The invention relates to a wool, cotton and cotton polyester interweaving weft knitting double-faced pile fabric. According to the fabric, pure-cotton silvalin is adopted as looped pile inner yarn, wool is adopted as middle connection yarn, cotton polyester silvalin is adopted as surface layer yarn, the pure-cotton silvalin, the wool and the cotton polyester silvalin are woven on a single-face circular weft knitting fleece machine to form a stitched looped pile fabric, in the weaving process, the wool middle connection yarn generates wool exposed points on the outer surface of the cotton polyester fiber surface layer, and the wool exposed points account for 30-33% of the area of the cotton polyester fiber surface layer; the looped pile inner yarn is napped, the wool exposed points are sanded to obtain the weft knitting double-faced pile fabric with the pure-cotton gigging inner layer, the wool connection layer, the cotton polyester surface layer and the wool felt layer, wherein the pure-cotton silvalin accounts for 52-57%, the wool accounts for 7-22% and the cotton polyester silvalin accounts for 22-27%. The fabric has the advantages of being fine in suede, high in wool touch, soft and full in hand touch, good in heat retention property, good in breathability, good in mold holding nature, capable of resisting static electricity and low in price.