The invention discloses a safety box avoiding infant accidental touching. The safety box comprises a box body and a cover body which is provided with an opening in one end. Two sides of the box body are provided with through holes I. The lateral side of the cover body is provided with a through hole II. A connecting piece is arranged between the box body and the cover body, above the cover body and along the edge of the upper portion of the cover body and provided with a groove, a protrusion I and an adjusting device, wherein the groove is matched with the thickness of the cover body; the protrusion I is matched with the inner side of the box body; the adjusting device is used for adjusting the opening or closing of the cover body and comprises buttons and a protrusion II, the buttons arematched with the through hole I, the protrusion II is integrally formed, arranged above the buttons and matched with the through hole II, and the protrusion II, the buttons and the connecting piece are movably connected. When the buttons at the two ends of the box body are pressed, the protrusion II caves in along with the buttons, and the cover body slides to open the safety box, so that the connecting structure is stable, injuries, generated when an infant accidentally touches dangerous articles, to the infant are effectively avoided, the practicability is strong, and the safety box can be widely applied to the technical field of boxes.