The invention discloses an automobile rollover prevention control device and method based on slight sideslip. The device comprises first to fourth force sensors, a vehicle speed sensor, a CCD camera,a longitudinal acceleration sensor, a lateral acceleration sensor, a yaw rate sensor, first to fourth electromagnetic valve spray heads, a hydraulic pump, a water tank, a road surface adhesion estimator and a control unit. When an automobile runs in a curve on a high-adhesion road surface, the vertical force of four tires is detected by the force sensors, so that the lateral load transfer rate (LTR) is obtained. When the LTR value exceeds a threshold value, the liquid spraying time of a liquid spraying device is calculated according to the mapping relation of centrifugal force, lateral force and lateral acceleration, and the first to fourth electromagnetic valve spray heads are controlled to spray liquid to the four tires, so that the effects of reducing the road surface adhesion coefficient and generating small slippage are achieved. The device has the advantages of simple structure, clear principle and convenient use, effectively restrains the risk of rollover of the automobile on the road surface with a high adhesion coefficient, and improves the active safety of the automobile.