55 results about "Conjugated fatty acid" patented technology

The present invention provides novel dietary supplement compositions based on the use of a particular oil phase which comprises of Coenzyme Q10 and optionally other lipophilic dietary ingredients of low water solubility and a liquid mixture which comprises one or more emulsifiers, a fatty acid monoester formed between an short chain alcohol of C1 to C4 chain length and a saturated, or mono-unsaturated, or di-unsaturated (both conjugated and non-conjugated) fatty acid of C6 to C24 chain length, or medium chain mono-/di-esters, or the mixture of above. The composition is in a form of self-emulsifiable in the aqueous medium, for example, a simulated gastric fluid, which should provide a high oral bioavailability for the lipophilic dietary ingredients.

The invention provides a specific isomerase produced from lactic acid bacteria, wherein biological isomerization is employed for preparing conjugated aliphatic acid, the enzyme isomerizes 9c, 12c unsaturated fatty acid to form 9c, 11t conjugated aliphatic acid, such as 9c, 11t conjugated linolic acid, 9c, 11t conjugated linolenic acid. The invention also discloses the process for preparing conjugated aliphatic acid by conducting mutagenesis, modification, isomerase gene cloning to lactic acid bacteria, and various products of the prepared conjugated aliphatic acid and lactic acid bacteria product related with conjugated aliphatic acid.

Processes for preparing conjugated fatty acid glycerides comprising: (a) isomerizing a fatty acid lower alkyl ester corresponding to the general formula (I) in the presence of a basic catalyst at a temperature of from 100 to 160° C., to form a conjugated fatty acid lower alkyl ester:

R¹CO—OR²  (I)

wherein R¹CO represents an acyl radical having from 16 to 22 carbon atoms and at least two carbon-carbon unsaturations and R² represents an alkyl radical having from 1 to 4 carbon atoms; and (b) transesterifying the conjugated fatty acid lower alkyl ester with glycerol to form a conjugated fatty acid glyceride, wherein a lower alkanol corresponding to the general formula R²OH is formed, wherein R² is as defined above, and the lower alkanol is continuously removed from the transesterification reaction; are described.

A size composition containing one or more film forming agents, at least one coupling agent, and a fatty amide lubricant synthesized from a (poly)ethylene amine and a C₅-C₂₀ unsaturated fatty acid is provided. The fatty acid is preferably a conjugated fatty acid and the (poly)ethylene amine is preferably tetraethylenepentamine. The fatty amide lubricant may be modified by maleinized rubber or carboxylated rubber. The size is advantageously applied to glass fibers such as wet use chopped strand glass and used to form roofing composites, such as shingles. The fatty amide lubricant facilitates interfacial bonding between the glass and asphalt through a vulcanizing mechanism. The unsaturation of the fatty amide modifies the surface energy of the glass fibers to make the glass more compatible with the asphalt, enhances the compatibility between the glass and the asphalt, and improves glass/asphalt interactions through the reduced interfacial tensions.

The present invention relates to methods for large-scale production of conjugated fatty acids, especially conjugated linoleic acids in plants. More specifically, the present invention relates to genes identified from Calendula officinalis coding for a conjugase and its related enzyme, a .DELTA.12 desaturase, and utilization of them for large scale production of conjugated linoleic and linolenic acids in plants. The genes encoding a conjugase can introduce two conjugated double bonds at 8 and 10 positions, and a .DELTA.12 desaturase can introduce a double bond at 12 position of acyl chains. The constructs containing these genes can be transferred to plants with different substrate profiles, which allows for the production of conjugated linoleic acids (18:2, .DELTA.8, .DELTA.10) and linolenic acids (18:3, .DELTA.8, .DELTA.10, .DELTA.12) in plant seeds on a commercial scale.

The present invention relates to a fermented food and process for producing the same, in which the food contains a sufficient amount of conjugated fatty acid and is excellent in digestivity and absorbability, physiological effects, safety, sensory properties, and the like. The fermented food is obtained by adding a conjugated fatty acid in the form of a glyceride to a fermentation medium either before or after the fermentation by the fermenting bacterium, and the final fermented food product contains such conjugated fatty acid in the form of a glyceride. The conjugated fatty acid of the glyceride type is a glyceride derivative containing a fatty acid having conjugated double bonds (a conjugated fatty acid) as its constituent fatty acid, and sustains many of useful physiological activities of the conjugated fatty acid while coping with the inhibitory action of free fatty acids to the fermenting bacterium.

The invention relates to self-setting epoxy resin containing acid anhydride radicals and a preparation method thereof. The preparation method comprises the following steps: reacting 1 mol of unitary fatty acid containing conjugated double bonds with 6-10 mol of epoxy chloropropane in a proportion at a temperature of 100-120 DEG C for 2-6 h, cooling to a temperature of 20-60 DEG C, then adding 1 mol of solid sodium hydroxide and 0.001 mol of a phase transfer catalyst for a ring-closure reaction for 6-12 h, filtering and recycling excess epoxy chloropropane so as to obtain conjugated fatty acid glycidyl ester; enable 1 mol of the conjugated fatty acid glycidyl ester and 1 mol of maleic anhydride to perform a Diels-Alder diene addition reaction for 0.5-2 h at 90-110 DEG C so as to obtain the self-setting epoxy resin containing the acid anhydride radicals. Compared with a linear polymer formed in the prior art, the self-setting epoxy resin provided by the invention has mechanical properties of a thermosetting cross-linked polymer, and has higher modulus and strength after setting.

Use of conjugated fatty acid glycerides, which are formed by converting conjugated fatty acids having conjugated double bond(s) in the molecule into glycerol esters, to more effectively exert the inherent physiological effects of the conjugated fatty acids and control the bitterness or astringency of the conjugated fatty acids, thereby making the conjugated fatty acids suitable for oral intake. These conjugated glycerides (for example, glycerides having conjugated linoleic acid in the molecule) have effects of improving lipid metabolism, preventing obesity, and preventing and treating hypertension.

The invention relates to a method for preparing conjugated binary unsaturated fatty acids with 12-24 carbon atoms or polyunsaturate fatty acids or salts thereof or esters thereof; the method comprises the following steps of: reacting non-conjugated free fatty acids, salts thereof or esters thereof with alkali in the existence of an alcohol solvent; and then separating conjugated fatty acids from a reaction mixture, wherein steps for separating the conjugated fatty acids from the reaction mixture comprises enabling the reaction mixture to be in contact with an aqueous solution of salts and removing a solution containing salts from the solid phase of conjugated fatty acid salts and liquid phase of at least part of solvent.

The invention relates to bifidobacterium breve and an application thereof in preparation of conjugated fatty acid, belonging to the technical field of microorganisms. The invention provides bifidobacterium breve FBJCP2M1 capable of producing conjugated linoleic acid, conjugated linolenic acid and conjugated octadecatetraenoic acid, wherein the conversion rate of linoleic acid with the bifidobacterium breve FBJCP2M1 to produce the conjugated linoleic acid can reach 87.98%, and the content of the c9,t11-CLA isomer accounts for 98.38% of the content of the conjugated linoleic acid; the conversionrate of linolenic acid with the bifidobacterium breve FBJCP2M1 to produce the conjugated linolenic acid can reach 95.6%, and the content of the c9,t11,c15-CLNA isomer accounts for 95.01% of the content of the conjugated linolenic acid; and the conversion rate of octadecatetraenoic acid with the bifidobacterium breve FBJCP2M1 to produce the conjugated octadecatetraenoic acid can reach 55.86%, andthe content of c6,c9,t11,c15-CSA isomer accounts for 90.45% of the content of the conjugated octadecatetraenoic acid.

Methods for enhancing the release and/or absorption of poorly water soluble active agents are described herein. The method involves dissolving, melting, or suspending a poorly water soluble active agent in one or more molten fatty acids, conjugated fatty acids, (semi-) solid surfactants of high HLB value, and/or hydrophilic polymers. The molten active agent mixture is then suspended and homogenized in a hydrophilic or lipophilic carrier to form microparticles suspended in the hydrophilic or lipophilic carrier. The particles suspended in the hydrophilic or lipophilic carrier can be encapsulated in a hard or soft gelatin or non-gelatin capsule. It is believed that the microparticles produced by the method described above will exhibit enhanced dissolution profiles. In vitro release studies of formulations containing cilostazol and fenofibrate showed 100% dissolution of cilostazol in 15 minutes and over 90% dissolution of fenofibrate in 35 minutes.

Stable emulsions comprising as a base one or more diene conjugated fatty acids. Amino acids and other macromolecules can be used to stabilize the emulsion. The emulsion is also useful as a carrier and delivery vehicle of the macromolecules to humans or animals in need of the macromolecules. Plant oil extracts, such as conjugated linoleic acid and its acylated derivatives, are useful as the diene conjugated fatty acids that form the base of the stable emulsion. The emulsions formed are useful as nutritional or cosmetic adjuvant for oral based nutrition, skin diseases, cosmetic utility, enhancing oral nutrition, or pharmacological benefit. Methods of producing and using the emulsions are also provided.

The present invention relates to fatty acids. In particular, the present invention provides polyconjugated fatty acids, and methods of their synthesis and their use.

The present disclosure relates to methods and compositions for suppressing the growth of microorganisms on selected areas of the skin for an extended period of time, such as one hour, twenty four hours, seventy two hours, or longer. An area of the skin is selected for the suppression of the growth of microorganisms and a microorganism growth suppressing agent is topically applied to the selected area of the skin. The microorganism growth suppressing agent may be comprised in a pharmacologically acceptable vehicle such as an emulsion or soap. The microorganism growth suppressing agent comprises free conjugated fatty acid such as conjugated linoleic acid.

This invention provides monoglycerides containing a conjugated fatty acid, and a process for producing the above described conjugated fatty acid containing monoglycerides in which all kinds of lipases can be used as catalysts.

This invention relate to monoglycerides containing a conjugated fatty acid (preferably in an amount of 50% or more of fatty acids).

This invention also relates to a process for producing the conjugated fatty acid containing monoglycerides, in which the conjugated fatty acid containing a free fatty acid and glycerol are subjected to the reaction of esterification, or of esterification and glycerolysis in the presence of lipase as a catalyst.

The objects of this invention are to prevent or ameliorate hypertension to improve physical constitution and finally to provide feeds, drinks, foods, health food supplements and pharmaceuticals which may be led to the prophylaxis or amelioration of life style related diseases. A prophylactic or ameliorating agent of hypertension comprising conjugated fatty acids (e.g., conjugated linoleic acid) as effective ingredients. A feed, food and drink, and health food supplement comprising the conjugated fatty acids described above. A pharmaceutical comprising the conjugated fatty acids described above. A method for prophylactic or ameliorating of hypertension in a mammal, which comprises administering to the mammal an effective amount of a conjugated fatty acid for preventing or ameliorating of hypertension in the mammal. Use of a conjugated fatty acid for preparing a pharmaceutical for prophylactic or ameliorating of hypertension.

The invention relates to Lactobacillus fermentum and application thereof in preparation of conjugated fatty acid, and belongs to the technical field of biology. The invention provides Lactobacillus fermentum CCFM1116 capable of producing conjugated linoleic acid and conjugated linolenic acid. The conversion rate of converting linoleic acid into conjugated linoleic acid by fermentation supernatantcan reach 26.19%, wherein c9, t11-CLA isomer accounts for 63.65%; and the conversion rate of converting linolenic acid into conjugated linolenic acid by fermentation supernatant can reach 41.79%, wherein c9, t11 and c15-CLANA accounts for 95.01%.