77results about How to "Reduced dose rate" patented technology

The present invention relates to the intrathecal (IT) administration of recombinant enzyme to treat lysosomal storage disorders. In an exemplary embodiment, intrathecal administration of human α-L-iduronidase (rhIDU) injections in MPS I affected animals resulted in significant enzyme uptake, significant rh-iduronidase activity in brain and meninges and a decrease of glycosaminoglycan (GAG) storage in cells of MPS I subjects to that of normal subjects. Intrathecal administration proved more effective than intravenous treatment at alleviating MPS I symptoms, indicating it is a useful method of treating lysosomal storage disorders.

The present invention relates to the intrathecal (IT) administration of recombinant enzyme to treat lysosomal storage disorders. In an exemplary embodiment, intrathecal administration of human α-L-iduronidase (rhIDU) injections in MPS I affected animals resulted in significant enzyme uptake, significant rh-iduronidase activity in brain and meninges and a decrease of glycosaminoglycan (GAG) storage in cells of MPS I subjects to that of normal subjects. Intrathecal administration proved more effective than intravenous treatment at alleviating MPS I symptoms, indicating it is a useful method of treating lysosomal storage disorders.

PCT No. PCT / EP97 / 06574 Sec. 371 Date Jun. 6, 1999 Sec. 102(e) Date Jun. 6, 1999 PCT Filed Nov. 25, 1997 PCT Pub. No. WO98 / 24496 PCT Pub. Date Jun. 11, 1998A medicament dosing system comprises a replaceable unit and a permanent unit. The replaceable unit comprises a fluid reservoir for receiving therein a pressurizable liquid medicament, a temperature sensor for detecting the temperature of said liquid medicament, a fluid channel which is provided with a flow resistor and which is in flow communication with the fluid reservoir, and a hose means which is connected to the fluid channel. The permanent unit comprises a squeezing valve means for squeezing the hose means together, and a control means which is coupled to the temperature sensor and the squeezing valve means so as to control a flow rate of the liquid medicament by clocked actuation of said squeezing valve means depending on the temperature detected. Alternatively, the temperatur sensor can be arranged in the permanent unit.

A clay stabilizer which is capable of inhibiting swelling in a wide variety of clay types and is also capable of restoring permeability in formations which have previously been damaged by clay swelling. Amine salts of differing molecular weights configurations and ionic strength are combined to provide transport into micropores, mesopores and macropores in the formation and to effect cationic change therein. A poly quaternary amine having a high to very high charge density is added along with lower molecular weight amine salts to substantially permanently exchange cations with the clay in the formation.

A method and system for reducing stress corrosion cracking in a hot water system, such as a nuclear reactor, by reducing the electrochemical corrosion potential of components exposed to high temperature water within the structure. The method includes the steps of: providing a reducing species to the high temperature water; and providing a plurality of noble metal nanoparticles having a mean particle size of up to about 100 nm to the high temperature water during operation of the hot water system. The catalytic nanoparticles, which may contain at least one noble metal, form a colloidal suspension in the high temperature water and provide a catalytic surface on which a reducing species reacts with least one oxidizing species present in the high temperature water. The concentration of the oxidizing species is reduced by reaction with the reducing species on the catalytic surface, thereby reducing the electrochemical corrosion potential of the component.

Exemplary compositions and methods for reducing hexavalent chromium in cementitious compositions involve the use of a liquid additive composition, comprising stannous chloride. Along with the stannous chloride may be used at least one co-additive comprising an antioxidant, oxygen scavenger, or mixture thereof, and / or at least one agent comprising a cement grinding aid, cement quality improver, or mixture thereof.

A process to reduce or prevent biofouling, by destroying or deactivating microbiological content of feedwater, or other liquid, prior to its entrance into membranes or process equipment, such as heat transfer equipment. The process comprises the use of electrical discharge and / or electric fields to destroy microbes that result in the biofouling of surfaces. By destroying the microbiological content of the water the microbiology no longer is able to create a restricting biofilm upon or within said process equipment.

A radiotherapeutic apparatus comprises a source able to emit a beam of therapeutic radiation along a beam axis, a multi-leaf collimator arranged to collimate the beam to a desired shape, wherein the source is rotatable about a rotation axis that is substantially orthogonal and intersects with the beam axis thereby to describe an arc around that axis, and further comprises a control means able to control the dose / time rate of the source, the rotation speed of the source, and the multi-leaf collimator position. The control means is arranged to control the source in accordance with a treatment plan over first and second arc-segments such that at least the multi-leaf collimator changes shape at a different rate per degree in the second arc-segment as to the first arc-segment.

The invention relates to the field of nuclear radiation screening and protecting, and particularly relates to a high-temperature resisting shielding material with a neutron shielding effect, which is used for screening and protection of neutron radioactive sources such as isotopic neutron source, nuclear reactors, accelerators and the like. The material comprises the following components parts by weight: 40 to 50 parts of basis material, 40 to 50 parts of curing agent, 5 to 10 parts of wild phase particles, and 1 to 5 parts of modified particles. The material has a strong irradiation resisting performance, has a strong mechanical property, is used for screening and protecting to neutron radiation, and can bear the high temperature which is more than 200 DEG C.

A radiotherapeutic apparatus comprises a source able to emit a beam of therapeutic radiation along a beam axis, a multi-leaf collimator arranged to collimate the beam to a desired shape, wherein the source is rotateable about a rotation axis that is substantially orthogonal and intersects with the beam axis thereby to describe an arc around that axis, and further comprises a control means able to control the dose / time rate of the source, the rotation speed of the source, and the multi-leaf collimator position. The control means is arranged to receive a treatment plan in which the arc is divided into a plurality of notional arc-segments, and specifying the total dose for the arc-segment and a start and end MLC position. It then controls the source in accordance with that plan over an first arc-segment such that at least one of the rotation speed and dose rate are constant and the multi-leaf collimator changes shape, and a second arc segment such that at least one of the rotation speed and dose rate are constant at a level different to the constant level adopted during the first arc-segment. It achieves this by calculating the total time required for the arc segment for a plurality of factors including an MLC leaf movement from a prescribed position at the start of the arc-segment to a prescribed position at the end of the arc-segment, at a maximum leaf speed, rotation of the source from the start to the end of the arc-segment at a maximum source rotation speed, delivery of the dose at a maximum dose rate per time, selecting the factor dictating the longest time, and controlling the apparatus so that the selected factor operates at its respective maximum and the remaining factors are operated at a reduced rate selected to match that longest time.

Exemplary compositions and methods for reducing hexavalent chromium in cementitious compositions involve the use of a liquid additive composition, comprising stannous chloride. Along with the stannous chloride may be used at least one co-additive comprising an antioxidant, oxygen scavenger, or mixture thereof, and / or at least one agent comprising a cement grinding aid, cement quality improver, or mixture thereof.

The invention discloses a total dose irradiation test method for an MCM / HIC circuit based on low-energy X-ray. The method comprises the following steps: firstly analyzing the MCM / HIC circuit to determine irradiation sensitive components in the MCM / HIC circuit, then irradiating one or a plurality of sensitive components by an irradiation fixture in the operating state of the MCM / HIC circuit to determine the radiation resistance of the sensitive components in the operating state of the circuit, and finally performing total dose irradiation on the whole MCM / HIC circuit and testing electrical parameters of the MCM / HIC circuit in an on-line monitoring manner. The technology of the invention can be used for achieving anti-radiation total dose level test evaluation on a multi-chip hybrid integrated circuit, thus evaluating the radiation resistance of the whole circuit, and studying the radiation resistance of the sensitive components in the circuit, which is good for the partial anti-radiation reinforcement design of a circuit.

A clay stabilizer which is capable of inhibiting swelling in a wide variety of clay types and is also capable of restoring permeability in formations which have previously been damaged by clay swelling. Amine salts of differing molecular weights configurations and ionic strength are combined to provide transport into micropores, mesopores and macropores in the formation and to effect cationic change therein. A poly quaternary amine having a high to very high charge density is added along with lower molecular weight amine salts to substantially permanently exchange cations with the clay in the formation.

Exemplary compositions and methods for reducing hexavalent chromium in cementitious compositions involve the use of a liquid additive composition, comprising stannous chloride. Along with the stannous chloride may be used at least one co-additive comprising an antioxidant, oxygen scavenger, or mixture thereof, and / or at least one agent comprising a cement grinding aid, cement quality improver, or mixture thereof.

The present invention relates to stable glyphosate formulations with improved efficacy by a highly effective alkoxylated alkylamine quaternary surfactant at a very low used level. The alkoxylated alkylamine quaternary surfactant is compatible in all salts of glyphosate formulations (including potassium and ammonium) EVEN AT VERY HIGH CONCENTRATION (470-600 g a.e. / l).

The present invention is a method and system for developing a dynamic scheme for Gamma Knife radiosurgery based on the concept of “dose-painting” to take advantage of robotic patient positioning systems on the Gamma Knife C and Perfexion units. The spherical high dose volume created by the Gamma Knife unit will be viewed as a 3D spherical “paintbrush”, and treatment planning is reduced to finding the best route of this “paintbrush” to “paint” a 3D tumor volume. Under the dose-painting concept, Gamma Knife radiosurgery becomes dynamic, where the patient is moving continuously under the robotic positioning system.

A pre-computed importance function providing ex ante assessment of optimal placement of a single radioactive source is used for sequential placement of multiple radioactive sources. As each source is placed, the importance function may be modified to reflect the dose implemented by that source and all sources already placed. The greedy algorithm employed by this technique makes possible optimization of additional dimensions of treatment planning including, using directional and isotropic sources, using different source isotopes, using optimum source strengths, using source locations that are not on the regular grid and using a single movable source for variable times at different locations.

Described herein are Tz / TCO-based pretargeting strategies using an Al[18F]-NOTA-labeled tetrazine radioligand. This imaging strategy enables delineation of cancer at earlier time points compared to other imaging strategies and further decreases the radiation dose to healthy tissues compared to directly labeled antibodies. Al-based 18F imaging of small molecules, such as tetrazine, has not been previously achieved due to the decomposition of tetrazine during radiofluorination. Radiofluorination is advantageous over other radiolabeling methods because, in addition to having a shorter half-life, 18F is more readily available to produce and therefore integrated into hospital workflows.

Exemplary compositions and methods for reducing hexavalent chromium in cementitious compositions involve the use of a liquid additive composition, comprising stannous chloride. Along with the stannous chloride may be used at least one co-additive comprising an antioxidant, oxygen scavenger, or mixture thereof, and / or at least one agent comprising a cement grinding aid, cement quality improver, or mixture thereof.

A remmeter includes two or more different-sized hydrogenous moderators, each incorporating a hydrogenous spectroscopic fast neutron detector and a thermal neutron detector to provide more accurate neutron dosimetry across a wide range of neutron energies (thermal neutrons to >15 MeV) in a form factor that is lighter than conventional remmeters. The remmeter utilizes the principle of spectral dosimetry, where the energy or energy distribution of the incident neutrons is first measured and then this energy information (along with the measured fluence) is used to establish the dosimetric quantity using the various fluence-to-dose conversion curves (e.g. H*(10) (ICRP(1997)), NCRP-38(1971)). Using the method of spectral dosimetry, the large variation in response in these curves as a function of neutron energy (especially over the region 1 keV to 1 MeV) is largely mitigated through the use of the energy and fluence information, and the appropriate fluence-to-dose conversion curve to calculate the dose.

An expansion gap radiation shield is formed from a flexible container housing a radiation shielding fluid, that is located within a variable gap in permanent shielding. The invention reduces radiation dose rates outside the gap when the radiation sources are located on the opposite side of the gap. The device accommodates varying gap sizes with no loss of shielding capability.

A method of forming bipolar junction devices, including forming a mask to expose the total surface of the emitter region and adjoining portions of the surface of the base region. A first dielectric layer is formed over the exposed surfaces. A field plate layer is formed on the first dielectric layer juxtaposed on at least the total surface of the emitter region and adjoining portions of the surface of the base region. A portion of the field plate layer is removed to expose a first portion of the emitter surface. A second dielectric layer is formed over the field plate layer and the exposed portion of the emitter. A portion of the second dielectric layer is removed to expose the first portion of the emitter surface and adjoining portions of the field plate layer. A common contact is made to the exposed first portion of the emitter surface and the adjoining portions of the field plate layer. In another embodiment, the field plate and emitter contact are formed simultaneously.

The ion exchange resin processing device (10) has a tank (12) for receiving an aqueous ion exchange resin suspension (14). A stirring device (16) is provided in tank for stirring. A grinder (20) e.g. colloid mill is provided outside the tank. A pumping device (22) is provided for feeding the aqueous ion exchange resin suspension from tank to grinder. The grinding surface of colloid mill is made from metal, metal carbide or ceramic. An independent claim is included for ion exchange resin processing method.

The present invention relates to stable glyphosate formulations with improved efficacy by a highly effective alkoxylated alkylamine quaternary surfactant at a very low used level. The alkoxylated alkylamine quaternary surfactant is compatible in all salts of glyphosate formulations (including potassium and ammonium) EVEN AT VERY HIGH CONCENTRATION (470-600 g a.e. / l).

The invention provides an aqueous dispersion composition containing abamectin and acetamiprid. The aqueous dispersion composition comprises 1%-80% of abamectin and acetamiprid serving as effective components, 1%-50% of at least one of ammonium sulfate, ammonium nitrate, ammonium hydrogen phosphate, ammonium dihydrogen phosphate and ammonium carbonate and one or more other preparation component. The sum of all components in the composition is 100% by weight. The composition further comprises at least one penetrating agent. The granularity of the composition ranges from 0.1 micrometer to 3.6 micrometers, and the composition is used for preventing or controlling pests.

The present invention comprises a refueling work platform for use during reactor refueling operation to allow inspection / repair of the reactor vessel simultaneously with the removal and insertion of fuel cells from and into the reactor due to the personnel ring of the work platform being movable down into the reactor cavity to allow a refueling platform to move over the work platform to provide refueling operations while the personnel on the ring are doing their inspection and repair.

The present invention relates to a pesticidal composition comprising pyrifluquinazon and lambda-cyhalothrin, and specifically relates to a method for controlling pests. The pesticidal composition comprising pyrifluquinazon and lambda-cyhalothrin has a weight ratio of pyrifluquinazon to lambda-cyhalothrin of 1:100 to 100:1. A method for preventing or controlling pests: using the pesticidal composition on a target useful plant, a target pest or an environment thereof, and a reproductive material for the target useful plant. A method for protecting plant seeds comprising: allowing seeds to be in contact with an efficacious dose of the pesticidal composition of the present invention before sowing and / or after germination. A seed administered and treated with an efficacious dose of the pesticidal composition of the present invention.

A method for the cleanup of ionic species such as cobalt and nickel in nuclear power plant aqueous streams using a sequestration resin material is disclosed herein. The method includes the steps of providing a sequestration resin for removal of radioisotopes of transition metal impurities contained in the plant process streams, and distributing the sequestration resin into the plant process streams such that the sequestration resin interacts with the process streams and removes the transition metal impurities.