The invention, which belongs to the radio frequency integrated circuit design technology field, more particularly relates to a Gilbert cell mixer with automatic optimal bias and harmonic wave control. The mixer comprises a basic Gilbert frequency mixing unit, an optimal bias circuit and a harmonic wave control circuit. The Gilbert frequency mixing unit consists of a transconductance level, a switch level, and a load level. The optimal bias circuit includes duplication or reduction with a same proportion of a transconductance-level device of the Gilbert frequency mixing unit, a resistor chain, and operational amplifiers, wherein weak currents flow through the resistor chain and the operational amplifiers form two feedback loops. A middle point of the resistor chain in the optimal bias circuit provides a direct current bias for a transconductance tube in the Gilbert frequency mixing unit. And the harmonic wave control circuit is composed of an adjustable active inductance and a harmonic wave control capacitor; and the harmonic wave control circuit is connected to a drain terminal of the transconductance tube of the Gilbert frequency mixing unit. According to the invention, accuracy of a generated optimal bias is optimized; and a secondary harmonic wave feedback effect is overcome. Besides, the Gilbert cell mixer with automatic optimal bias and harmonic wave control is suitable for application to a wireless communication transceiver circuit needing an active mixer with high linearity.