The invention provides a comprehensive pipe gallery information pre-warning system and method. The system comprises a strain sensor, a stress sensor, an earth pressure cell, a reinforcement stress gauge, a water pressure sensor, a water level indicator and a computer. A foundation soil layer pre-warning unit, a pipe gallery cushion layer pre-warning unit and a pipe gallery lining structure pre-warning unit are arranged in the computer. According to the comprehensive pipe gallery information pre-warning system and method, informatization of the construction process of a comprehensive pipe gallery is facilitated, and a three-dimensional information model of the comprehensive pipe gallery is established through parametrization design software. The comprehensive pipe gallery information pre-warning system and method have the characteristics of convenient modification, three-dimension visualization and accurate outputting of a construction drawing of the municipal comprehensive pipe gallery. In addition, the comprehensive pipe gallery information pre-warning system and method have an engineering anticipation warning function and can monitor all indicators of the comprehensive pipe gallery in the construction process and give pre-warning in real time through application in engineering, and thus constructors can adjust construction conveniently in time. Construction can be constructed by designers reasonably, drawing inspecting work is reduced, reworking and design change are reduced, site accurate construction is achieved, head room of the underground pipe gallery is ensured, and inspection and maintenance of the comprehensive pipe gallery during usage are facilitated.