The invention provides a major loop electric power cable for a medium-voltage frequency converter. The cable comprises three power conductors, three control conductors and a central gap filler, wherein the cross section of the central gap filler is round, a cabled core is formed by stranding of the three power conductors and the three control conductors around the central gap filler, the control conductors are arranged between any two adjacent power conductors, the cabled core is sequentially coated with a third metal shielding layer, an electrostatic shielding layer, a water-blocking tape covering layer, a tin-plated steel wire winding armor layer and a polyolefin outer sheath, and water-blocking ropes with triangular cross sections are placed in gaps between the power conductors, the control conductors and the third metal shielding layer. According to the major loop electric power cable for the medium-voltage frequency converter, effective capacitance is low, transfer impedance is low, good electromagnetic compatibility is achievable, the tensile strength and water resistance of the cable are improved, and the service life of the cable is prolonged.