The present invention provides a method for resource allocation of intelligent urban management grid based on time-space reference, including: constructing a grid object model, which includes case quantity prediction model, regional population distribution model, special vehicle model, rain and snow impact model At least one; build a spatial distribution model, which includes at least one of the regional road network model and the key area model; build a resource allocation model, which includes grid resource allocation coefficients; and the resource allocation model is based on the grid object model and the spatial distribution model Input the comprehensive assignment of the proportion of regional personnel area, regional work characteristics and industry work characteristics, so as to obtain the optimal ratio of resources. The scheme of the present invention changes the traditional mode of human resource allocation based on subjective will, and promotes the transformation of urban management to an intensive and efficient management mode.