The invention discloses a switch power supply circuit and an adjusting method thereof. The switch power supply circuit comprises a main circuit, an I<2>C bus module, a control circuit, and a buffer circuit; the main circuit comprises a switch node and a main switch tube controlled by a switch signal, and the main circuit comprises a first grounding end, an input end for receiving an input DC signal, and an output end for providing an output DC signal; the I<2>C bus module generates control data; the control circuit generates the switch signal according to the control data and/or the output DC signal, and generates an adjustment data signal according to the control data; and the buffer circuit is connected between a second grounding end and the switch node of the main circuit, and resistance and capacitance values of the buffer circuit are controlled by the adjustment data signal, so repeated welding and removal do not need to be performed on the buffer circuit, a buffer grounding path matching the main circuit of the switch power supply circuit is provided at a position of the switch node then, and signal waveform integrity and debugging efficiency at the position of the switch node are improved.