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56 results about "Conjugated fatty acid" patented technology
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Conjugated fatty acids are polyunsaturated fatty acids in which at least one pair of double bonds is separated by only one single bond. An example of a conjugated fatty acid is the conjugated linoleic acid. Conjugated fatty acids may confer health benefits ranging from the prevention of hypertension to protection against certain forms of cancer, although more research is needed to confirm such effects.
Self emulsifying compositions for delivering lipophilic coenzyme Q10 and other dietary ingredients
InactiveUS20060051462A1Oral administration is convenientIncrease loadOrganic active ingredientsFood ingredientsSolubilityDietary supplement
The present invention provides novel dietary supplement compositions based on the use of a particular oil phase which comprises of Coenzyme Q10 and optionally other lipophilic dietary ingredients of low water solubility and a liquid mixture which comprises one or more emulsifiers, a fatty acid monoester formed between an short chain alcohol of C1 to C4 chain length and a saturated, or mono-unsaturated, or di-unsaturated (both conjugated and non-conjugated) fatty acid of C6 to C24 chain length, or medium chain mono- / di-esters, or the mixture of above. The composition is in a form of self-emulsifiable in the aqueous medium, for example, a simulated gastric fluid, which should provide a high oral bioavailability for the lipophilic dietary ingredients.
Owner:WANG JIMMY X
Process for preparing conjugated fatty acid
The invention provides a specific isomerase produced from lactic acid bacteria, wherein biological isomerization is employed for preparing conjugated aliphatic acid, the enzyme isomerizes 9c, 12c unsaturated fatty acid to form 9c, 11t conjugated aliphatic acid, such as 9c, 11t conjugated linolic acid, 9c, 11t conjugated linolenic acid. The invention also discloses the process for preparing conjugated aliphatic acid by conducting mutagenesis, modification, isomerase gene cloning to lactic acid bacteria, and various products of the prepared conjugated aliphatic acid and lactic acid bacteria product related with conjugated aliphatic acid.
Owner:NANCHANG UNIV
Methods for the treatment of HIV-1 related fat maldistribution, fasting hyperlipidemia and modification of adipocyte physiology
InactiveUS20080114065A1Treating and preventing and normalizing lipoatrophyIncreased serum lipidsBiocidePeptide/protein ingredientsThiolSecondary hyperlipidemia
Methods for treating or preventing metabolic dysregulation of adipocytes resulting from HIV-1 infection or chronic inflammation are disclosed. The compositions contain a conjugated fatty acid, a thiol-containing compound and a bioavailable form of trivalent chromium.
Owner:POPULATION RES
Method for producing conjugated linoleic acid glycerides
ActiveUS20050176977A1Fatty oils/acids recovery from wasteFatty acid isomerisationIsomerizationGlycerol
Processes for preparing conjugated fatty acid glycerides comprising: (a) isomerizing a fatty acid lower alkyl ester corresponding to the general formula (I) in the presence of a basic catalyst at a temperature of from 100 to 160° C., to form a conjugated fatty acid lower alkyl ester: R1CO—OR2 (I)wherein R1CO represents an acyl radical having from 16 to 22 carbon atoms and at least two carbon-carbon unsaturations and R2 represents an alkyl radical having from 1 to 4 carbon atoms; and (b) transesterifying the conjugated fatty acid lower alkyl ester with glycerol to form a conjugated fatty acid glyceride, wherein a lower alkanol corresponding to the general formula R2OH is formed, wherein R2 is as defined above, and the lower alkanol is continuously removed from the transesterification reaction; are described.
Owner:COGNIS DEUT GMBH & CO KG
Fatty amide composition for wet use chopped strand glass fibers
InactiveUS20050276960A1Improve mechanical propertiesHigh tear strengthRoof covering using tiles/slatesRoof covering using flexible materialsGlass fiberFilm-forming agent
A size composition containing one or more film forming agents, at least one coupling agent, and a fatty amide lubricant synthesized from a (poly)ethylene amine and a C5-C20 unsaturated fatty acid is provided. The fatty acid is preferably a conjugated fatty acid and the (poly)ethylene amine is preferably tetraethylenepentamine. The fatty amide lubricant may be modified by maleinized rubber or carboxylated rubber. The size is advantageously applied to glass fibers such as wet use chopped strand glass and used to form roofing composites, such as shingles. The fatty amide lubricant facilitates interfacial bonding between the glass and asphalt through a vulcanizing mechanism. The unsaturation of the fatty amide modifies the surface energy of the glass fibers to make the glass more compatible with the asphalt, enhances the compatibility between the glass and the asphalt, and improves glass / asphalt interactions through the reduced interfacial tensions.
Owner:OCV INTELLECTUAL CAPITAL LLC
Method for producing oxo fatty acid and rare fatty acid
ActiveUS20150125911A1Efficient productionEfficient conversionMicroorganismsMicroorganism based processesLactic acid bacteriumIsomerase
The present invention provides a production method of oxo fatty acid, as well as rare fatty acids such as conjugated fatty acid, hydroxylated fatty acid, partially saturated fatty acid and the like, which uses 4 kinds of enzymes (fatty acid-hydratase, hydroxylated fatty acid-dehydrogenase, oxo fatty acid-isomerase, oxo fatty acid-enone reductase) derived from Lactobacillus plantarum including lactic acid bacteria and the like. Furthermore, the present invention also provides a more efficient production method of oxo fatty acid and the like, which partly uses a chemical oxidation reaction in combination.
Owner:NOSTER INC +1
Production of conjugated linoleic and linolenic acids in plants
InactiveUS20020045232A1Efficient productionLittle side effectsSugar derivativesOther foreign material introduction processesPlanting seedAcyl group
The present invention relates to methods for large-scale production of conjugated fatty acids, especially conjugated linoleic acids in plants. More specifically, the present invention relates to genes identified from Calendula officinalis coding for a conjugase and its related enzyme, a .DELTA.12 desaturase, and utilization of them for large scale production of conjugated linoleic and linolenic acids in plants. The genes encoding a conjugase can introduce two conjugated double bonds at 8 and 10 positions, and a .DELTA.12 desaturase can introduce a double bond at 12 position of acyl chains. The constructs containing these genes can be transferred to plants with different substrate profiles, which allows for the production of conjugated linoleic acids (18:2, .DELTA.8, .DELTA.10) and linolenic acids (18:3, .DELTA.8, .DELTA.10, .DELTA.12) in plant seeds on a commercial scale.
Owner:BIORIGINAL FOOD & SCI
Fermented foods and process for producing the same
InactiveUS20070031536A1Great tasteImproved digestibility and absorptionMilk preparationLactobacillusFermentationInhibitory effect
The present invention relates to a fermented food and process for producing the same, in which the food contains a sufficient amount of conjugated fatty acid and is excellent in digestivity and absorbability, physiological effects, safety, sensory properties, and the like. The fermented food is obtained by adding a conjugated fatty acid in the form of a glyceride to a fermentation medium either before or after the fermentation by the fermenting bacterium, and the final fermented food product contains such conjugated fatty acid in the form of a glyceride. The conjugated fatty acid of the glyceride type is a glyceride derivative containing a fatty acid having conjugated double bonds (a conjugated fatty acid) as its constituent fatty acid, and sustains many of useful physiological activities of the conjugated fatty acid while coping with the inhibitory action of free fatty acids to the fermenting bacterium.
Owner:YAKULT HONSHA KK
Method for commercial preparation of preffered isomeric forms of ester free conjugated fatty acids with solvents systems containing polyether alcohol solvents
InactiveUS20040015001A1Fatty acid isomerisationOrganic compound preparationIodo fatty acidIsomerization
Methods for sequential saponification and quantitative isomerization of glyceride oils containing interrupted double bond systems, with alkali in a polyether alcohol solvent to yield soaps with conjugated double bond systems are disclosed. The novel properties f the polyether alcohols allow the removal of water added with the alkali by boiling. The preferred embodiment uses a vegetable oil rich in linoleic acid such as sunflower or safflower oil, potassium hydroxide, phosph ric acid to neutralize the soaps. The reaction forms equal quantities of 9Z,11E-octadecadienoic acid and 10E,12Z-octadecadienoic acids.
Owner:AGRI & AGRI FOOD
Self-setting epoxy resin containing acid anhydride radicals and preparation method thereof
The invention relates to self-setting epoxy resin containing acid anhydride radicals and a preparation method thereof. The preparation method comprises the following steps: reacting 1 mol of unitary fatty acid containing conjugated double bonds with 6-10 mol of epoxy chloropropane in a proportion at a temperature of 100-120 DEG C for 2-6 h, cooling to a temperature of 20-60 DEG C, then adding 1 mol of solid sodium hydroxide and 0.001 mol of a phase transfer catalyst for a ring-closure reaction for 6-12 h, filtering and recycling excess epoxy chloropropane so as to obtain conjugated fatty acid glycidyl ester; enable 1 mol of the conjugated fatty acid glycidyl ester and 1 mol of maleic anhydride to perform a Diels-Alder diene addition reaction for 0.5-2 h at 90-110 DEG C so as to obtain the self-setting epoxy resin containing the acid anhydride radicals. Compared with a linear polymer formed in the prior art, the self-setting epoxy resin provided by the invention has mechanical properties of a thermosetting cross-linked polymer, and has higher modulus and strength after setting.
Owner:INST OF CHEM IND OF FOREST PROD CHINESE ACAD OF FORESTRY
Fatty Acid Conjugates of Quetiapine, Process for Making and Using the Same
The presently described technology provides a novel class of prodrugs of quetiapine that can be synthesized by chemically conjugating fatty acids to quetiapine. Pharmaceutical compositions and methods of synthesizing conjugates of the present technology are also provided. Methods of treating patients with the compositions of the present technology are also provided.
Owner:KEMPHARM INC
Conjugated fatty acid esters
Use of conjugated fatty acid glycerides, which are formed by converting conjugated fatty acids having conjugated double bond(s) in the molecule into glycerol esters, to more effectively exert the inherent physiological effects of the conjugated fatty acids and control the bitterness or astringency of the conjugated fatty acids, thereby making the conjugated fatty acids suitable for oral intake. These conjugated glycerides (for example, glycerides having conjugated linoleic acid in the molecule) have effects of improving lipid metabolism, preventing obesity, and preventing and treating hypertension.
Owner:YAKULT HONSHA KK
Suppression of carcinoma using high purity conjugated fatty acid
Treatment of carcinoma in a human is disclosed, including administering a therapeutically effective amount of a fatty acid having four carbons with two conjugated double bonds formed by reacting an ester of a fatty acid with a tosyl chloride or a mesyl chloride, the fatty acid having four carbon atoms such that carbon one bears one hydrogen and one hydroxyl group, carbon two bears two hydrogens, and a double bond is positioned between carbon three and four. The tosylate or mesylate of the ester of the fatty acid having the chain of four carbon atoms such that carbon one bears one hydrogen and one hydroxyl group, carbon two bears two hydrogens, and a double bond is positioned between carbon three and four is reacted with diazabicyclo-undecene. The method includes administering to a human a highly purified fatty acid in accordance with the present invention.
Owner:MATREYA
Methods for enhancing the release and absorption of water insoluble active agents
InactiveUS8524280B2Improved profilePromote absorptionBiocidePowder deliveryHydrophilic polymersActive agent
Methods for enhancing the release and / or absorption of poorly water soluble active agents are described herein. The method involves dissolving, melting, or suspending a poorly water soluble active agent in one or more molten fatty acids, conjugated fatty acids, (semi-) solid surfactants of high HLB value, and / or hydrophilic polymers. The molten active agent mixture is then suspended and homogenized in a hydrophilic or lipophilic carrier to form microparticles suspended in the hydrophilic or lipophilic carrier. The particles suspended in the hydrophilic or lipophilic carrier can be encapsulated in a hard or soft gelatin or non-gelatin capsule. It is believed that the microparticles produced by the method described above will exhibit enhanced dissolution profiles. In vitro release studies of formulations containing cilostazol and fenofibrate showed 100% dissolution of cilostazol in 15 minutes and over 90% dissolution of fenofibrate in 35 minutes.
Owner:PATHEON SOFTGELS INC
Technological method
The invention relates to a method for preparing conjugated binary unsaturated fatty acids with 12-24 carbon atoms or polyunsaturate fatty acids or salts thereof or esters thereof; the method comprises the following steps of: reacting non-conjugated free fatty acids, salts thereof or esters thereof with alkali in the existence of an alcohol solvent; and then separating conjugated fatty acids from a reaction mixture, wherein steps for separating the conjugated fatty acids from the reaction mixture comprises enabling the reaction mixture to be in contact with an aqueous solution of salts and removing a solution containing salts from the solid phase of conjugated fatty acid salts and liquid phase of at least part of solvent.
Owner:LIPID NUTRITION +1
Bifidobacterium breve and application thereof in preparation of conjugated fatty acid
ActiveCN110878273AIncrease productionImprove conversion rateBacteriaMicroorganism based processesBiotechnologyMicroorganism
The invention relates to bifidobacterium breve and an application thereof in preparation of conjugated fatty acid, belonging to the technical field of microorganisms. The invention provides bifidobacterium breve FBJCP2M1 capable of producing conjugated linoleic acid, conjugated linolenic acid and conjugated octadecatetraenoic acid, wherein the conversion rate of linoleic acid with the bifidobacterium breve FBJCP2M1 to produce the conjugated linoleic acid can reach 87.98%, and the content of the c9,t11-CLA isomer accounts for 98.38% of the content of the conjugated linoleic acid; the conversionrate of linolenic acid with the bifidobacterium breve FBJCP2M1 to produce the conjugated linolenic acid can reach 95.6%, and the content of the c9,t11,c15-CLNA isomer accounts for 95.01% of the content of the conjugated linolenic acid; and the conversion rate of octadecatetraenoic acid with the bifidobacterium breve FBJCP2M1 to produce the conjugated octadecatetraenoic acid can reach 55.86%, andthe content of c6,c9,t11,c15-CSA isomer accounts for 90.45% of the content of the conjugated octadecatetraenoic acid.
Owner:JIANGNAN UNIV +1
Methods for enhancing the release and absorption of water insoluble active agents
InactiveUS20110052682A1Improved dissolution profilePromote absorptionBiocidePowder deliveryHydrophilic polymersActive agent
Methods for enhancing the release and / or absorption of poorly water soluble active agents are described herein. The method involves dissolving, melting, or suspending a poorly water soluble active agent in one or more molten fatty acids, conjugated fatty acids, (semi-) solid surfactants of high HLB value, and / or hydrophilic polymers. The molten active agent mixture is then suspended and homogenized in a hydrophilic or lipophilic carrier to form microparticles suspended in the hydrophilic or lipophilic carrier. The particles suspended in the hydrophilic or lipophilic carrier can be encapsulated in a hard or soft gelatin or non-gelatin capsule. It is believed that the microparticles produced by the method described above will exhibit enhanced dissolution profiles. In vitro release studies of formulations containing cilostazol and fenofibrate showed 100% dissolution of cilostazol in 15 minutes and over 90% dissolution of fenofibrate in 35 minutes.
Owner:PATHEON SOFTGELS INC
Conjugated fatty acid based emulsion and methods for preparing and using same
Stable emulsions comprising as a base one or more diene conjugated fatty acids. Amino acids and other macromolecules can be used to stabilize the emulsion. The emulsion is also useful as a carrier and delivery vehicle of the macromolecules to humans or animals in need of the macromolecules. Plant oil extracts, such as conjugated linoleic acid and its acylated derivatives, are useful as the diene conjugated fatty acids that form the base of the stable emulsion. The emulsions formed are useful as nutritional or cosmetic adjuvant for oral based nutrition, skin diseases, cosmetic utility, enhancing oral nutrition, or pharmacological benefit. Methods of producing and using the emulsions are also provided.
Owner:CHANGARIS DAVID G
Synthesis of polyconjugated fatty acids
InactiveUS7091369B2High yieldBiocideFatty acid chemical modificationIodo fatty acidCombinatorial chemistry
Owner:BOARD OF TRUSTEES OPERATING MICHIGAN STATUE UNIV THE
Long-acting oxyntomodulin (OXM) hybrid peptide as well as preparation method and application thereof
ActiveCN108948212AIn line with pathological featuresEffective in treating non-alcoholic fatty liver diseasePeptide/protein ingredientsMetabolism disorderPharmacologic actionFreeze-drying
The invention relates to a class of long-acting oxyntomodulin (OXM) hybrid peptides as well as application and synthetic methods of the hybrid peptides. The preparation method comprises the followingsteps: modifying the OXM, hybridizing with a peptide sequence of Exenatide, and conjugating fatty acid chains, thereby obtaining the OXM hybrid peptides with long pharmacologic action time and excellent weight losing effects. Synthesis of target polypeptides is rapidly realized by an orthogonal protection strategy solid-phase synthesis method, and the crude product is purified and freeze-dried soas to obtain the target compound.
Owner:CHINA PHARM UNIV
Synthesis of polyconjugated fatty acids
InactiveUS20050014826A1High yieldBiocideFatty acid chemical modificationCombinatorial chemistryFatty acid
Owner:BOARD OF TRUSTEES OPERATING MICHIGAN STATUE UNIV THE
Fatty amide composition for wet use chopped strand glass fibers
InactiveCN1968906ARoof covering using tiles/slatesRoof covering using flexible materialsInterfacial bondingSaturated fatty acid
A size composition containing one or more film forming agents, at least one coupling agent, and a fatty amide lubricant synthesized from a (poly)ethylene amine and a C5-C20 unsaturated fatty acid is provided. The fatty acid is preferably a conjugated fatty acid and the (poly)ethylene amine is preferably tetraethylenepentamine. The fatty amide lubricant may be modified by maleinized rubber or carboxylated rubber. The size is advantageously applied to glass fibers such as wet use chopped strand glass and used to form roofing composites, such as shingles. The fatty amide lubricant facilitates interfacial bonding between the glass and asphalt through a vulcanizing mechanism. The unsaturation of the fatty amide modifies the surface energy of the glass fibers to make the glass more compatible with the asphalt, enhances the compatibility between the glass and the asphalt, and improves glass / asphalt interactions through the reduced interfacial tensions.
Owner:OWENS CORNING FIBERGLAS CORP
Method and composition for bacterial or fungal suppression on skin
ActiveUS20170079945A1Limited applicationSuppression problemBiocideOrganic active ingredientsMicroorganismBacteroides
The present disclosure relates to methods and compositions for suppressing the growth of microorganisms on selected areas of the skin for an extended period of time, such as one hour, twenty four hours, seventy two hours, or longer. An area of the skin is selected for the suppression of the growth of microorganisms and a microorganism growth suppressing agent is topically applied to the selected area of the skin. The microorganism growth suppressing agent may be comprised in a pharmacologically acceptable vehicle such as an emulsion or soap. The microorganism growth suppressing agent comprises free conjugated fatty acid such as conjugated linoleic acid.
Owner:CHANGARIS DAVID G
Conjugated fatty acid containing monoglycerides and process for producing them
InactiveUS7220873B2High degree of esterificationFatty acid esterificationFatty acids production/refiningIodo fatty acidMonoglyceride
This invention provides monoglycerides containing a conjugated fatty acid, and a process for producing the above described conjugated fatty acid containing monoglycerides in which all kinds of lipases can be used as catalysts.This invention relate to monoglycerides containing a conjugated fatty acid (preferably in an amount of 50% or more of fatty acids).This invention also relates to a process for producing the conjugated fatty acid containing monoglycerides, in which the conjugated fatty acid containing a free fatty acid and glycerol are subjected to the reaction of esterification, or of esterification and glycerolysis in the presence of lipase as a catalyst.
Owner:OSAKA MUNICIPAL TECHN RES INST +1
Suppression of carcinoma using high purity conjugated fatty acid
Treatment of carcinoma in a human is disclosed, including administering a therapeutically effective amount of a fatty acid having four carbons with two conjugated double bonds formed by reacting an ester of a fatty acid with a tosyl chloride or a mesyl chloride, the fatty acid having four carbon atoms such that carbon one bears one hydrogen and one hydroxyl group, carbon two bears two hydrogens, and a double bond is positioned between carbon three and four. The tosylate or mesylate of the ester of the fatty acid having the chain of four carbon atoms such that carbon one bears one hydrogen and one hydroxyl group, carbon two bears two hydrogens, and a double bond is positioned between carbon three and four is reacted with diazabicyclo-undecene. The method includes administering to a human a highly purified fatty acid in accordance with the present invention.
Owner:MATREYA
Methods for the treatment of HIV-1 related fat maldistribution, fasting hyperlipidemia and modification of adipocyte physiology
InactiveUS8093292B2Treating and preventing and normalizing lipoatrophyIncreased serum lipidsBiocidePeptide/protein ingredientsThiolSecondary hyperlipidemia
Owner:POPULATION RES
Method for producing conjugated linoleic acid glycerides
InactiveUS7179929B2Fatty oils/acids recovery from wasteFatty acid isomerisationIsomerizationGlycerol
Processes for preparing conjugated fatty acid glycerides comprising: (a) isomerizing a fatty acid lower alkyl ester corresponding to the general formula (I) in the presence of a basic catalyst at a temperature of from 100 to 160° C., to form a conjugated fatty acid lower alkyl ester:R1CO—OR2 (I)wherein R1CO represents an acyl radical having from 16 to 22 carbon atoms and at least two carbon-carbon unsaturations and R2 represents an alkyl radical having from 1 to 4 carbon atoms; and (b) transesterifying the conjugated fatty acid lower alkyl ester with glycerol to form a conjugated fatty acid glyceride, wherein a lower alkanol corresponding to the general formula R2OH is formed, wherein R2 is as defined above, and the lower alkanol is continuously removed from the transesterification reaction; are described.
Owner:COGNIS DEUT GMBH & CO KG
Conjugated fatty acid esters
InactiveUS20060257454A1Suppress bitternessSuppress astringencyBiocideDispersion deliveryFatty acid glycerol estersDouble bond
A conjugated fatty acid glyceride, which is formed by converting conjugated fatty acids having conjugated double bond(s) in the molecule into glycerol esters, to more effectively exert the inherent physiological effects of the conjugated fatty acids and control the bitterness or astringency of the conjugated fatty acids, thereby making the conjugated fatty acids suitable for oral intake. These conjugated glycerides (for example, glycerides having conjugated linoleic acid in the molecule) have effects of improving lipid metabolism, treating obesity and treating hypertension.
Owner:YAKULT HONSHA KK
Prophylactic agent of hypertension containing a conjugated fatty acid as an effective ingredient and the use thereof
InactiveUS20050002991A1Preventing and ameliorating of hypertensionBiocideOrganic chemistryDiseaseAdditive ingredient
The objects of this invention are to prevent or ameliorate hypertension to improve physical constitution and finally to provide feeds, drinks, foods, health food supplements and pharmaceuticals which may be led to the prophylaxis or amelioration of life style related diseases. A prophylactic or ameliorating agent of hypertension comprising conjugated fatty acids (e.g., conjugated linoleic acid) as effective ingredients. A feed, food and drink, and health food supplement comprising the conjugated fatty acids described above. A pharmaceutical comprising the conjugated fatty acids described above. A method for prophylactic or ameliorating of hypertension in a mammal, which comprises administering to the mammal an effective amount of a conjugated fatty acid for preventing or ameliorating of hypertension in the mammal. Use of a conjugated fatty acid for preparing a pharmaceutical for prophylactic or ameliorating of hypertension.
Owner:THE NISSHIN OILLIO GRP LTD
Lactobacillus fermentum and application thereof in preparation of conjugated fatty acid
The invention relates to Lactobacillus fermentum and application thereof in preparation of conjugated fatty acid, and belongs to the technical field of biology. The invention provides Lactobacillus fermentum CCFM1116 capable of producing conjugated linoleic acid and conjugated linolenic acid. The conversion rate of converting linoleic acid into conjugated linoleic acid by fermentation supernatantcan reach 26.19%, wherein c9, t11-CLA isomer accounts for 63.65%; and the conversion rate of converting linolenic acid into conjugated linolenic acid by fermentation supernatant can reach 41.79%, wherein c9, t11 and c15-CLANA accounts for 95.01%.
Owner:JIANGNAN UNIV
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