53 results about "PARKINSON'S SYNDROME" patented technology

The invention provides a dihydromyricetin-containing plant extract and application thereof as a superactive catechol methylation transferase inhibitor. The dihydromyricetin-containing plant extract is applicable as a synergist of a medicine levodopa treating Parkinson's syndrome. In-vitro activity determination shows that IC50 of the plant extract inhibiting catechol methylation transferase can reach the micro-mole to nano-mole grade. Rat integral pharmacokinetic research shows that combined usage of dihydromyricetin and levodopa containing the dihydromyricetin-containing plant extract can substantially improve the plasma concentration of levodopa. Additionally, dihydromyricetin and the dihydromyricetin-containing plant extract are high in safety, do not generate active intermediates through metabolism activation, do not combine with a biomacromolecule to form a toxic adduct, and therefore dihydromyricetin and the dihydromyricetin-containing plant extract do not cause liver and kidney toxicity, and are expected to have good application prospect in auxiliary treatment of Parkinson's syndrome.

The invention relates to a Parkinson's syndrome aided prediction method based on a multi-label model. Prediction model building, balance evaluation and mining prediction stage processing modules are included. In the prediction model building module, a main syndrome is selected; K secondary syndromes are selected; the main syndrome and the K secondary syndromes form a new syndrome set; the balance of the syndrome set is evaluated; if the balance meets the conditions, the relevance between the main syndrome and the secondary syndromes is determined, and otherwise, the second step is carried out again; the syndrome set serves as training data to build the multi-label model. In the balance evaluation module, obtained syndrome sets are combined; the number and occurrence frequency of the syndrome combinations are counted; according to an information entropy formula, the entropy of the syndrome sets is calculated; the process is ended. In the prediction stage, the given to-be-predicted data are transmitted to the model to be classified; all the classification results of the model are voted, and a final prediction result is obtained. The method solves the problem that a multi-label classification algorithm is not accurate in prediction under sparse category and unbalanced conditions.

An agent for preventing and / or treating Parkinson's disease or Parkinson's syndrome, comprising, as an active ingredient, an astrocyte function-improving agent is disclosed. The astrocyte function-improving agent is preferably a compound represented by formula (I), a non-toxic salt thereof, or a hydrate thereof: R5, R6, R11 and n are defined in the specification.

The invention provides a selective M4 receptor antagonist--levorotation demethylation phencynonate, non-toxic medicine salt thereof, medical composition that contains the levorotation demethylation phencynonate and non-toxic salt as active ingredients and application thereof in preparation of therapeutic drugs for motility dysfunctions of fremitus, rigor, etc. caused by Parkinson's syndrome (PD). The structure of the composition is showed in formula IIa.

The embodiment of the invention discloses a traditional Chinese medicine composition for treating Parkinson's syndrome and a preparation method thereof, and relates to the technical field of traditional Chinese medicine. The traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 30-50 parts of calculus bovis, 50-80 parts of stir-fried cape jasmine, 50-80 parts of cortex phellodendri processed with wine, 45-55 parts of radix scutellariae, 40-55 parts of rhizoma picrorhizae, 100-150 parts of prepared whole worms, 50-80 parts of ligusticum chuanxiong prepared with semen lepidii, 50-80 parts of radix salviae miltiorrhizae prepared with semen lepidii, 100-120 parts of rhizoma gastrodiae, 100-120 parts of salt-fried eucommia ulmoides, 30-50 parts of radix achyranthis bidentatae, 100-150 parts of calcined oysters, 50-80 parts of leeches processed with wine, 50-80 parts of centipedes processed with wine, 40-60 parts of uncaria rhynchophylla, 100-150 parts of white paeony root stir-fried with bran, and 50-80 parts of prepared bombyx batryticatus. The traditional Chinese medicine composition for treating Parkinson's syndrome is capable of harmonizing qi and blood, nourishing Yang and tonifying kidney, dredging collaterals and relieving pain, dredging and nourishing governor and conception vessels, nourishing brain and improving intelligence, balancing Yin and Yang of human body, and making qi and blood dredged, has the advantages of obvious curative effect, high safety and no toxic or side effects, and is suitable for long-term taking.

The invention discloses a drug for treating symptoms of a later stage of chronic manganese poisoning. The drug is prepared from following raw herbal materials: herbs of indian abutilon, tall gastrodia tuber, Acorus gramineus Soland, altai anemone roots, chrysanthemum, oxygraphis glacialism, Chinese honey locust, bayberry roots, aquilariaceae malaccensis, bulbiferous stonescrop, tung tree roots, canscora, stem and leaves of cryptotaenia japonica hassk, puncturevine caltrop fruits, Saffron, Cyperus cyperoides, jasmine flowers, scabrousstem greenbrier rhizomes melitodes squamata nutting, asplenium incisum Thunb, murraya jasminorage, roots or stem of evergreen mucuna, aconiteleaf syneilesis herbs, fiddle-leaf fig roots and Japanese saussurea. The drug has the benefits as follows: the drug can be applied to treatment of the later stage of chronic manganese poisoning, Parkinson's syndrome, four-limb hypermyotonia, static tremor, lalopathy, gait difficulty and the like as well as mental symptoms including involuntary crying and laughing, obsessive thoughts, impulsive behaviors and the like can be relieved very well through drug therapy, the symptoms are eliminated through body regulation, so that the symptoms after poisoning are relieved very well, and the condition of a patient is greatly improved.

The present invention relates to methods for diagnosing a Parkinson's syndrome (PS), Parkinson's disease (PD), or Parkinsonism in an individual. Further, the present invention relates to a method for differential diagnosing between PD and Parkinsonism. Furthermore, the present invention relates to methods for monitoring the course of a Parkinson's syndrome, Parkinson's disease (PD), or Parkinsonism in an individual. In addition, the present invention relates to kits suitable to carry out the above described methods.

The invention relates to the use of a substance, which binds to and initiates signaling of the human growth hormone (hGH) receptor or a substance, which stimulates release or potentiates the activity of endogenous hGH, for treatment and / or prevention of Parkinsonism-Plus Syndromes. In particular, the invention relates to the use of hGH for the treatment and / or prevention of Multiple System Atrophy.

The invention discloses a processing method of a flexible vibration sensor for monitoring Parkinson syndrome. The processing method includes the following steps of spin-coating photoresist, exposure,development, evaporation Ni film, removing glue and cleaning, growing CA self-crosslinking array, transferring to flexible substrate, clean and stripping, and sensor production. The flexible vibrationsensor produced by the processing method has the advantages of low power consumption, high stability and high sensitivity, so that the flexible vibration sensor has huge application potential in wearable health monitoring and has great potential in the direction of manufacturing low-cost and durable flexible sensors.

The invention discloses a pharmaceutical composition, which is a preparation prepared from raw materials in the following weight proportions: 6-60 parts of rehmannia glutinosa, 5-50 parts of Gastrodia elata, and 1-15 parts of scorpion. The invention also provides the preparation method and application of the pharmaceutical composition. Pharmacological tests have proved that the pharmaceutical composition of the present invention can significantly improve the symptoms of Parkinson's syndrome, and can effectively treat Parkinson's syndrome; there is toxicity in the scorpion in the prescription, and its toxic and side effects can be reduced after the compatibility of the present invention. The pharmaceutical composition of the present invention The medicine is accurate and appropriate, the cost is low, the preparation method is simple, and the preparation method is suitable for large-scale production.

The invention provides a plant extract of the genus Zanthoxylum and its preparation method and application. The plant extract of the genus Zanthoxylum is extracted and refined from the peel of the plant of the genus Zanthoxylum L., and its total polyphenol content is 50-80%. 15%. The Zanthoxylum plant extract is combined with a pharmaceutically acceptable carrier or other suitable excipients, and made into oral, injection or other dosage forms according to conventional methods, which can be used for the prevention and treatment of stroke, Parkinson's syndrome, Hypertension, hyperlipidemia, atherosclerosis, coronary heart disease and other cardiovascular and cerebrovascular diseases.

The present invention is directed to a therapeutic method of independent or adjuvant treatment of Parkinson's disease and Parkinson's syndrome, comprising administering to a subject in need a therapeutically effective amount of Chinese medicine composition, wherein the Chinese medicine composition comprises the extract of the mixture of Rhizoma Pinelliae, Rhizoma Atractylodis Macrocephalae, Poria, Radix Glycyrrhizae, Rhizoma Atractylodis, Rhizoma Alismatis, Pericarpium Citri Reticulatae, Massa Medicata Fermentata, Fructus Hordei Germinatus, Rhizoma Zingiberis, Cortex Phellodendri, rhizoma Gastrodiae, Radix Aconiti Lateralis Praeparata, Radix Angelicae Sinensis, and Radix Astragali.

The invention discloses a writing structure for patients with parkinsonian syndromes. The writing structure comprises an execution part and an end head part, wherein the execution part comprises an outer frame, an X-directional motion cross brace and a Y-directional motion cross brace, wherein the outer frame is in a square circular shape; a square circular shaped sliding slot is formed in the side wall of a square circular inner ring; the square circular shaped sliding slot comprises a pair of parallel X-directional sliding slots and a pair of parallel Y-directional sliding slots; the X-directional sliding slots are orthogonal to the Y-directional sliding slots; the two ends of the X-directional motion cross brace are separately arranged in the pair of X-directional sliding slots and aremoved along the X-directional sliding slots; and the two ends of the Y-directional motion cross brace are separately arranged in the pair of Y-directional sliding slots and are moved along the Y-directional sliding slots. According to the writing structure for the patients with the parkinsonian syndromes, through arrangement of the structure, static tremor caused by the parkinsonian disease can bedealt simultaneously with myotonia caused by the parkinsonian disease, so that writing can be completely and continuously finished in hands of the patients with the parkinsonian syndromes, and thus,requirements of the patients can be met.

Provided is a levodopa prodrug that overcomes the problems attributed to the blood kinetics of levodopa such as large number of doses and the incidence of side effects due to frequent dosing. (2S)-2-Amino-3-(3,4-bis((2-(benzoyloxy)-2-methylpropanoyl)oxy)phenyl)propanoic acid, a salt thereof, or a solvate thereof is a levodopa prodrug, and provides a flat blood concentration-time profile of levodopa through oral administration, and therefore is useful as a preventive and / or therapeutic agent for Parkinson's disease and / or Parkinson's syndrome that overcomes the problems associated with pharmaceutical preparations of levodopa.

The invention discloses a French marigold herb. The French marigold herb is applied to medicinal electuary; and the French marigold herb has the efficacy of resisting to inflammation and reducing internal heat, and has improvement and prevention effects on prostatitis, gastrointestinal ulcer, Parkinson's syndrome, epilepsy, depression, climacteric syndrome, rhinitis, common cold due to wind-heat,pertussis, dysentery, costal gland diseases, mammary welling-abscess, furuncle, toothache, stomatitis, swelling and pain of eyes and adolescent acne. Steps of making the electuary by adopting the whole French marigold herb mainly include as follows: taking the whole French marigold herb to clean; performing air-drying and crushing into powder; and compacting the powder into small granules, and performing packaging and sealing. As the French marigold herb can be applied to the electuary, various functions of the French marigold herb can be integrated, so that people can obtain various efficacyof the French marigold herb by taking the electuary, and therefore, health care purposes can be achieved.