The invention provides a large-sized static mixer. The large-sized static mixer comprises a pipeline and a mixing unit arranged in the pipeline, wherein openings are formed in two ends of the pipeline; the mixing unit comprises a first blade, a second blade, a third blade and a fourth blade which are of a circular arc sheet shape; the first blade and the second blade are arranged in an opposite crossing manner, the axis of the crossing point is level, the first blade forms a downward deflection angle around the axis of the crossing point, and the second blade forms an upward deflection angle around the axis of the crossing point; the third blade and the fourth blade are arranged in an opposite crossing manner, the axis of the crossing point is vertical, the third blade forms a right deflection angle around the axis of the crossing point, and the fourth blade forms a left deflection angle around the axis of the crossing point; the rear end of the first blade is connected with the plate surface of the third blade, the rear end of the second blade is connected with the plate surface of the fourth blade, the front end of the third blade is connected with the plate surface of the second blade, and the front end of the fourth blade is connected with the plate surface of the first blade. By virtue of a special blade combination manner, the integral structural strength of the mixer is enhanced, and by virtue of a reasonable integral structure, the mixer has excellent mixing efficiency.