The invention discloses medicine with traditional Chinese medicine as raw materials for treating chronic nephritis, and belongs to the technical field of traditional Chinese medicine. The medicine is composed of angelica sinensis, atractylodes macrocephala koidz, astragalus, poria cocos, Chinese yam, achyranthes bidentata, semen plantaginis, spreading hedyotis herbs, indian iphigenia bulbs, diversifolious patrinia roots, honeysuckle, euphorbia humifusa, herba artemisiae scopariae, polygonum cuspidatum, red peony roots, ramulus euonyrni, fructus lycii, cornus officinalis, cassia twigs, nutmeg, fructus amomi and semen cassia according to a certain weight proportion. The medicine herbs are used jointly and have the functions of rising yang, tonifying spleen, tonifying the kidney, resolving dampness, inducing diuresis to alleviate edema and nourishing liver and kidney, the medicine functions achieve a synergistic effect, lasting drug efficacy continuously acts on a focus, and the medicine has excellent treatment effect on chronic nephritis.