The invention discloses a drainage frame for neurosurgery, which belongs to the technical field of drainage frames and comprises a base, a lifting mechanism, a supporting mechanism, a positioning seat, a clamping mechanism, a drainage bottle and an adjusting mechanism. By changing the vertical distance between the adjusting shaft and the moving shaft, the included angle between the adjusting plate and the positioning plate and the included angle between the adjusting plate and the push plate can be changed, namely the distance between the positioning plate and the push plate can be changed, so that a drainage bottle can be pushed to move, the purpose of fine adjustment of the drainage bottle is achieved, and the use purpose of different distances between the drainage bottle and a patient is achieved; when a drainage bottle is placed in the device, a clamping plate and a connecting plate can extrude a spring, the clamping stability of the drainage bottle can be guaranteed under the cooperation of the clamping plate, the connecting plate and the spring, and therefore the actual using effect can be guaranteed; and the lifting column is manually rotated to drive the movable plate to move in the fixed cylinder, so that the height adjustment of the supporting mechanism and components at the upper end of the supporting mechanism can be realized, the use requirements of different heights can be met, and the operation is simple.