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Soluble glycosaminoglycanases and methods of preparing and using soluble glycosaminogly ycanases

The invention relates to the discovery of novel soluble neutral active Hyaluronidase Glycoproteins (sHASEGPs), methods of manufacture, and their use to facilitate administration of other molecules or to alleviate glycosaminoglycan associated pathologies. Minimally active polypeptide domains of the soluble, neutral active sHASEGP domains are described that include asparagine-linked sugar moieties required for a functional neutral active hyaluronidase domain. Included are modified amino-terminal leader peptides that enhance secretion of sHASEGP. The invention further comprises sialated and pegylated forms of a recombinant sHASEGP to enhance stability and serum pharmacokinetics over naturally occurring slaughterhouse enzymes. Further described are suitable formulations of a substantially purified recombinant sHASEGP glycoprotein derived from a eukaryotic cell that generate the proper glycosylation required for its optimal activity.
Owner:HALOZYME

Soluble glycosaminoglycanases and methods of preparing and using soluble glycosaminoglycanases

The invention relates to the discovery of novel soluble neutral active Hyaluronidase Glycoproteins (sHASEGPs), methods of manufacture, and their use to facilitate administration of other molecules or to alleviate glycosaminoglycan associated pathologies. Minimally active polypeptide domains of the soluble, neutral active sHASEGP domains are described that include asparagine-linked sugar moieties required for a functional neutral active hyaluronidase domain. Included are modified amino-terminal leader peptides that enhance secretion of sHASEGP. The invention further comprises sialated and pegylated forms of a recombinant sHASEGP to enhance stability and serum pharmacokinetics over naturally occurring slaughterhouse enzymes. Further described are suitable formulations of a substantially purified recombinant sHASEGP glycoprotein derived from a eukaryotic cell that generate the proper glycosylation required for its optimal activity.
Owner:HALOZYME

Soluble Glycosaminoglycanases and Methods of Preparing and Using Soluble Glycosaminoglycanases

The invention relates to the discovery of novel soluble neutral active Hyaluronidase Glycoproteins (sHASEGPs), methods of manufacture, and their use to facilitate administration of other molecules or to alleviate glycosaminoglycan associated pathologies. Minimally active polypeptide domains of the soluble, neutral active sHASEGP domains are described that include asparagine-linked sugar moieties required for a functional neutral active hyaluronidase domain. Included are modified amino-terminal leader peptides that enhance secretion of sHASEGP. The invention further comprises sialated and pegylated forms of a recombinant sHASEGP to enhance stability and serum pharmacokinetics over naturally occurring slaughterhouse enzymes. Further described are suitable formulations of a substantially purified recombinant sHASEGP glycoprotein derived from a eukaryotic cell that generate the proper glycosylation required for its optimal activity.
Owner:HALOZYME +6

Wireless transceiver, circuit module, and method for setting channel access time

A method for calculating a channel access time necessary for ensuring a desired throughput for a wireless transceiver for performing channel access using priority queuing system, the method comprising: calculating a channel access time necessary for accomplishing a desired throughput with respect to the or each one of a plurality of data flows stored in a buffer corresponding to apriority queue; and setting as a common channel access time for transmitting the data flow associated with the priority queue the largest value of the calculated channel access times.
Owner:NOKIA CORP

Polyurethane composition and polishing pad

A polyurethane composition containing solid beads dispersed therein, characterized in that the polyurethane is a microcellular polyurethane foam and the composition has a storage modulus of elasticity at 40° C. of 270 MPa or more as measured by means of a dynamic elasticity measuring device: and a polyurethane composition containing solid beads dispersed therein, characterized in that the solid beads are capable of swelling with or being soluble in an aqueous medium. The former composition has excellent flattening capability, and the latter composition can provide a polished surface which combines good flatness and good uniformity and can also reduce scratches on the surface.
Owner:ROHM & HAAS ELECTRONICS MATERIALS CMP HLDG INC

Transparent display device and transparent display panel

A transparent display device includes at least a first transparent display panel and a second transparent display panel, each of which has transparent regions and display regions. The arrangements of the transparent regions and display regions of the first transparent display panel and the second transparent display panel are opposite to each other. The transparent display device can apply a high transparency display mode or a lower transparency display mode by arranging the relative position of the first and second transparent display panels. In the lower transparency display mode, the first and second transparent display panels are at least partial overlapped with each other so as to display clear image with high definition.
Owner:AU OPTRONICS CORP

Organic conductive polymer composition, transparent conductive film, transparent conductor, and input device and process for producing the same

The present invention relates to organic conductive polymer compositions adapted to produce touch panel input devices that hardly undergo resistance degradation even after prolonged and repeated usages, and represent remarkably improved reliability and lifetime in particular. The organic conductive polymer compositions according to the present invention comprise a thiophene derivative polymer, a water-soluble organic compound (except for nitrogen-containing compounds), and a dopant, wherein the thiophene derivative polymer is expressed by the formula (1).
Owner:FUJITSU LTD

Preserved pharmaceutical formulations

The present invention is directed to the use of benzethonium chloride, alone or in combination with phenoxyethanol or phenyl ethyl alcohol, to provide anti-microbial activity in pharmaceutical compositions. The present invention also provides methods of using benzethonium chloride, alone or in combination with phenoxyethanol or phenyl ethyl alcohol, to inhibit microbial growth in pharmaceutical compositions.
Owner:AVENTISUB LLC

Stable aspirin-containing preparations for external use

InactiveUS6268355B1Superior in stability and transdermal absorptionPromote absorptionBiocideNervous disorderOrganic acidChemistry
External preparations containing Aspirin which are stored for a long term and superior in dermal absorbability.The preparations are prepared by mixing Aspirin together with at least one substance selected from an ester of an organic acid ester having 2 to 20 carbon atoms, a glycerol fatty acid ester, silicon oil, hydrocarbon oil and crotamiton.
Owner:TEIKOKU SEIYAKU KK TEIKOKU SEIYAKU CO LTD

Soluble glycosaminoglycanases and methods of preparing and using soluble glycosaminoglycanases

The invention relates to the discovery of novel soluble neutral active Hyaluronidase Glycoproteins (sHASEGPs), methods of manufacture, and their use to facilitate administration of other molecules or to alleviate glycosaminoglycan associated pathologies. Minimally active polypeptide domains of the soluble, neutral active sHASEGP domains are described that include asparagine-linked sugar moieties required for a functional neutral active hyaluronidase domain. Included are modified amino-terminal leader peptides that enhance secretion of sHASEGP. The invention further comprises sialated and pegylated form of a recombinant sHASEGP to enhance stability and serum pharmacokinetics over naturally occurring slaughterhouse enzymes. Further described are suitable formulations of a substantially purified recombinant sHASEGP glycoprotein derived from a eukaryotic cell that generate the proper glycosylation required for its optimal activity.
Owner:HALOZYME

Light emitting device

There is provided a light emitting device which enables a color display with good color balance. A triplet compound is used for a light emitting layer of an EL element that emits red color, and a singlet compound is used for a light emitting layer of an EL element that emits green color and a light emitting layer of an EL element that emits blue color. Thus, an operation voltage of the EL element emitting red color may be made the same as the EL element emitting green color and the EL element emitting blue color. Accordingly, the color display with good color balance can be realized.
Owner:SEMICON ENERGY LAB CO LTD

Image sensing apparatus and black level controlling method thereof

An image sensing apparatus and a black level controlling method thereof are provided. The black level controlling method includes following steps. A conversion relationship between analog gain values and offset values is provided. An analog gain value is converted into an analog offset value by using the conversion relationship between analog gain values and offset values. Whether to adjust the analog offset value is decided according to a first optical black data corresponding to a first part of optical black pixels. A digital data offset value is calculated according to a data corresponding a second part of optical black pixels.
Owner:NOVATEK MICROELECTRONICS CORP

Content delivery system and method

This invention relates to an apparatus and method to provide event notifications to a user. More specifically, this invention is related to a content delivery system which provides event notifications to the user according to the user's current location and the content in the user's electronic device. Since the content, such as play count, number of songs, etc., may indicate the user's preference about some specific artists, this invention is particularly related to an intelligent content delivery system adapted to provide event notification to the user according to the user's preference. The content delivery system includes an event searching unit, a playback information retrieving unit and an information processing unit which is configured to determine whether to provide and display at least a portion of said first content information by analyzing a plurality of factors and managing said first content and second content information. The factors include but not limited to, whether the event location is within a predetermined distance from the current location, future event occurrence, and event ticket availability.
Owner:ALPINE ELECTRONICS INC

Ink jet recording sheet

An ink recording sheet having a stable ink receiving layer which eliminates problems of cracks generated on the ink receiving layer, and which is also excellent in glossiness, ink absorptivity, image quality, and long-term preservability. The ink jet recording sheet includes a supporting medium, and an ink receiving layer including an inorganic fine particle, a cationic polymer, and a binder. The ink receiving layer is disposed on the supporting medium, wherein the average primary particle size of the inorganic fine particle is 30 nm or less, and the cationic polymer is a polymer (A) including: at least one structural unit (a1) expressed by a following general formula (1) or (2): wherein X represents an acid residue; and at least one structural unit (a2) expressed by a following general formula (3): wherein R1 represents a C1-18 alkyl group, C1-18 alkoxy group, C6-12 aryl group, or benzyl group.
Owner:OJI PAPER CO LTD

Image display device and image display method

Provided are an image display device and an image display method capable of reducing the number of signal lines connected between a driver IC and a liquid crystal display portion and of displaying a preferable image. A liquid crystal display portion is divided into 16 division groups in a scanning direction. In order to scan the liquid crystal display portion, a common scanning signal line which is a scanning signal output line of a scanning signal line driver circuit is connected with a selective scanning signal line of each of the 16 division groups during switching for each of the groups. The common scanning signal line is commonly used among the plurality of selective scanning signal lines, so the number of wirings to be connected in the driver IC can be reduced.
Owner:SEIKO INSTR INC

Failure detecting device for a load driving system

A failure detecting device for a load driving system including an upper arm driving means connected between a positive electrode of a direct current power source and one end of a load and a lower arm driving means connected between a negative electrode of the direct current power source and the other end of the load for on / off-controlling the respective driving means to control a voltage or an electric current to be supplied to the load, the failure detecting device including: resistor elements respectively connected in parallel to the upper arm driving means and the lower arm driving means; and a load condition anomaly detecting means for detecting an anomaly of the load driving system including the load or wiring to the load by observing terminal voltage of one or both of the load terminals.
Owner:MITSUBISHI ELECTRIC CORP

Method of manufacturing organic electroluminescent device

A method of manufacturing an organic electroluminescent device is provided. First, a substrate and an anode on the substrate are provided, and then, an organic electroluminescent material layer is formed on the anode. Next, a multi-layer transparent cathode is formed on the organic electroluminescent layer. The step of forming the multi-layer transparent cathode comprises performing a co-evaporation process to form a doped buffer layer comprising electron transport materials and dopant so as to distribute the dopant uniformly in the electron transport materials.
Owner:INNOLUX CORP

Band-pass filter module and module substrate

A bandpass filter module includes a mounting board and a BPF chip mounted on a surface thereof. The BPF chip includes three or more resonators; a first-stage resonator located closest to an input terminal, a final-stage resonator located closest to an output terminal, and a middle-stage resonator connected between the first-stage and the final-stage resonators and located in a chip middle zone. The mounting board includes an area overlapping with the chip middle zone, viewed in plan, defining a ground-free space in which no ground electrode is disposed. The ground-free space is formed at least from the surface of the mounting board to a depth position at which a topmost internal wiring layer is located. The middle-stage resonator is prevented from being coupled to ground electrodes on the mounting board and from a lower Q-value and increased insertion loss.
Owner:TDK CORPARATION

Switch circuit and composite high frequency elements

A switch circuit for switching the connection of the receiving or transmitting circuits of two communication systems to an antenna circuit, which comprises first and second switch means having two switching elements, the first switch means comprising a first inductance element between a port connected to the antenna circuit and a port connected to the second switch means; the second switch means comprising a second inductance element between a port connected to the first switch means and a port connected to a receiving circuit of a first communication system, and a transmission line constituting the first inductance element having a lower characteristic impedance than that of a transmission line constituting the second inductance element.
Owner:HITACHI METALS LTD

Functional composite film and quantum dot film

A functional composite film includes one or more combinations of an inorganic layer and an organic layer as underlying base of the inorganic layer on a support, and having the outermost surface with an organic layer thereon, where the organic layer on the outermost surface is formed using an ultraviolet-curable urethane polymer having a weight-average molecular weight of 5,000 to 30,000 and a double bond equivalent of 300 g / mol or more, which has a urethane polymer as the main chain and a side chain having a (meth)acryloyl group at a terminal; a curable urethane polyester; and at least one phosphoric acid compound containing two or less (meth)acryloyl groups and / or a silane coupling agent containing one (meth)acryloyl group, and a quantum dot film using the same. High adhesiveness is obtained between the organic layer and the inorganic layer, and when a quantum dot layer or the like is laminated thereon.
Owner:FUJIFILM CORP
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