The invention discloses an indwelling needle controlled-release positive pressure device which comprises a protecting cap, a spiral joint, a front guide pipe, a front tee joint, a controlled-release guide tube, a middle guide tube, a clamp, a rear tee joint, a rear guide tube, a tee joint seat, a positive pressure joint and a liquid storage device. The clamp sleeves the middle guide tube, two ends of the controlled-release guide tube and the middle guide tube are connected with two-hole ends of the front tee joint and the rear tee joint respectively, and other accessories are connected with one another. The indwelling needle controlled-release positive pressure device is characterized by being provided with the two guide tubes, and one is the controlled-release guide tube with a micro hole in the middle while another one is the middle guide tube universal in hole diameter. When the middle guide tube is clamped by the clamp, hydraulic pressure released by the positive pressure joint and the liquid storage device forms pressure, medicine liquid slowly flows out from the micro hole of the controlled-release guide tube to an indwelling needle guide tube component to seep into a blood vessel, and forming of thrombus can be effectively prevented. In addition, when infusion is needed again in the second day, normal infusion can be performed by sterilizing a connecting position, connecting and opening the clamp on the middle guide tube.