35results about How to "Rational design" patented technology

This invention provides protection against an electricity leak and prevents error in reverse wiring. Also, when the ground fault circuit interrupter has come to the end of its life and its functions fail, it can set off an alarm prompt signal, reminding the user to replace the interrupter in a prompt manner; when a certain part or accessory of the ground fault circuit interrupter fails, especially when the primary electromagnetic coil cannot work in a normal manner, the power output of the interrupter may be cut off through the secondary electromagnetic coil; or the test button may be pressed to mechanically cut off the power output of the interrupter. This invention has powerful applications, with good safe guard and is safe to use, thus effectively ensuring the personal safety of the user as well as the safety of the appliances.

The present invention relates to pet sock and a manufacturing method thereof, relating to the technical field of pet supplies. The present invention has solved the technical problems in the prior arts and provides a much more reasonable design. The pet sock provided by the present invention each comprises a sock body, a sock bottom for accommodating a foot of a pet which is communicated with the sock body, and a sock opening for a foot of a pet to get in or out being provided on the sock body, the pet sock being characterized in that an elastic waterproof layer made of elastic waterproof material is compounded on an outer side of the sole of the sock bottom. Compared with the prior arts, the pet sock and the manufacturing method thereof have the following advantages: the design of the pet sock is much more rational and the structure thereof is simpler; as an anti-slide-off structure is provided, the sock can be secured onto the leg of the pet and are unlikely to slide off; meanwhile, due to the arrangement of a shield sleeve, the anti-slide-off structure can be shielded, so that the pet sock look more beautiful and become warmer; in addition, the arrangement of the elastic waterproof layer can provide much more comfort and protect the feet of pets from injuries.

The invention is directed to a model system for structure-activity analysis of peptide or protein molecules involved in important biological processes. Provided by the invention are combinatorial peptide libraries comprising disulfide-constrained cyclic peptides with sequences favorable for energy stabilized conformations. A preferred embodiment of the invention is directed to peptides containing β-turn tetrapeptide that form structured β-hairpin scaffold in solution. Methods of selecting and using such peptides are provided herein, which are useful for mimicking in vivo molecular interactions and designing therapeutic agents. Thus, the invention has profound utility for biological studies and drug development.

The present invention relates to methods and systems for the accurate prediction of nucleic acid, e.g., RNA and DNA, and other macromolecular and biomolecular three-dimensional structure from sequence and constraint information.

The invention relates to compounds of formula (I):useful for treating disorders mediated by acyl coA-diacylglycerol acyl transferase 1 (DGAT1), e.g. metabolic disorders. The invention also provides methods of treating such disorders, and compounds and compositions etc. for their treatment.

The invention relates to compounds of formula (I):where A is an optionally substituted heteroaryl, useful for treating disorders mediated by acyl coA-diacylglycerol acyl transferase 1 (DGAT1), e.g. metabolic disorders. The invention also provides methods of treating such disorders, and compounds and compositions etc. for their treatment.

A connecting device for light fixtures has a lens fixing plate, a light fixture assembly, a button, a first spring, a connecting rod and a buckle. The buckle is fixedly connected to the light fixture assembly. A mounting base is disposed on the lens fixing plate. One end of the connecting rod is located in an inner cavity of the mounting base and the other end thereof is extended out from the mounting base. The end of the connecting rod extending out from the mounting base is provided with a boss, and the connecting rod located in the inner cavity of the mounting base is sleeved with the first spring. The button is connected to the end of the connecting rod located in the inner cavity of the mounting base.

An equipment for the pressurized adsorption of gaseous carbon dioxide from boiler flue gas for oil recovery by well injection comprising a boiler for generating high pressure steam, a high pressure water pump, a tower scrubber, a compressor, an absorber, a separation tank, a flash pot, a solvent pump, a stripper, an air pump, a carbon dioxide compressor, a purifier, a carbon dioxide pressurizer, a drying beds, a membrane module, a nitrogen pressurizer and a mixing tank. With rational design and handsome practicability, the comprehensive mate equipment, when producing steam by the boiler, can obtain carbon dioxide liquid and nitrogen, thus realizing “single injection”, “double injection” or “triple injection” of steam, gaseous carbon dioxide and nitrogen and thereby gaining favorable results of crude oil output increase as well as environment protection.

The present invention relates to methods and systems for the accurate prediction of nucleic acid, e.g., RNA and DNA, and other macromolecular and biomolecular three-dimensional structure from sequence and constraint information.

A gas lighting device including: a body formed by an electrically insulating material carrying a plurality of high-voltage outputs for the connection of spark generating means; a transformer accommodated in the body and including a primary winding wound around and carried by a ferromagnetic material core, a carrying element formed by an electrically insulating material and designed to contain the primary winding therein, and a secondary winding consisting of a plurality of coils externally carried by the carrying element, electrically insulated from the primary winding and essentially coaxial with the latter; the core is ring-shaped on a plane parallel to an axis (A) of the windings and consists of two half rings reciprocally coupled and arranged facing and closely adjacent to each other in the direction of the axis of the windings; a first circumferential portion of the ring-shaped core, formed by one or both of the half rings, is accommodated inside the carrying element so as to be surrounded by the windings, while a second circumferential portion of the core is formed parallel to the first and radially on the outside of the windings so as not to be surrounded by the same.

LED lamp beads with multiple light-emitting points comprising a certain number of luminous bodies and package resins; in which after at least two luminous bodies are connected in parallel, they are wrapped in a package resin and connected to an anode pin and a cathode pin inserted into the package resin. The present invention structure is simple and has a rational design. By using one-way conductive luminance on the LED luminous bodies, and using parallel and inverse parallel connections on multiple light-emitting points, control of the electric current direction is achieved, and thus the control of the operating modes of luminous bodies and the LED lamp beads with multiple light-emitting points is achieved.

The present invention relates to genetically modified enzymes obtained by rational design of the active site binding pocket of the prototypic enzyme 4-hydroxyphenylacetate 3-hydroxylase (4HPA3H) for hydroxylating a 4-hydroxyphenyl compound to yield a 3,4-dihydroxyphenyl compound and to biotechnological methods including in vivo and in vitro methods using said enzymes or catalytically active fragments thereof. Further provided is a method either using a suitable oxidase or hydroxylase further enabling the subsequent site specific methylation of the 3,4-dihydroxyphenyl compound in a coupled enzymatic reaction by providing a suitable O-methyltransferase. Finally, compositions obtainable by the aforementioned methods are disclosed.

The present invention offers a type of chair cushion and its supporting structure, and belongs to the technical field of chair manufacture. It solves the problem of unreasonable design in prior art. The chair cushion and its supporting structure comprise a pair of side boards and a bottom board. The undersides of the pair of side boards are provided at both sides of the bottom board to form a mounting cavity in which are provided several elastic supporting components. Each elastic supporting component includes several vertical springs of identical size and shape and a first flexible cladding. All springs in each elastic supporting components are arranged in at least one row and cladded in the first flexible cladding. The advantages of the chair cushion and its supporting structure lie in that the elastic supporting components formed by the first flexible cladding that clads at least one row of springs promote the strength for supporting person's hip weight on the seat. Due to the promoted buffer capacity, the protection role is enhanced to the person sitting in the seat.

The invention relates to compounds of formula (I): useful for treating disorders mediated by acyl coA-diacylglycerol acyl transferase 1 (DGAT1), e.g. metabolic disorders. The invention also provides methods of treating such disorders, and compounds and compositions etc. for their treatment.