The invention belongs to the technical field of geotechnical engineering, and discloses a comprehensive prevention and control system applied to a gravel soil side slope. According to the comprehensive prevention and control system, the good slope anti-seepage effect is achieved by burying drainage blind pipes and rapid drainage pipes in a slope surface layer soil body, arranging an intercepting ditch at the top of the slope, arranging a drainage channel at the foot of the slope and performing planting and greening on the slope surface, and the influence of surface water infiltration such as rainfall on the slope stability is reduced; after spring type spiral steel bars are put into pile holes, concrete doped with an expanding agent is poured into the pile holes to form miniature anti-slide piles, prestressed anchor cables are arranged to improve the shear strength of the side slope, and the stability among a potential sliding surface upper landslide mass, a potential sliding belt anda lower stable soil mass is enhanced; a plain concrete retaining wall is arranged at the foot of the slope to support the side slope, and a deep drainage pipe is drilled in the concentrated seepage area to effectively cut off the concentrated seepage, and water is collected and guided out of the slope; and finally, the anti-seepage drainage and reinforcement effects on the side slope are remarkable, and compared with traditional electro-osmosis drainage, energy consumption is reduced, economic benefits are remarkable, and operability is high.