, and has a relatively good effect of relieving the insomnia symptom of the patients with renal insufficiency. By improving the sleep quality, the overall life quality and mental state of the patient with renal insufficiency can also be improved. The spleen-tonifying, kidney-tonifying and nerve-calming formula for treating renal insufficiency with insomnia can effectively improve sleep quality and relieve traditional Chinese medicine syndromes, and is beneficial to improving the sleep quality of patients and relieving insomnia symptoms for the patients with renal insufficiency with insomnia.