54results about How to "Reduce cell damage" patented technology

A modified annexin protein, preferably annexin V, is used to prevent thrombosis without increasing hemorrhage. Annexin binds to phosphatidylserine on the outer surface of cell membranes, thereby preventing binding of the prothrombinase complex necessary for thrombus formation. It does not, however, affect platelet aggregation necessary for hemostasis. The modified annexin molecule can be a homodimer of annexin, an annexin molecule coupled to one or more polyethylene glycol chains, or an annexin molecule coupled to another protein. By increasing the molecular weight of annexin, the modified annexin is made to remain in circulation for sufficient time to provide a sustained therapeutic effect.

The present invention includes a harvesting and irrigation device, a method and a kit for the collection of viable fat cells and / or adipose tissue with decreased handing and improved yield and viability.

The disclosed item is a composition comprising catechins and sialic acid to provide an effective prevention and treatment for Helicobacter Pylori infection. This composition inhibits growth of Helicobacter pylori, and can increase the antioxidant activity of gastric mucosal cells through reducing the production of O2.−, H2O2 and NO, and decreasing the expression of inducible nitric oxide synthase (iNOS) in cells. The apoptotic damage of stomach caused by Helicobacter pylori was decreased through up-regulation of autophagy to enhance the defensive ability of gastric epithelial cells toward Helicobacter pylori. Therefore the composition can be used in the treatment or prevention on damages caused by Helicobacter pylori infection.

Modified annexin proteins, including a homodimer of human annexin V, are provided. Methods for their use, such as to prevent thrombosis without increasing hemorrhage and to attenuate ischemia-reperfusion injury (IPI), are also provided. The modified annexins bind phosphatidylserine (PS) on cell surfaces, thereby preventing the assembly of the prothromkinase complex. The modified annexin decreases the binding of leukocytes and platelets during post-ischemic reperfusion, thereby restoring microvascular blood flow and decreasing organ damage.

An ascorbic acid-based composition and related method for the treatment of aging or photo-damaged skin is disclosed. The composition includes water and ascorbic acid, at least a portion of which has generally been pretreated by being dissolved under relatively high temperature and concentration conditions. The composition typically includes at least about 5.0% (w / v) ascorbic acid and may advantageously be formulated to have a pH above 3.5. Generally, the composition also includes non-toxic zinc salt, tyrosine compound, and / or pharmaceutically acceptable carrier. In addition, the composition may include an anti-inflammatory compound, such as aminosugar and / or sulfur-containing anti-inflammatory compound. The topical composition may be in the form of a serum, a hydrophilic lotion, an ointment, a cream, or a gel.

The invention provides a novel method of dissociating anchorage independent and dependent cell aggregates. The invention also includes the cells resulting from the methods of the invention and the use of the cells in various applications requiring the generation of a single cell suspension.

Modified annexin proteins, including a homodimer of human annexin V, are provided. Methods for their use, such as to prevent thrombosis without increasing hemorrhage, enhancing the survivability of platelets during storage or transfusion and to attenuate ischemia-reperfusion injury (IPI), are also provided. The modified annexins bind phosphatidylserine (PS) on cell surfaces, thereby preventing the assembly of the prothromkinase complex. The modified annexin decreases the binding of leukocytes and platelets during post-ischemic reperfusion, thereby restoring microvascular blood flow and decreasing organ damage. In addition, the modified annexin prevents lipid loss from platelets during storage.

Sperm, oocyte, and embryo survival and function is improved in vivo or in vitro by the use of a polysaccharide containing arabinose, galactose and / or hexuronic acid. In particular, a nonspermicidal lubricant containing such a polysaccharide (e.g., gum arabic, pectin, or galacturonic acid) increases the fertilization potential of the sperm during coitus, artificial insemination or sperm collection. Similarly, a freezing medium containing a polysaccharide containing arabinose, galactose and / or hexuronic acid enhances sperm, oocyte, or embryo viability.

Provided herein are compounds of Formula I, compositions comprising an effective amount of a compound of Formula I, and methods for preventing, reducing or treating retinal ganglion cell damage comprising administering an effective amount of a purine derivative to a subject in need thereof.

The present invention directs to a centrifugal filtration device, for separating living cells, including a spindle (28), a rotary arm (211) which is connected vertically to the spindle (28) and rotates as the spindle rotates, and a microporous membrane filter (31) which is mounted on the rotary arm (211). The microporous membrane filter (31) includes an inlet (311), an outlet (312), a front cavity (313) having the inlet (311) formed thereon, a rear cavity (314) having the outlet (312) formed thereon, and a filter membrane (315) arranged between the front cavity and the rear cavity; the diameter of each filter pore formed in the filter membrane is smaller than that of the cell which needs to be separated. The present invention also discloses a cell separation system.

The invention relates to a kind of near-infrared iodofluoroboron dipyrrole photosensitizer and a preparation method thereof. It is synthesized by Knoevenagel condensation reaction under the catalysis of p-toluenesulfonic acid and piperidine by using terindaldehyde and iodo-BODIPY derivatives. Both the absorption and emission wavelengths are above 680nm, and can penetrate deeply into biological tissues under the irradiation of near-infrared light. It can be used as a superior near-infrared photosensitizer for photodynamic therapy of tumors and cancers. In addition, this type of compound has excellent photophysical properties such as high molar extinction coefficient and good photostability, and has potential application value in laser dyes, biomedicine and other fields.

Topical, UBIQUINOL supplement compositions useful for treating skin by: reducing oxidative stress, adjunctively restoring “local” UBIQUINOL levels, revitalizing aged and / or U.V. damaged skin and regulating immune responses, including responses to inflammatory challenges; comprising: stabilized UBIQUINOL supplement, an emulsion of polydimethylsiloxane in a nonionic surfactant and skin penetrants.

The present invention relates to a one-photon and / or two-photon fluorescent probe for selectively detecting hydrogen sulfide in the human body using a compound including an α,β-unsaturated carbonyl group and an acedan (2-acyl-6-dimethyl-amino-naphthalene) fluorescent material; to an imaging method of hydrogen sulfide in cells using the same; and to a manufacturing method of the fluorescent probe. More specifically, in the fluorescent probe of the present invention, the α,β-unsaturated carbonyl group of the compound selectively binds to hydrogen sulfide, inducing an increase in fluorescence of the acedan fluorescent material. The fluorescent probe according to the present invention can be conveniently synthesized, enables two-photon excitation, and corresponds to a small-molecule probe having stability and low toxicity in the body. In addition, the fluorescent probe according to the present invention can exhibit a fluorescent change by selectively reacting with hydrogen sulfide, thereby imaging the distribution of hydrogen sulfide in cells or tissues, and thus can be useful for a composition for imaging and an imaging method.

The present invention relates to cryopreserved cell cultures, methods for cryopreserving cells and methods for conducting cellular assays on such cells. A cryopreserved cell culture of the invention comprises a container having at least a surface which is coated with poly-lysine and frozen cells supported on the surface.

The invention provides a freezing thermostatic chamber, an air-cooled refrigerator and a temperature control method of the air-cooled refrigerator. The freezing thermostatic chamber comprises an inner container which forms a storage cavity, a casing arranged on the outer side of the inner container and a cold storage material arranged between the inner container and the casing and attached to the inner container; cooling air channels are formed between the inner container and the casing and between the cold storage material and the casing; an air inlet and an air outlet which communicate with the cooling air channels are formed in the casing; a quick-cooling air inlet is formed in the side, facing the air inlet, of the inner container; and an air door is arranged at the quick-cooling air inlet. With the freezing thermostatic chamber and the air-cooled refrigerator, quick cooling inside the freezing thermostatic chamber is realized, the temperature fluctuation is reduced, the loss of nutrients of food is reduced, and the taste and the freshness of the food are kept.

The present invention provides novel nitrones, their preparation and use. The novel compounds have the following formula: I The compounds of the present invention have strong antioxidative activity, and are thrombolytic. These compounds can be used to treat and / or prevent diseases caused by overproduction of free radicals and / or formation of thrombus.

An ascorbic acid-based composition and related method for the treatment of aging, photo-damaged or inflamed skin is disclosed. The composition includes water and ascorbic acid, at least a portion of which has generally been pretreated by being dissolved under relatively high temperature and concentration conditions. The composition typically includes at least about 5.0% (w / v) ascorbic acid formulated to have a pH above 3.5. 10 to 50% of the ascorbic acid is pretreated ascorbic acid. The composition may also include a non-toxic zinc salt, a tyrosine compound, and / or pharmaceutically acceptable carrier. The composition may include an anti-inflammatory compound, such as aminosugar and / or sulfur-containing anti-inflammatory compound. Embodiments containing an aminosugar such as glucosamine are further useful for treating rosacea and other inflammatory skin ailments. The composition may be administered in a variety of forms suitable for topical application on skin.

The present invention relates to a method for preparing a garlic-fermented composition and a garlic-fermented composition prepared by the method, and the purpose of the present invention is to provide a garlic-fermented composition which is easy to take, has no side effect, and improves excellent pharmacological and physiological efficacies of garlic. To achieve this, the method for preparing a garlic-fermented composition according to an aspect of the present invention, comprises: a first fermentation step of mixing garlic, water, and a ferment strain, followed by fermentation, thereby decomposing and converting sugars and proteins of the garlic; and a second fermentation step of additionally supplying a carbon source to a filtrate obtained through solid-liquid separation of the fermented product, followed by fermentation, thereby removing ammonia of the filtrate and decomposing and converting the additionally supplied carbon source.

A device for cardiocirculatory assistance constituting a pump for a blood flow includes a body, a pair of covers, and a pair of membranes. The device is provided with a circuit for the passage of a gas or gaseous fluid alternatively under pressure and depressurization so that a reciprocating pumping motion of the membranes is established.

The invention discloses a whitening anti-aging facial cream which is prepared from the following raw materials: milk thistle, dendrobium nobile, linden blossom, cranberry, waste hair, shell powder, freeze-dried apple powder, allantoin, tween, span, betaine, soybean lecithin, octadecylamine, cholesterol, vaseline, anhydrous lanolin, hexadecanol, glyceryl monostearate, synanthrin, triethanolamine, glycerin, seabuckthorn seed oil, polyethylene glycol-20-cetearyl alcohol ether, polyoxyethylene hydrogenated castor oil, vitamin e, phenoxyethanol, methyl p-hydroxybenzoate and water. The facial cream disclosed by the invention has the functions of effectively removing dirt, supplementing moisture, providing nutrition to skin, delaying aging, reducing the aging speed of free radicals and recovering whiteness and vigor.

The invention discloses a moisturizing anti-wrinkle cream, which is prepared from the following raw materials in parts by weight: 1-2 parts of lubrajel, 2-3 parts of sodium pyrrolidonecarboxylate, 1-2 parts of D-panthenol, 2-3 parts of jojoba oil, 0.2-0.3 part of ethylparaben, 0.7-1 part of isopropyl myristate, 3-5 parts of propylene glycol, 13-16 parts of lyophilized watermelon skin powder, 4-5 parts of sweet almond oil, 6-8 parts of beeswax, 4-5 parts of cinnamyl alcohol, 10-13 parts of fermented soybean meal, 20-25 parts of milk thistle, 33-37 parts of dendrobium flowers, 10-13 parts of linden blossom, 16-20 parts of cranberry, 2-3 parts of myristic acid, 3-4 parts of glycerin polyoxyethylene poly propylene ether oxygen oleic acid ester, 40-50 parts of waste hair, 13-15 parts of shell powder, 1-2 parts of synanthrin and 50-60 parts of water. The moisturizing anti-wrinkle cream has the effects of whitening the skin, removing freckles, removing winkles, tendering the skin, increasing the skin glossiness and elasticity, nourishing the skin and delaying senescence, and is mild, free of irritation and free of a toxic or side effect.

Sperm, oocyte, and embryo survival and function is improved in vivo or in vitro by the use of a polysaccharide containing arabinose, galactose and / or hexuronic acid. In particular, a nonspermicidal lubricant containing such a polysaccharide (e.g., gum arabic, pectin, or galacturonic acid) increases the fertilization potential of the sperm during coitus, artificial insemination or sperm collection. Similarly, a freezing medium containing a polysaccharide containing arabinose, galactose and / or hexuronic acid enhances sperm, oocyte, or embryo viability.

The present application relates to the field of medicine. The present application relates to an isolated Saposhnikovia divaricata polysaccharide and use thereof in the manufacture of a medicament for treating diabetes mellitus or hyperlipoidemia. In particular, the present application relates to an isolated Saposhnikovia divaricata polysaccharide comprising L-arabinose, D-galacturonic acid, D-mannose, D-glucose and D-galactose, wherein the molar ratio of the L-arabinose: D-galacturonic acid: D-mannose: D-glucose: D-galactose is 1-15:1-10:1-10:10-40:1-15, preferably 1-5:5-10:1-5:20-25:1-5.

The present invention concerns a neuroglobin agonist for use in the treatment or prevention of a mitochondrial disease associated with respiratory chain complex I (RCCI) deficiency and / or respiratory chain complex III (RCCIII) deficiency.

Modified annexin proteins, including a homodimer of human annexin V, are provided. Methods for their use, such as to prevent thrombosis without increasing hemorrhage and to attenuate ischemia-reperfusion injury (IPI), are also provided. The modified annexins bind phosphatidylserine (PS) on cell surfaces, thereby preventing the assembly of the prothromkinase complex. The modified annexin decreases the binding of leukocytes and platelets during post-ischemic reperfusion, thereby restoring microvascular blood flow and decreasing organ damage.

The present invention provides a method for cell rejuvenation, including contacting cells with a composition containing a Rosa roxburghii fruit extract obtained by extraction of a Rosa roxburghii fruit using water, alcohol, or mixtures of water and alcohol as solvents. Said extract improves DNA repair, reduces cell damage caused by oxidative stress or inflammation, maintains the normal functions of genes, proteins, and mitochondria, facilitates telomerase reaction and reduces telomere damage by chemicals or UV radiation, thereby improving cell rejuvenation.

Dietary fibre compositions composed of 48-90% w / w glucomannan, 5-20% w / w xanthan gum and 5-30% w / w alginate in combination with metformin, sitagliptin or a mixture thereof for the treatment of metabolic disease are disclosed.