The application discloses a method for preparing a silk
fibroin and
hyaluronic acid composite gel, which comprises the following steps: uniformly mixing hyaluronate with a first
solvent to prepare a
hyaluronic acid gel, mixing the
hyaluronic acid gel with a silk
fibroin solution, high-speed shearing homogenization and emulsification, standing, high-speed shearing homogenization and emulsification, sealing, sterilization, and obtaining the composite gel. The method does not need to add additional cross-linking agents, initiators, enzymes and other reagents; during the homogenization and gel formation process, the silk
fibroin solution and the hyaluronic
acid gel can form a uniform mutual cross-linking
double network, the risk of phase separation is low, and high-speed homogenization can make the silk fibroin produce an emulsification reaction, so that the color of the composite gel is whiter; the preparation method is simple, fast emulsification and gel formation, the
production cycle is short, the product has low endotoxin, high
biocompatibility, slow degradation, small inflammatory reaction, high safety of injection and filling, and the composite gel can play a role in water replenishment and moisturization after
subcutaneous injection, has the effects of improving
skin elasticity and gloss, and lightening fine lines and other whitening effects.