The invention provides an emergency medicine used for treating snakebite, and a preparation method thereof. The emergency medicine is a traditional Chinese medicine composition comprising components of: bezoar, sheep horn, artificial musk, buffalo horn condensed powder, scorpion, centipede, periostracum cicadae, lumbricus, silkworm larva, dragon's bones, pearl, realgar, wenchow turmeric root tuber, cinnabar, golden thread, Baikal skullcap root, amur corktree bark, cape jasmine, honeysuckle flower, florists dendranthema, rehmannia dride rhizome, angelica archang lica, weeping forsythia fruit, borneol, and paris polyphylla smith. The medicine can be prepared into pills, powders, tablets and capsules. The medicine provided by the invention has effects against various thanatophidia bites, and has substantial effects for patients with organic damages and critical conditions caused by malpractice and delayed treatments.