The present invention relates to a high-intensity focused ultrasound device, and more specifically, to a high-intensity focused ultrasound device which has a structure changed so as to enable a disposable separable cartridge to be attached and detached, and which enables a doctor, who is the person performing a procedure, to obtain, through a scanning unit of a transducer for ultrasonic conversion, coordinates of a skin tissue of a subject undergoing the procedure, thereby allowing for an accurate procedure point to be checked in real time, thus allowing for a procedure to be performed on an accurate point on a skin tissue, without repeated procedures. The present invention relates to a high-intensity focused ultrasound device comprising a hand piece comprising: a hand piece body electrically connected by a wire to a freely movable moving body; and a separable cartridge disposably coupled to the hand piece body. The hand piece body comprises: a laser generator which fractionally transfers energy so as to facilitate the synthesizing of collagen; a transducer for ultrasonic conversion which receives electrical energy that has been impedance-matched by going through the processes of frequency generation and power amplification, converts the electrical energy into high-intensity focused ultrasound and irradiates same, or which receives reflected ultrasound; and an X-Y reflection mirror which undergoes in parallel a forward / backward movement and a tilting movement inside the hand piece body, and consecutively forms HIFU foci in a single row, or consecutively forms HIFU foci in aplurality of rows, or consecutively forms foci in a circular shape; a cooling device which supplies cooling gas to the separable cartridge; and a zoom-in device which zooms-in an image formed by thereflected ultrasound. The separable cartridge comprises: a cooling passage which enables cooling gas to be injected and to flow on the bottom surface of the separable cartridge, thereby lowering the temperature; and a transparent transmittance member which supports the cooling passage, and adheres to a skin tissue so as to enable the laser and the high-intensity focused ultrasound to pass throughand reach the skin. The moving body comprises: a control unit comprising a transducer for ultrasonic conversion-module, a reflection mirror control module, a cooling module and a coordinate module, the transducer for ultrasonic conversion-module controlling the processes of frequency generation and power amplification of the transducer for ultrasonic conversion, and controlling power, frequency, duty cycle, focus size and pulse repetition frequency, the reflection mirror control module controlling the forward / backward movement and the tilting movement of the X-axis and the Y-axis of the reflection mirror, the cooling module lowering the temperature of the cooling device if re-treatment is performed, and the coordinate module receiving information on coordinates converted through the transducer for ultrasonic conversion, and figuring out a site that is currently being treated; a monitor unit comprising an indicator for indicating information related to a procedure of a person performingthe procedure, and a touch screen for the person performing the procedure to operate or control the high-intensity focused ultrasound generation device; and a power unit for supplying high-intensityfocused ultrasound power.