A long damping cylinder drive fireproof isolation system comprises a hydraulic control system (1) and a long damping oil cylinder (4); the long damping oil cylinder (4) is connected with the hydraulic control system (1), the upper end of a rectangular isolation body (6) is provided with a steel wire rope (11), the steel wire rope (11) is connected with the long damping oil cylinder (4) by a pulley group (10), one side of the rectangular isolation body (6) is provided with a guide track travel switch (5), a turning plate supporting device (8) and a position limiting travel switch (9). The system is characterized in that a power distribution box (2), a liquid level meter (7), a filter (16), a suspension hook (31), an oil drain plug (33) and an isolation box (30) are arranged on a hydraulic oil tank (29) of the hydraulic control system (1), a motor (18) is arranged in the isolation box (30), a hydraulic pump (17) is connected with the motor (18) by a coupling (15), the hydraulic pump (17) is connected with the oil tank and a cartridge inserted valve; the system has no counterweight, simple transmission system, few easy damaged parts, convenient control and safe and reliable usage.