The invention discloses a sewing process for shoe uppers and shoe soles of safety shoes. The sewing process for shoe uppers and shoe soles of safety shoes comprises the following steps: P1, carrying out shearing forming; P2, carrying out lining fixing; P3, carrying out edge trimming; P4, carrying out first-time bonding; P5, carrying out punching; P6, carrying out thread sewing, namely, selecting the thread with the suitable model number, and enabling the thread to sequentially pass through the punched holes for realizing the thread sewing operation; P7, carrying out second-time bonding; and P8, carrying out drying. For the sewing process for the shoe uppers and the shoe soles of the safety shoes provided by the invention, due to the placement of the linings adhered inside the shoe uppers,the comfort can be improved, punching is carried out after position fixing through the first-time bonding, so that the stability of the position can be guaranteed, the deviation dislocation can be avoided, meanwhile, filling sizing is carried out through coating of self-adhesive glue, so that the sewing stability can be guaranteed, the generation of gaps is avoided, then the stability of sewing ofthe safety shoes is greatly improved, the existing process is improved, and the use and popularization are facilitated.