The present invention discloses a method for calculating a maximum movement distance of collapse in a karst region. The method is characterized in comprising the following steps: a, calculating the position of the crack at the rear end of the collapse, the position of the front end of the collapse, the average length of the collapse and the width of the collapse, calculating the collapse area A, and calculating the collapse volume V through V=0.146A1.332; and b, determining the maximum movement distance Lmax of the collapse according to the elevation difference H and the collapse volume V, when the collapse volume V>100000m3, performing calculation through Lmax=H/10 0.109 log V+0.17, and when the collapse volume V<100000m3, performing calculation through Lmax=H/10 0.109 log V+0.22. According to the technical scheme of the present invention, the maximum movement distance of the collapse in the karst area can be accurately calculated, the hazards caused by collapse risks and collapses can be effectively avoided, and the effectiveness of disaster prevention is greatly improved.