64 results about "Taking blood sample" patented technology

A device (302) for sampling and / or analyzing blood or other body fluid of a subject. A housing (306) contains a plurality of lancets (308) and optionally includes test elements (324) to take up a sample of blood, an evaluation system and a display. A complete system that can be handled as a single device, for example in the form of a wristwatch, includes a multiplicity of test elements (324) and lancets (308), which can be brought successively to a working position to perform multiple measurements. A cassette or carrier (320) includes multiple lancets (308) and / or test elements (324), for insertion into the device.

A device for sampling and / or analyzing blood or other body fluid of a subject. A housing contains a plurality of lancets and optionally includes test elements to take up a sample of blood, an evaluation system and a display. A complete system that can be handled as a single device, for example in the form of a wristwatch, includes a multiplicity of test elements and lancets, which can be brought successively to a working position to perform multiple measurements. A cassette or carrier includes multiple lancets and / or test elements, for insertion into the device.

A lancet device, a tip for a lancet device and method of using the lancet device. The lancet device has a body portion for firing the lancet and a tip portion. The tip for a lancet device includes a front assembly which includes a side wall portion, a skin-engaging portion at least partially defining a plane beyond which a lancet needle may extend, and a lancet stop element, a slot is disposed in one of the sidewall portion and the lancet stop element, and at least one following element extending into the slot, wherein the lancet stop element is moveable towards and away from the plane in response to movement of the at least one following element. The method includes adjusting a set depth of penetration of the needle by moving the at least one following element, disposing the distal end of the lancet device against a surface of skin, and triggering the firing mechanism to cause the needle to penetrate the surface of the skin to the set depth, wherein the puncture allows a blood sample to be taken.

This application describes designs, implementations, and techniques for optically monitoring glucose levels of patients without taking blood samples.

A kit containing all the materials needed to take a blood sample from a neonatal patient, a pediatric patient, a juvenile patient or an adult patient. The materials are supplied in a plastic package suitable for sterilization.

A method and apparatus for reducing user anxiety in the taking of a sample of blood. The apparatus comprises a lancing device that includes a housing and a disposable cartridge. The disposable cartridge is replaceably installed in the housing and includes a plurality of lancets within an outer shell which is effective for keeping the lancets hidden from view during loading and unloading of the disposable cartridge to and from the housing and during use of the lancing device.

A lancing device is adapted for use in firing a lancet into the skin of a patient to acquire a blood sample and, subsequent thereto, calculating and displaying the concentration of glucose in the acquired sample. In one embodiment, the device comprises a lancet and a torsion spring coupled to the lancet through a lancet holder. The torsion spring includes inner, middle and outer rings which are concentrically configured, a plurality of activation spring arms which connect the middle and outer rings and a plurality of return spring arms which connect the inner and middle rings. In use, the plurality of activation and return spring arms can be independently transformed between energized and de-energized states using a single, button-shaped mechanism. Rotation of the mechanism is used to energize the activation and return spring arms. With the return spring arms maintained in their energized state, depression of the mechanism transforms the activation spring arms from their energized state to their de-energized state which drives the lancet from a retracted position to an extended position. Once the activation spring arms reach their de-energized state, the return spring arms transform from their energized state to their de-energized state which pulls the lancet back from its extended position to its retracted position.

The present invention relates to a method for fabricating a hollow microneedle having a variable appearance. The method makes it possible to vary the length of the microneedle, the outer and inner diameters of the upper and lower parts thereof, the aspect ratio, the sharpness, and the structural bending rate thereof, in accordance with the purposes of the same. Accordingly, the appearance of the hollow microneedles according to the present invention can be varied with flexibility according to various purposes, such as the transferring of medication and the taking of a blood sample, and to various factors, such as the target part for the medication transfer, the depth of the medication transfer, and the amount and viscosity of the medication. Thus, the microneedle can be used as a multi-purpose device for transferring medication.

A disposable, closed fluid sampling system for use with a medical conduit line, especially for taking blood samples from a pressure monitoring line. The conduit line has at least one fluid sampling site interposed between a distal segment of tubing and a proximal segment of tubing. The system includes a disposable subsystem having a bypass cannula adapted to engage the sampling site, a reservoir for drawing a prime volume of fluid past the sampling site, and a fluid sampling container. A 3-way stopcock may connect the reservoir, bypass cannula, and sampling vessel for controlling the sampling procedure. The bypass cannula may simultaneously place the subsystem into fluid communication with an inner chamber of the sampling site and exclude the proximal segment of the conduit line. Alternatively, a stopcock immediately adjacent the sampling site in the proximal segment may be utilized. A method of using the system includes attaching the disposable subsystem, opening the reservoir to the distal segment while excluding the proximal segment, drawing a prime volume of fluid into the reservoir, opening the sampling vessel to the distal segment and drawing a sample, re-infusing the prime volume into the distal segment, and removing and discarding the subsystem. The reservoir remains attached between the prime volume draw and re-infusion and is thus “closed.”

Novel devices which can be used to both collect blood samples from and administer medical fluids to a patient on a repeated and continual basis using one rather than multiple needle insertions. The device typically includes a main tubing segment confluently connected to a cannula for insertion in the patient's vein. A syringe port and a volumeter for collecting blood branch separately from the main tubing segment. The device is used to collect blood by attaching an empty blood collection syringe to the syringe port, inserting the cannula in the patient's vein, allowing passive flow of blood from the main tubing segment into the volumeter under intrinsic venous blood pressure and capillary action, and then facilitating active flow of blood from the volumeter into the blood collection syringe by extending the syringe plunger. The device may be used to administer medical fluids to the patient through the main tubing segment from a medical fluid syringe or catheter attached to the syringe port.

A blood collection needle assembly includes a holder body having a tube receiving chamber and a needle receiving chamber. A proximal needle is mounted to the holder body and projects into the tube receiving chamber. A distal needle is slidably mounted in alignment with the needle receiving chamber. A spring is provided to urge distal needle into the needle receiving chamber, and a trigger is provided for selectively permitting or preventing proximal movement of the distal needle. A transverse passage between the two needles is formed from a transparent material and provides indication of venus axis. The blood collection needle assembly is used to collect a sample of blood in a conventional manner. After collection of the blood, the trigger is actuated to release the distal needle and the spring propels the distal needle in a proximal direction for safe shielding within the needle receiving chamber of the holder body.

Novel devices which can be used to both collect blood samples from and administer medical fluids to a patient on a repeated and continual basis using one rather than multiple needle insertions. The devices are capable of removing blood from one of the patient's veins using the intrinsic venous pressure of the blood and capillary action of the device, thereby preventing vacuum-induced collapse of the vein. The device typically includes a main tubing segment confluently connected to a cannula for insertion in the patient's vein. A syringe port and a volumeter for collecting blood branch separately from the main tubing segment. The device is used to collect blood by attaching an empty blood collection syringe to the syringe port, inserting the cannula in the patient's vein, allowing passive flow of blood from the main tubing segment into the volumeter under intrinsic venous blood pressure and capillary action, and then facilitating active flow of blood from the volumeter into the blood collection syringe by extending the syringe plunger. The blood-filled syringe may be replaced by additional empty blood collection syringes and the procedure repeated, as needed, depending on the quantity of blood to be obtained. The device may be used to administer medical fluids to the patient by first removing the residual blood from the main tubing segment and volumeter, flushing the main tubing segment with sterile normal saline and administering the fluids to the patient through the main tubing segment from a medical fluid syringe or catheter attached to the syringe port.

A disposable, closed fluid sampling system for use with a medical conduit line (70), especially for taking blood samples from a pressure monitoring line. The conduit line (70) has at least one fluid sampling site (100, 102) interposed between a distal segment of tubing and a proximal segment of tubing. The system includes a disposable subsystem (96) having a bypass cannula (110) adapted to engage the sampling site, a reservoir (112) for drawing a prime volume of fluid past the sampling site, and a fluid sampling container (114). A 3-way stopcock (116) may connect the reservoir, bypass cannula, and sampling vessel for controlling the sampling procedure. The bypass cannula (110) may simultaneously place the subsystem into fluid communication with an inner chamber (136) of the sampling site and exclude the proximal segment of the conduit line. Alternatively, a stopcock immediately adjacent the sampling site in the proximal segment may be utilized. A method of using the system includes attaching the disposable subsystem, opening the reservoir to the distal segment while excluding the proximal segment, drawing a prime volume of fluid into the reservoir, opening the sampling vessel to the distal segment and drawing a sample, re-infusing the prime volume into the distal segment, and removing and discarding the subsystem. The reservoir remains attached between the prime volume draw and re-infusion and is thus 'closed'.

The invention relates to a normal pulse stripping method for detecting the content of vitamin in blood samples, belonging to the technical field of vitamin analysis and detection. The method is characterized by comprising the following steps: taking blood samples to be detected, mixing the blood samples to be detected with a vitamin sample treatment solution, and detecting current signals generated when the blood samples are subjected to oxidation reduction reaction on a sensor probe of a vitamin detector by using the normal pulse stripping method; and making a standard curve through comparing the current signal values of standard samples with different vitamin concentrations, then obtaining the content of the vitamin in the blood samples to be detected according to the current signal values generated by the samples to be detected. The method provided by the invention has the advantages of high sensitivity, good accuracy, simplicity and convenience in operation, quickness, wide application range, suitability for being used in medical and health departments so as to carry out analysis and detection on vitamins A, B1, B2, B6, B9, B12, C, D, E, K1 and K3 in blood samples, and the like; and the method can be used for rapidly detecting the content of the vitamin in the blood samples.

The invention discloses a multi-gene detection kit for anti-epileptic drug medication guidance and a use method thereof. A multi-PCR and fragment length / mass analysis method is used for synchronously,quickly and quantitatively detecting eight single nucleotide polymorphism (SNP) loci on four genes, including CYP2C9, CYP2C19, POLG and UGT1A4, related to anti-epileptic drug metabolism, transfer andtarget site actions. Detection includes the steps that 1, oral cast-off cells are collected and stored in a cell acquisition card or a blood sample is collected and nucleic acid is extracted; 2, thecell acquisition card or the nucleic acid in step 1 serves as a template for multi-PCR amplification; 3, according to the length / mass of PCR product fragments, the eight SNP loci, three personal genome DNA reference (huDNA) genes and a PCR product of a PCR reaction internal reference are synchronously separated; 4, results are subjected to analysis and interpretation. The kit has the advantages ofbeing quick to use, high in sensitivity, good in repeatability, high in specificity, high in flux and low in cost.

A patient's skin puncturing device, particularly for collecting a blood sample for diagnostic purposes, comprises a housing (1), a lancet slidably positioned inside the housing (1) and having a body (3) with a sheathed puncturing needle (4) seated therein, and a push button (2) positioned at the one end of the housing (1). Between a face end of the push button (2) and the lancet body (3) a drive spring (5) is placed, and between the other end of the housing (1), which is provided with an opening (Ia) for the puncturing needle (4), and the lancet body (3) a return spring (7) is placed. Between the housing (1) and the lancet body (3) is placed lancet actuation locking means, preferably in the form of interlocks (6b) of a washer (6). The device has drive spring catching means, preferably in the form of grabs (6a) of the washer (6), to preclude the drive spring (5) from following the lancet in the puncture phase and in the retraction phase of the lancet.

The invention discloses a multiple gene detection kit for guiding antipsychotic drugs and a using method thereof. The kit adopts multiple PCR combined with a fragment length / mass analysis method and synchronously and qualitatively detects 7 nucleotide polymorphism (SNP) locus on 6 genes including CYP2D6, MC4R, CYP1A2, CYP3A5, EPM2A, and SLC6A2 which are related to antipsychotic drug metabolism, transport and target action. The method comprises the detection steps of (1) collecting oral exfoliated cells and storing on a cell collection card or collecting blood samples and extracting nucleic acids; (2) performing multiple PCR amplification using the cell collection card or nucleic acid as described in step 1 as formwork; (3) according to PCR product fragment length / mass, simultaneously separating into 7 SNP loci, 3 human DNA internal reference genes and 1 PCR reaction internal reference PCR product; (4) analyzing results and interpreting. The kit has the advantages of fast performance, high sensitivity, good repeatability, strong specificity, high throughput and low cost.

The invention discloses a sample analyzer. The sample analyzer comprises a sampling unit used for collecting a blood sample, a blood distribution valve adjacent to the sampling unit and used for carrying out quantitative separation and simultaneous distribution on the blood sample collected by the sampling unit, a reaction unit used for making the blood sample distributed by the blood distributionvalve into a test solution and comprising a plurality of reaction tanks connected with the blood distribution valve and positioned above the blood distribution valve, a detection unit adjacent to thereaction unit and comprising a plurality of detection parts used for detecting the test solution generated by the reaction unit to form detection information, a reagent unit used for providing a reagent required by each unit of the sample analyzer, and a gas path unit used for providing a positive pressure and a negative pressure for the sample analyzer. The invention further relates to a sampleanalysis method. The sample analyzer is reasonable in layout and accurate and rapid in measurement.

A hand-held analyzer for collecting a sample of blood from the scalp of a fetus and measuring the pH or other blood characteristic of the blood sample. The analyzer includes a probe with a proximal end and a gasket that facilitate a firm and positive placement of the probe against the scalp. The probe includes a capillary tube for collecting blood and an extensible lancet which at rest is positioned within the capillary tube. During operation, the lancet is extended to make an incision in the scalp. The lancet then retreats, and blood flows into the capillary tube. Sensors for measuring pH are in liquid communication with the capillary tube. A display on or near the hand-held analyzer shows a readout of the fetal scalp blood pH or other blood characteristic. Measuring the pH of the fetal scalp blood in utero can provide early detection of acidosis and likely hypoxia.

The invention discloses a multi-gene detection kit for anti-depression drug medication guidance and a using method of the kit. A multi-PCR and fragment length / mass analysis method is used for synchronously, quickly and quantitatively detecting seven single nucleotide polymorphism (SNP) loci on four genes, including CYP2D6, CYP2C19, ABCB1 and FKBP5, related to anti-depression drug metabolism, transfer and target site actions. Detection includes the steps that 1, oral cast-off cells are collected and stored in a cell acquisition card or a blood sample is collected and nucleic acid is extracted;2, the cell acquisition card or the nucleic acid in step 1 serves as a template for multi-PCR amplification; 3, according to the length / mass of PCR product fragments, the seven SNP loci, three human DNA referenc genes and a PCR product of a PCR reaction internal reference are synchronously separated; 4, results are subjected to analysis and interpretation. The kit has the advantages of being quickto use, high in sensitivity, good in repeatability, high in specificity, high in flux and low in cost.

The invention discloses a rapid panoramic stitching method for microscopic blood cell images. The method includes fixing a microscopic camera, enabling the mobile platform to continuously collect blood sample slides according to a bow-shaped route, obtaining microscopic blood cell image data, and performing filtering and denoising processing on the to-be-spliced image by using a Gaussian operator;extracting image feature points by using an SURF feature method; performing feature matching by using an FLANN method, performing comparison with a set value, removing duplicate images, and obtainingcoarse matching results; solving a coordinate transformation homography matrix of the to-be-spliced image and the spliced image by adopting a random sampling consistency method; using a random sampling consistency method again to obtain accurate matching point pairs; calculating the position relationship between the image A and the image B according to the accurate matching point pairs, completing the unification of coordinates, carrying out the fusion transition of the overlapping region, completing the stitching, traversing all blood sample slides, sequentially carrying out the stitching calculation, and outputting a panoramic blood cell image, thereby improving the stitching quality and speed.

A lancing device is adapted for use in firing a lancet into the skin of a patient to acquire a blood sample and, subsequent thereto, calculating and displaying the concentration of glucose in the acquired sample. In one embodiment, the device comprises a lancet and a torsion spring coupled to the lancet through a lancet holder. The torsion spring includes inner, middle and outer rings which are concentrically configured, a plurality of activation spring arms which connect the middle and outer rings and a plurality of return spring arms which connect the inner and middle rings. In use, the plurality of activation and return spring arms can be independently transformed between energized and de-energized states using a single, button-shaped mechanism. Rotation of the mechanism is used to energize the activation and return spring arms. With the return spring arms maintained in their energized state, depression of the mechanism transforms the activation spring arms from their energized state to their de-energized state which drives the lancet from a retracted position to an extended position. Once the activation spring arms reach their de-energized state, the return spring arms transform from their energized state to their de-energized state which pulls the lancet back from its extended position to its retracted position.

The invention provides a blood cell analyzer and a cleaning method thereof. The blood cell analyzer comprises a mode setting module used for setting a working mode of the blood cell analyzer; a sampling distribution module, which is used for collecting blood samples and distributing the blood samples to the erythrocyte sedimentation rate detection module and / or the blood routine examination module; an erythrocyte sedimentation rate detection module, which is used for detecting the erythrocyte sedimentation rate of the blood sample; a blood routine detection module, which is used for performing blood routine detection on the blood sample; a liquid path supporting module, which is at least used for cleaning the sampling distribution module; a control device, which is at least used for controlling at least one of the erythrocyte sedimentation rate detection module and the blood routine detection module to operate according to a set working mode; besides, the blood cell analyzer is further provided with different cleaning modes, and the control device is further used for controlling the liquid path supporting module to execute the corresponding cleaning mode according to the set working mode so as to clean the sampling distribution module. According to the scheme, the testing speed can be increased, and the cleaning liquid consumption is reduced.

The invention discloses a multiple gene detection kit used for medication guidance of an anti-manic medicine and a use method thereof. According to the multiple gene detection kit used for medicationguidance of the anti-manic medicine and the use method thereof, multiple PCR in combination with a fragment length / quality analysis method is adopted, so that two single nucleotide polymorphism (SNP)sites on GSK3B and NTRK2 genes which are related to medication of the anti-manic medicine are detected synchronously, fast and qualitatively. The use method of the multiple gene detection kit used formedication guidance of the anti-manic medicine comprises the detection steps of (1) collecting oral cavity exfoliative cells, and storing the oral cavity exfoliative cells in a cell collection card or collecting a blood sample, and extracting nucleic acid; (2) adopting the cell collection card or the nucleic acid in the step (1) as a template for multiple PCR amplification; (3) according to PCR product fragment length / quality, separating the two SNP sites, three human genome DNA reference genes and a PCR reaction reference PCR product synchronously; and (4) analyzing and judging results. Themultiple gene detection kit used for medication guidance of the anti-manic medicine has the advantages of being fast, high in sensibility, good in repeatability, high in specificity, high in flux andlow in cost.

The invention discloses a multi-stage inertial micro-fluidic blood sample processing chip integrating a micro-mixer and a Tesla valve, relates to an integrated implementation method of rapid volume expansion and target cell screening of a micro-collected blood sample, and particularly relates to integrated design and preparation of the micro-mixer, a two-stage inertial cell sorting unit and a Tesla valve flow resistance matching unit. According to the invention, series connection of two stages of inertial micro-fluidic units is realized by utilizing a flow resistance matching method, and high-precision enrichment and screening of rare cancer cells in a trace blood sample are realized by combining export of blood cells through a flow resistance matching flow channel with two-stage inertial focusing, and compared with the existing one-stage passive micro-fluidic cancer cell screening technology, the two-stage series scheme provided by the invention is higher in screening purity. According to an existing micro-fluidic cell manipulation technology, a blood sample needs to be diluted firstly and then injected into a micro-fluidic chip, and according to the micro-fluidic cell manipulation technology, the micro-mixer and inertial cancer cell screeners (a first-stage inertial sorting unit and a second-stage inertial sorting unit) are integrated on an integrated sheet, so that dilution of the micro blood sample and high-precision screening of cancer cells are achieved.

A process for the production of a tubular holder for vacuum test tubes and the holder obtained therefrom. The process includes the steps of inserting a straight needle into the holder and the subsequent bending of the needle, so that the outer end of the needle is first connected to the edge of a slanted support wall extending from the casing and has a terminal portion aligned with a side wall of the casing, thus facilitating the insertion of the needle into the limb of a patient. The new disposable holder is particularly useful for blood sampling because it provides for the alignment of the needle with respect to the patient's vein.