The invention provides an infiltration detection device for predicting or detecting preeclampsia. The device comprises an enclosed shell, which is formed by an upper cover and a bottom groove, wherein the upper cover and bottom groove clamp and fix each other. In the enclosed shell, the upper cover is provided with a sample feed hole. A sample to be detected and other reagents such as coloring agent, eluent, and the like can be added into the shell through the sample feed hole. In the shell, from top to bottom, at least an infiltration layer and a water absorption layer are laminated. The infiltration layer comprises a micro-porous membrane, normal proteins and other micromolecular compounds can penetrate the micro-porous membrane, but protein aggregate which is mistakenly folded cannot penetrate the micro-porous membrane. The micro-porous membrane can be made of cellulose such as cellulose nitrate or cellulose acetate. Preferably, the micro-porous membrane in the infiltration layer comprises a labeling reagent, which can be specifically bound with mistakenly-folded protein aggregate, mistakenly-folded protein aggregate, or a mixture of the labeling reagent and mistakenly-folded protein aggregate.