The invention discloses a pyramidal micro-truss sandwich plate bearing and thermal protection integrated structure with flow channels, which includes at least one structural unit, the structural unit includes an upper panel, a lower panel and a core, and the core includes multiple A micro-truss unit cell, the micro-truss unit cell is formed by connecting the tops of two pyramid-shaped lattice unit cells, and the pyramid-shaped lattice unit cell is a pyramid formed by four rods with circular cross-sections type structure, the left and right ends of the upper panel are respectively provided with flow channel wall plates extending towards the direction of the core. The present invention can improve the bearing capacity, defect resistance and impact protection capacity of the present invention at the same time. The flow channel is arranged near the heat source to further improve the heat dissipation effect. By adjusting the flow rate of the cooling liquid, the temperature of the lower panel can be efficiently controlled in one In an appropriate range, it is more conducive to controlling the sealing, reducing the amount of fluid used to reduce the overall weight coefficient of the structure, and the best performance can be obtained by adjusting the size of each part.