77results about How to "Reduced dose rate" patented technology

The present invention relates to the intrathecal (IT) administration of recombinant enzyme to treat lysosomal storage disorders. In an exemplary embodiment, intrathecal administration of human α-L-iduronidase (rhIDU) injections in MPS I affected animals resulted in significant enzyme uptake, significant rh-iduronidase activity in brain and meninges and a decrease of glycosaminoglycan (GAG) storage in cells of MPS I subjects to that of normal subjects. Intrathecal administration proved more effective than intravenous treatment at alleviating MPS I symptoms, indicating it is a useful method of treating lysosomal storage disorders.

A method and system for reducing stress corrosion cracking in a hot water system, such as a nuclear reactor, by reducing the electrochemical corrosion potential of components exposed to high temperature water within the structure. The method includes the steps of: providing a reducing species to the high temperature water; and providing a plurality of noble metal nanoparticles having a mean particle size of up to about 100 nm to the high temperature water during operation of the hot water system. The catalytic nanoparticles, which may contain at least one noble metal, form a colloidal suspension in the high temperature water and provide a catalytic surface on which a reducing species reacts with least one oxidizing species present in the high temperature water. The concentration of the oxidizing species is reduced by reaction with the reducing species on the catalytic surface, thereby reducing the electrochemical corrosion potential of the component.

A process to reduce or prevent biofouling, by destroying or deactivating microbiological content of feedwater, or other liquid, prior to its entrance into membranes or process equipment, such as heat transfer equipment. The process comprises the use of electrical discharge and / or electric fields to destroy microbes that result in the biofouling of surfaces. By destroying the microbiological content of the water the microbiology no longer is able to create a restricting biofilm upon or within said process equipment.

A radiotherapeutic apparatus comprises a source able to emit a beam of therapeutic radiation along a beam axis, a multi-leaf collimator arranged to collimate the beam to a desired shape, wherein the source is rotatable about a rotation axis that is substantially orthogonal and intersects with the beam axis thereby to describe an arc around that axis, and further comprises a control means able to control the dose / time rate of the source, the rotation speed of the source, and the multi-leaf collimator position. The control means is arranged to control the source in accordance with a treatment plan over first and second arc-segments such that at least the multi-leaf collimator changes shape at a different rate per degree in the second arc-segment as to the first arc-segment.

A radiotherapeutic apparatus comprises a source able to emit a beam of therapeutic radiation along a beam axis, a multi-leaf collimator arranged to collimate the beam to a desired shape, wherein the source is rotateable about a rotation axis that is substantially orthogonal and intersects with the beam axis thereby to describe an arc around that axis, and further comprises a control means able to control the dose / time rate of the source, the rotation speed of the source, and the multi-leaf collimator position. The control means is arranged to receive a treatment plan in which the arc is divided into a plurality of notional arc-segments, and specifying the total dose for the arc-segment and a start and end MLC position. It then controls the source in accordance with that plan over an first arc-segment such that at least one of the rotation speed and dose rate are constant and the multi-leaf collimator changes shape, and a second arc segment such that at least one of the rotation speed and dose rate are constant at a level different to the constant level adopted during the first arc-segment. It achieves this by calculating the total time required for the arc segment for a plurality of factors including an MLC leaf movement from a prescribed position at the start of the arc-segment to a prescribed position at the end of the arc-segment, at a maximum leaf speed, rotation of the source from the start to the end of the arc-segment at a maximum source rotation speed, delivery of the dose at a maximum dose rate per time, selecting the factor dictating the longest time, and controlling the apparatus so that the selected factor operates at its respective maximum and the remaining factors are operated at a reduced rate selected to match that longest time.

A method for treating a subterranean formation penetrated by a wellbore, the method including the introduction of a well treatment fluid containing at least an encapsulated biocide. Once the encapsulated biocide is introduced and after a predetermined period of time, a biocide is released from an encapsulation material and treats the wellbore and the subterranean formation.

A clay stabilizer which is capable of inhibiting swelling in a wide variety of clay types and is also capable of restoring permeability in formations which have previously been damaged by clay swelling. Amine salts of differing molecular weights configurations and ionic strength are combined to provide transport into micropores, mesopores and macropores in the formation and to effect cationic change therein. A poly quaternary amine having a high to very high charge density is added along with lower molecular weight amine salts to substantially permanently exchange cations with the clay in the formation.

Exemplary compositions and methods for reducing hexavalent chromium in cementitious compositions involve the use of a liquid additive composition, comprising stannous chloride. Along with the stannous chloride may be used at least one co-additive comprising an antioxidant, oxygen scavenger, or mixture thereof, and / or at least one agent comprising a cement grinding aid, cement quality improver, or mixture thereof.

The present invention relates to stable glyphosate formulations with improved efficacy by a highly effective alkoxylated alkylamine quaternary surfactant at a very low used level. The alkoxylated alkylamine quaternary surfactant is compatible in all salts of glyphosate formulations (including potassium and ammonium) EVEN AT VERY HIGH CONCENTRATION (470-600 g a.e. / l).

The present invention is a method and system for developing a dynamic scheme for Gamma Knife radiosurgery based on the concept of “dose-painting” to take advantage of robotic patient positioning systems on the Gamma Knife C and Perfexion units. The spherical high dose volume created by the Gamma Knife unit will be viewed as a 3D spherical “paintbrush”, and treatment planning is reduced to finding the best route of this “paintbrush” to “paint” a 3D tumor volume. Under the dose-painting concept, Gamma Knife radiosurgery becomes dynamic, where the patient is moving continuously under the robotic positioning system.

Apparatus comprising a radiation source which can rotate in an arc around the radiation beam axis, a multi-leaf collimator (MLC), and a controller for the source dose / time rate, the source rotation speed, and the MLC position. The controller calculates the time required for (i) an MLC leaf movement from start to end of an arc-segment at a maximum leaf speed, (ii) rotation of the source from start to end of the arc-segment at a maximum speed, and (iii) delivery of the dose at a maximum dose rate per time, selects the longest of (i), (ii) and (iii), and operates the selected one at its maximum and the others at a reduced rate matching that longest time, the time required for (i) and / or (ii) being the greater of the time to complete the segment at a continuous speed and the time to accelerate the item to that speed.

Described herein are Tz / TCO-based pretargeting strategies using an Al[18F]-NOTA-labeled tetrazine radioligand. This imaging strategy enables delineation of cancer at earlier time points compared to other imaging strategies and further decreases the radiation dose to healthy tissues compared to directly labeled antibodies. Al-based 18F imaging of small molecules, such as tetrazine, has not been previously achieved due to the decomposition of tetrazine during radiofluorination. Radiofluorination is advantageous over other radiolabeling methods because, in addition to having a shorter half-life, 18F is more readily available to produce and therefore integrated into hospital workflows.

Exemplary compositions and methods for reducing hexavalent chromium in cementitious compositions involve the use of a liquid additive composition, comprising stannous chloride. Along with the stannous chloride may be used at least one co-additive comprising an antioxidant, oxygen scavenger, or mixture thereof, and / or at least one agent comprising a cement grinding aid, cement quality improver, or mixture thereof.

A remmeter includes two or more different-sized hydrogenous moderators, each incorporating a hydrogenous spectroscopic fast neutron detector and a thermal neutron detector to provide more accurate neutron dosimetry across a wide range of neutron energies (thermal neutrons to >15 MeV) in a form factor that is lighter than conventional remmeters. The remmeter utilizes the principle of spectral dosimetry, where the energy or energy distribution of the incident neutrons is first measured and then this energy information (along with the measured fluence) is used to establish the dosimetric quantity using the various fluence-to-dose conversion curves (e.g. H*(10) (ICRP(1997)), NCRP-38(1971)). Using the method of spectral dosimetry, the large variation in response in these curves as a function of neutron energy (especially over the region 1 keV to 1 MeV) is largely mitigated through the use of the energy and fluence information, and the appropriate fluence-to-dose conversion curve to calculate the dose.

An expansion gap radiation shield is formed from a flexible container housing a radiation shielding fluid, that is located within a variable gap in permanent shielding. The invention reduces radiation dose rates outside the gap when the radiation sources are located on the opposite side of the gap. The device accommodates varying gap sizes with no loss of shielding capability.

The present invention relates to stable glyphosate formulations with improved efficacy by a highly effective alkoxylated alkylamine quaternary surfactant at a very low used level. The alkoxylated alkylamine quaternary surfactant is compatible in all salts of glyphosate formulations (including potassium and ammonium) EVEN AT VERY HIGH CONCENTRATION (470-600 g a.e. / l).

The present invention comprises a refueling work platform for use during reactor refueling operation to allow inspection / repair of the reactor vessel simultaneously with the removal and insertion of fuel cells from and into the reactor due to the personnel ring of the work platform being movable down into the reactor cavity to allow a refueling platform to move over the work platform to provide refueling operations while the personnel on the ring are doing their inspection and repair.

The present invention relates to a pesticidal composition comprising pyrifluquinazon and lambda-cyhalothrin, and specifically relates to a method for controlling pests. The pesticidal composition comprising pyrifluquinazon and lambda-cyhalothrin has a weight ratio of pyrifluquinazon to lambda-cyhalothrin of 1:100 to 100:1. A method for preventing or controlling pests: using the pesticidal composition on a target useful plant, a target pest or an environment thereof, and a reproductive material for the target useful plant. A method for protecting plant seeds comprising: allowing seeds to be in contact with an efficacious dose of the pesticidal composition of the present invention before sowing and / or after germination. A seed administered and treated with an efficacious dose of the pesticidal composition of the present invention.