55 results about "Lifestyle related disease" patented technology

The oil or fat composition of the invention contains a monoacylglycerol and / or a diacylglycerol in a total amount of 5-100 wt. % and which exhibits an index of stability against oxidation (induction time as measured through a Rancimat test conducted at 100° C.) of 7 or higher, wherein the monoacylglycerol and / or the diacylglycerol contain, as fatty acid constituents, ω3 unsaturated fatty acids in amounts of 15-90 wt. %. Through ingestion thereof in a small amount without drastically changing the person's lifestyle, the highly harmless oil / fat composition of the present invention provides effects for reducing and preventing accumulation of body fat, for reducing and preventing accumulation of visceral fat, and for prevention and treatment of obesity; and exerts an excellent prevention and treatment effect on life-style related diseases through long-term ingestion. Thus, the composition of the present invention is useful for foods, pharmaceuticals and pet food or feed.

An object of the present invention is to provide a scavenger of in vivo harmful reactive oxygen species and / or free radicals, which is capable of effectively reducing the concentrations of in vivo reactive oxygen species and / or free radicals and exhibiting given effects such as the suppression of aging process, the prevention of geriatric or lifestyle-related disease, health promotion, and the inhibition of oxidative stress by virtue of this reduction in the concentrations of reactive oxygen species and / or free radicals. The scavenger of in vivo harmful reactive oxygen species and / or free radicals of the present invention comprises a liquid or gas comprising at least a hydrogen molecule. This medium may further comprise an oxygen molecule. Furthermore, this medium may comprise water or an aqueous solution or may be a gas. The scavenger of reactive oxygen species and / or free radicals can be used in the treatment or prevention of a disorder attributed to reactive oxygen species and / or free radicals.

(Problems) To provide a highly safe dietetic composition originating in green coffee beans by which excellent dietetic effects can be obtained and which contributes to the prevention and treatment of life style-related diseases such as diabetes.(Means for Solving Problems) A dietetic composition characterized by comprising, as the active ingredient, a polar solvent extract of defatted green coffee beans. It is preferable that the above-described polar solvent extract is an extract obtained by using water-containing ethanol, still preferably water-containing ethanol having an ethanol concentration of from 40 to 90% (wt / wt). It is preferable that the above-described defatted green coffee beans are those obtained by extracting green coffee beans with N-hexane to thereby separate oily components therefrom. It is recommended to combine the above-described dietetic composition with one or more members selected from among salacia extract, evening primrose extract, sesamine and garcinia. This dietetic composition is usable as a material for foods, drinks, drugs, or skin preparations for external use.

A pharmaceutical composition is provided having at least one kind to be selected from the group consisting of a lactoferrin group protein having lactoferrin and conalbumin, and an enzymatically decomposed product of the lactoferrin group protein having peptides corresponding to lactoferricin and lactoferricin of conalbumin as an active ingredient. The composition of the present invention can be used as an agent for improving lipid metabolism. Further, it is useful for treating hypercholesterolemia, hyper-neutral lipidemia, hyper-low density lipoprotein (LDL) cholesterolemia, hypo-high density lipoprotein (HDL) cholesterolemia, obesity, fatty liver and cholesterol gallstone and lifestyle-related diseases such as severe obesity, hyperlipidemia, hypertension and type II diabetes. The composition of the present invention can improve basal metabolic rate.

An increase in body fat is one of main causes of life-style-related diseases such as hypertension, insulin tolerance and hyperlipemia. A composition for body fat reduction is provided which inhibits body fat from decreasing or decreasing which and which is effective in the treatment and prevention of adult diseases a cause of which is body fat. Also, provided are a medicine and a food each containing the composition.The composition for body fat reduction comprises (A) astaxanthin and (B) at least one of active ingredient, an adsorbent and a solubilizer, a composition comprises (A) Haetmatococcusalga extract containing astaxanthin and (B) at least one of active ingredient, an adsorbent and a solubilizer, and a medicine and food, each containing the composition are provided.

There is provided a portable terminal device, and a lifestyle-related disease patient—medical institution cooperation system, which collects a user's biological data and life data, so that it is possible to quickly receive advice from a specialist, and data accumulation and analysis over a long period is possible, to accurately comprehend deviations in lifestyle habits and the life of a patient, and to give a highly reliable medical service. The invention is a terminal device which can be carried by the user, comprising: a measuring unit which measures the user's in-vivo substance so as to obtain biological data; an input unit which can input life data including at least the user's food intake contents; a data storage unit which readably stores basic data including the biological data and the life data, and a display unit which displays the data.

To prevent or alleviate various pathologies caused by lifestyle-related diseases, etc., the present invention provides a substance having an effect of promoting the expression and elevating the expression level of adiponectin, and applications thereof. An adiponectin expression promoting agent containing, as an active ingredient, at least one cyanidin compound selected from the group consisting of cyanidin and cyanidin glycosides can be applied to pharmaceutical or food compositions for use in applications in which the pharmacological effects of adiponectin are utilized.

The present invention relates to provision of AMPK activating agent, endurance enhancing agent, and antifatigue agent, which have rich history of use in foods, high safety, readily available, and high workability, a method of activating AMPK, and a method of preventing, treating and / or ameliorating a life-style-related disease. The present invention provides AMPK activating agent, endurance enhancing agent, and antifatigue agent, each of which contains nootkatone as an active agent. The present invention provides a method of activating AMPK characterized by administering nootkatone in an effective amount, and a method of preventing, treating and / or ameliorating a life-style-related disease characterized by administering nootkatone in an effective amount.

The present invention provides a pharmaceutical composition having at least one kind to be selected from the group consisting of a lactoferrin group protein comprising lactoferrin and conalbumin, and an enzymatically decomposed product of the lactoferrin group protein comprising peptides corresponding to lactoferricin and lactoferricin of conalbumin an active ingredient. The composition of the present invention can be used as an agent for improving lipid metabolism. Further, it is useful for treating hypercholesterolemia, hyper-neutral lipidemia, hyper-low density lipoprotein (LDL) cholesterolemia, hypo-high density lipoprotein (HDL) cholesterolemia, obesity, fatty liver and cholesterol gallstone and lifestyle-related diseases such as severe obesity, hyperlipidemia, hypertension and type II diabetes. The composition of the present invention can improve basal metabolic rate.

The dynamic property of a blood flow in a superficial blood vessel of a living body are constructed.A physical stimulus is given to the blood flow, and an ultrasonic response from the blood flow to the physical stimulus is measured and evaluated, which allows the blood property to be evaluated noninvasively and dynamically. Therefore, a medical check and a lifestyle-related diseases prevention effect are promising.

(Problems) To provide a highly safe dietetic composition originating in green coffee beans by which excellent dietetic effects can be obtained and which contributes to the prevention and treatment of life style-related diseases such as diabetes.(Means for Solving Problems) A dietetic composition characterized by comprising, as the active ingredient, a polar solvent extract of defatted green coffee beans. It is preferable that the above-described polar solvent extract is an extract obtained by using water-containing ethanol, still preferably water-containing ethanol having an ethanol concentration of from 40 to 90% (wt / wt). It is preferable that the above-described defatted green coffee beans are those obtained by extracting green coffee beans with N-hexane to thereby separate oily components therefrom. It is recommended to combine the above-described dietetic composition with one or more members selected from among salacia extract, evening primrose extract, sesamine and garcinia. This dietetic composition is usable as a material for foods, drinks, drugs, or skin preparations for external use.

A seawater mineral component-containing composition is produced which contains mineral components having a good effect on health, such as magnesium and calcium, has a decreased content of sodium, and thus can be used widely for foods. When processed, the seawater mineral component-containing composition provides foods and beverages useful for preventing cardiovascular diseases and lifestyle-related diseases. The seawater mineral component-containing composition is obtained by subjecting seawater to electrodialysis, and has a sodium concentration of 6 mg / L or less when adjusted to form an aqueous solution having a hardness of 100 (EDTA method).

Novel and highly effective agents for suppressing fat accumulation and for suppressing body fat gain that contain astaxanthin and / or an ester thereof as an active component are provided. The agent for suppressing fat accumulation according to the present invention effectively suppresses accumulation of fat both in subcutaneous fat and in visceral fat. Even when high-fat diet intake is continued, body weight gain is suppressed by using the agent for suppressing body weight gain according to the present invention. Therefore, life-style related diseases, which are very likely to be caused by obesity, can be prevented, and the agents can be also used as an agent for preventing or alleviating a disease or a symptom having a relation to fat accumulation.

The present invention provides an impaired glucose tolerance ameliorating drug and a therapeutic drug for lifestyle-related diseases, particular an antidiabetic drug, which contain a CXCR3 agonist as an active ingredient; a hypoglycemia ameliorating drug, a therapeutic drug for insulinoma or an anti-obesity drug containing a CXCR3 antagonist as an active ingredient; a method of screening for a new CXCR3 ligand using CXCR3 and a known CXCR3 ligand; a method of screening a CXCR3 ligand, which uses a co-expression system of CXCR3 and a coupling G protein; and a diagnostic method for type II diabetes, which includes detecting an amount of a CXCR3 ligand expressed in a biological sample.

The present invention provides a novel therapeutic agent for a lifestyle-related disease or cibophobia, which is superior in controlling food intake, and a screening method therefor. More specifically, a therapeutic agent for a lifestyle-related disease containing, as an active ingredient, a substance that suppresses expression or function of GPCR that expresses in hypothalamus, clone 901, a therapeutic agent for cibophobia containing, as an active ingredient, a substance that enhances expression or function of the clone, a screening system consisting of a series of coexpression systems of clone 901 and various G proteins, and a screening method for a substance having a therapeutic activity against a lifestyle-related disease or cibophobia, which includes use of the screening system, are provided.

The present invention has its object to provide an agent for preventing and / or ameliorating life style-related diseases which contains, as an active ingredient, a substance derived from a safe food material having a long history of being eaten as a food and which is capable of being utilized as functional foods such as health foods or functional health foods (specific health foods, functional nutritive foods).The agent for preventing and / or ameliorating life style-related diseases according to the invention contains, as an active ingredient, at least one compound selected from the group consisting of ar-turmerone, α-turmerone, β-turmerone, curlone, bisacumol and β-sesquiphellandrene, or at least one compound selected from among the bisabolane type sesquiterpenoids derived from Curcuma longa L., and therefore is useful for preventing and / or ameliorating diabetes, visceral fat obesity, metabolic syndrome and obesity, among others.

The present invention provides a blood flow promoting agent containing citrulline or a salt thereof and capsaicin or capsaicinoids as active ingredients, which is safe even by long-term administration, a food with health claims and a functional food affording such action, particularly, a blood flow promoting agent exhibiting an effective vasodilatory action of capsaicin at a low dose free of irritant property, which can be applied to improvement of athletic performance exhibited in relation to peripheral vasodilatation, suppression of fat accumulation, improvement of skin quality, as well as securing blood circulation in ischemic disease and the like, relaxation of blood vessel biased to coarctation due to advancing age, lifestyle-related diseases and the like, prophylaxis of arteriosclerosis, and prophylaxis of stiff neck, feeling of cold, erectile dysfunction, thrombosis and the like due to blood flow disorder.

The object of the invention is to provide a composition for prevention and / or amelioration of life-style related disease, and / or a composition for inhibition and / or amelioration of increase in body weight, comprising at least one compound selected from the group consisting of glabrene, glabridin, glabrol, 3′-hydroxy-4′-O-methylglabridin, 4′-O-methylglabridin and hyspaglabridin B as compounds having a PPAR ligand activity effective in amelioration of insulin resistance and in prevention and / or amelioration of life-style related diseases such as visceral fat obesity, type 2 diabetes, hyperlipemia and hypertension, which can be utilized in food and drink such as health food and health functional food (food for specified uses and food with nutrient function), pharmaceutical preparations, non-pharmaceutical preparations, cosmetics etc. At least one compound selected from the group consisting of glabrene, glabridin, glabrol, 3′-hydroxy-4′-O-methylglabridin, 4′-O-methylglabridin and hyspaglabridin B is dissolved in medium-chain fatty acid triglycerides and / or partial glycerides, whereby the stability of the compound(s) is improved and the processability thereof into food and drink, pharmaceutical preparations, non-pharmaceutical preparations, cosmetics etc. is also improved.

Provided are a method for measuring glycated hemoglobin in a sample, characterized in that glycated hemoglobin in a sample is directly oxidized, and a substance produced thereby, or a substance consumed thereby, is measured; and a method for measuring glycated hemoglobin in a sample, characterized in that, using an enzyme, glycated hemoglobin in a sample is directly oxidized, and a substance produced thereby, or a substance consumed thereby, is measured. This method for measuring glycated hemoglobin is useful in diagnosing lifestyle-related diseases such as diabetes.

The present invention provides a lactobacillus that improves hyperuricemia, fatty liver and a lifestyle-related disease, and a composition containing the lactobacillus.

The present invention relates to a beverage containing bamboo extract as a main ingredient, for details, a beverage containing bamboo extract as the main ingredient, which is useful for amelioration of diabetes, cancer, life-style related diseases or the like. A beverage characterized in containing, as the main ingredient, bamboo extract obtained through the process comprising the steps by immersing bamboo in water and extracting the bamboo extract with heating the water to 95° C. or higher and maintaining the temperature for a period of 2 hr 45 min to 3 hr 15 min.

The object of the present invention is to provide a biomarker which is highly correlated to the conventional biomarkers of metabolic syndrome or life-style related disease in a wide range of subjects to be tested, including subjects of special health check-up aged between 40 and 74, or an advantageous method for detecting metabolic syndrome or life-style related disease. The object can be solved by a method for detecting metabolic syndrome or life-style related disease characterized by comprising the step of measuring the concentration of choline plasmalogen in a sample to be tested.

The present invention provides a therapeutic or improving agent for a lifestyle-related disease, containing an expression vector encoding a chimeric Hepatitis B virus core antigen polypeptide inserted with an amino acid sequence containing a specific epitope of the lifestyle-related disease-related factor, wherein the amino acid sequence containing the specific epitope is inserted between the amino acid residues 80 and 81 of the hepatitis B virus core antigen polypeptide.

A composition contains 0.1 to 10 g of dried Hercampuri extract obtained by extracting the essence of dried whole Hercampuri plant with 60 to 80% aqueous ethanol. It has a function of prevention or curative treatment of lifestyle-related disorders induced by accumulation of visceral fat resulting from excessive calorie intake. It is useful for maintaining, improving and promoting health.

The objects of this invention are to prevent or ameliorate hypertension to improve physical constitution and finally to provide feeds, drinks, foods, health food supplements and pharmaceuticals which may be led to the prophylaxis or amelioration of life style related diseases. A prophylactic or ameliorating agent of hypertension comprising conjugated fatty acids (e.g., conjugated linoleic acid) as effective ingredients. A feed, food and drink, and health food supplement comprising the conjugated fatty acids described above. A pharmaceutical comprising the conjugated fatty acids described above. A method for prophylactic or ameliorating of hypertension in a mammal, which comprises administering to the mammal an effective amount of a conjugated fatty acid for preventing or ameliorating of hypertension in the mammal. Use of a conjugated fatty acid for preparing a pharmaceutical for prophylactic or ameliorating of hypertension.

An object of the present invention is to provide a scavenger of in vivo harmful reactive oxygen species and / or free radicals, which is capable of effectively reducing the concentrations of in vivo reactive oxygen species and / or free radicals and exhibiting given effects such as the suppression of aging process, the prevention of geriatric or lifestyle-related disease, health promotion, and the inhibition of oxidative stress by virtue of this reduction in the concentrations of reactive oxygen species and / or free radicals. The scavenger of in vivo harmful reactive oxygen species and / or free radicals of the present invention comprises a liquid or gas comprising at least a hydrogen molecule. This medium may further comprise an oxygen molecule. Furthermore, this medium may comprise water or an aqueous solution or may be a gas. The scavenger of reactive oxygen species and / or free radicals can be used in the treatment or prevention of a disorder attributed to reactive oxygen species and / or free radicals.

A fat composition for oral or enteral administration which contains eicosapentaenoic acid and / or a derivative thereof, docosahexaenoic acid and / or a derivative thereof, and a C20 or higher monoenoic acid and / or a derivative thereof and functions to diminish hexacosanoic acid; and a hexacosanoic acid depressant which comprises as active ingredients eicosapentaenoic acid and / or a derivative thereof, docosahexaenoic acid and / or a derivative thereof, and a C20 or higher monoenoic acid and / or a derivative thereof. They can be prepared by extraction from a fish oil or the like, purification, blending, etc. Based on the function of diminishing hexacosanoic acid, the composition and the depressant produce an aging-inhibitory effect on cell membranes, which is effective in the prevention and treatment of lifestyle-related diseases.

The objects of this invention are to prevent or ameliorate hypertension to improve physical constitution and finally to provide feeds, drinks, foods, health food supplements and pharmaceuticals which may be led to the prophylaxis or amelioration of life style related diseases.A prophylactic or ameliorating agent of hypertension comprising conjugated fatty acids (e.g., conjugated linoleic acid) as effective ingredients.A feed, food and drink, and health food supplement comprising the conjugated fatty acids described above.A pharmaceutical comprising the conjugated fatty acids described above.A method for prophylactic or ameliorating of hypertension in a mammal, which comprises administering to the mammal an effective amount of a conjugated fatty acid for preventing or ameliorating of hypertension in the mammal.Use of a conjugated fatty acid for preparing a pharmaceutical for prophylactic or ameliorating of hypertension.