A high-strength steel sheet with yield strength of 1100MPa and a manufacturing method thereof. The high-strength steel sheet comprises, based on the weight percentage, 0.15-0.25% of C, 0.10-0.50% of Si, 0.60-1.20% of Mn, no more than 0.013% of P, no more than 0.003% of S, 0.20-0.55% of Cr, 0.20-0.70% of Mo, 0.60-2% of Ni, 0-0.07% of Nb, 0-0.07% of V, 0.0006-0.0025% of B, 0.01-0.08% of Al, 0.003-0.06% of Ti, no more than 0.00018% of H, no more than 0.0040% of N, no more than 0.0030% of O, and the balance of Fe and inevitable impurities; and the carbon equivalent CEQ is no more than 0.60%. A quenching and a tempering heat treatment are employed to obtain a tempered martensite tissue. The steel provided by the present invention has yield strength no less than 1100MPa, tensile strength no less than 1250MPa, Charpy ballistic work Akv (-40 DEG C) no less than 50J, and good strength and toughness.