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33 results about "Particle agglutination" patented technology

Agglutination is the clumping together of particles which forms non-dissolvable or what is called as insoluble aggregates. The common substances used in the PAT are latex particles, preserved blood cells from mammals or birds, colloidal particles, and gelatine beads.

Method and device for ultrasound assisted particle agglutination assay

Ultrasound-assisted particle agglutination assay methods and apparatuses are described based on first providing a standing wave ultrasound field at a resonance frequency of a test liquid in a resonator cell containing microparticles covered with a binding agent with high affinity to an analyte sought to be detected by the assay test. Formation of the specifically-bound and nonspecifically-bound aggregates of these microparticles is then followed by effective stirring of the liquid with swept-frequency sonication causing disintegration of nonspecifically-bound aggregates and leaving specifically-bound aggregates in place for further detection and measurement. The methods and devices of the invention allow significant improvement in the sensitivity and specificity of agglutination tests and are advantageously applicable to detecting various proteins, DNA, RNA and other biologically active substances. Specific examples are provided.
Owner:ALLIED INNOVATIVE SYST

Homogeneous double receptor agglutination assay for immunosuppressant drugs

A homogeneous, non-competitive, double receptor agglutination assay for measuring immunosuppressant drugs is described. The assay employs at least two receptors wherein each receptor is specific for a separate binding site on the drug and wherein each receptor is bound to a detection particle. The immunosuppressant drug binds to the receptors and causes particle agglutination, which can be measured and correlated with the presence or amount of immunosuppressant drug in a sample.
Owner:SIGLER GERALD F +5

Particles for immunoassays and methods for treating the same

A method of treating particles to be used in immunoassays reduces interference in particle agglutination assays. For particles having covalently bound antibodies and residual NHS-ester or sNHS-ester groups on the surface, the reactive esters are treated with an aqueous mixture containing an amine compound of formula (I):H2N—R—X  (I). The moiety —X is —NH2, —OH, or —CO2CH2CH3; and R is an alkyl group or an alkyl ether group. When —X is —NH2 or —CO2CH2CH3, R contains from 1 to 20 carbon atoms; and when —X is —OH, R contains from 4 to 20 carbon atoms.
Owner:ROCHE DIAGNOSTICS OPERATIONS INC

Latex reagent for adiponectin analysis and method of adiponectin analysis

ActiveUS20070037207A1Rapidly and conveniently performBiological testingLatex particleAgglutination
A latex reagent for analyzing adiponectin, comprising a suspension of latex particles carrying a substance which specifically binds to adiponectin, is disclosed. Further, a method for analyzing adiponectin, comprising (1) obtaining a biological liquid possibly containing adiponectin, and (2) bringing the biological liquid, while maintaining the state in which the biological liquid is obtained, into contact with a suspension of latex particles carrying a substance which specifically binds to adiponectin, and optically analyzing a degree of latex-particles-agglutination, is disclosed. According to the latex reagent and the method for analyzing adiponectin, a predilution or pretreatment of the biological liquid to be analyzed is not necessary. Further, the analysis can be performed rapidly and conveniently, and facilities therefor are not limited.
Owner:MITSUBISHI CHEM MEDIENCE +1

Particle agglutination detection method and device

A method for the detection and / or visualization of particle agglutination, comprising: placing a volume of a suspension of the particles on a filter, the filter being constructed so as to permit passage of individual particles; placing a volume of a solution or suspension containing an agglutinating agent at the location of the particle suspension; optionally placing a wash solution at the location of the agglutinating agent; and observing the surface at the location for the presence of particles, such presence indicating that agglutination of the particles occurred. There is also provided a method for detection of agglutination reactions in general and hemagglutination reactions, such as used in blood grouping and cross-matching, in particular. The method is comprised of successive vertical additions of whole blood, blood grouping reagent and wash to a filter. In case of hemagglutination a colored, preferably red or reddish dot becomes visible after washing. A device and a kit based on the invention is also claimed and facilitates blood grouping and matching in non-laboratory environment without the need for laboratory instruments.
Owner:INVERNESS MEDICAL SWITZERLAND GMBH

Inert carrier indirect agglutination test detection system and application thereof

ActiveCN111537712ANo self-condensationSelf-condensation does not occurBiological material analysisDepsipeptidesSerum/Whole bloodAntigen
The invention discloses an inert carrier indirect agglutination test detection system and application thereof. The system comprises inert carrier bacteria S9 and a complex S9-P which is shown and expressed on the surface of the inert carrier bacteria S9 and carries a P-antibody factor. The system only carries the P-antibody factor, is single in component and specific in targeting, generates macroscopic positive particle agglutination reaction with whole blood or serum of chicken infected by pullorum disease and salmonella typhimurium under a certain concentration condition, and does not generate non-specific cross agglutination reaction with chicken-derived serum and whole blood of different backgrounds infected by non-pullorum disease and salmonella typhimurium. The S9-P is based on a glass plate agglutination reaction operation platform. The S9-P is simple and convenient to operate, sensitive and rapid in reaction, macroscopic in agglutination reaction particles and clear and easy inresult judgment, tests and result judgment are completed within two minutes, and the S9-P is suitable for targeted specific detection of pullorum disease and salmonella gallinarum infection in chicken flocks and has a good application prospect in on-site monitoring and diagnosis of the chicken flocks.
Owner:YANGZHOU UNIV

Latex particles for measuring particle agglutination

Latex particles for a particle agglutination assay, with which it is possible to carry out high-sensitivity assay while highly suppressing a non-specific reaction are disclosed. The latex particles being obtained by emulsion polymerization with a polymerizable monomer having a phenyl group, and a polymerizable monomer having a phenyl group and a sulfonate in an aqueous medium including a nonionic surfactant at a concentration of 0.005 to 0.02 wt % based on the aqueous medium, the latex particles having an average particle size of 0.005 to 1.0 μm.
Owner:SEKISUI MEDICAL CO LTD

Blood serum or blood plasma diluting solution applied to detection method of trace gelatin particle agglutinated HIV-1 (Human Immunodeficiency Virus-1) recent infection

InactiveCN102608312ARealize independent productionRespond effectivelyMaterial analysisMedicineBovine serum albumin
The invention provides a blood serum or blood plasma sample diluting solution applied to a method for detecting trace gelatin particle agglutinated HIV-1 (Human Immunodeficiency Virus-1) recent infection, belonging to the field of a biological technology. The invention particularly provides a reagent applied to detecting the HIV-1 recent infection. The diluting solution is prepared from a buffering solution, TritonX100 with the concentration of 30%, NaN3 and bovine serum albumin by mixing according to a ratio. The diluting solution disclosed by the invention can completely replace a DilsimTM11 diluting solution and can be used for a detection method of the trace gelatin particle agglutinated HIV-1 recent infection.
Owner:李洪

Use of superhydrophobic surfaces for liquid agglutination assays

This invention relates to the use of thermodynamically incompatible surfaces in agglutination assays for the express purpose of using the sample as a key component of the detection instrument. Specifically, the invention relates to formation of a lense and a virtual container for rapid mixing via thermal energy by a sample liquid disposed on a superhydrophobic surfaces, and a subsequent specific analyte or overall protein concentration assay using particles agglutination for use in the industrial, environmental, and clinical laboratory test fields.
Owner:THE ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIV OF ARIZONA

Insoluble carrier particle nephelometric immunoassay reagent

InactiveCN1443309AStable absorbanceAgglutination StabilizationBiological testingAntigenTricine
Turbidimetric immunoassay of insoluble carrier particles that can inhibit the agglutination reaction of insoluble carrier particles such as latex by inhibiting the effect of plasma components that affect the measured value, stabilize the agglutination reaction, stabilize the absorbance of the reaction solution, and obtain accurate measurement results A reagent for measurement, a kit for insoluble carrier particle turbidimetric immunoassay, and a method for insoluble carrier particle turbidimetric immunoassay using the reagent or kit. In the presence or absence of a buffer containing a compound containing the following groups in the molecule, such as broad bean pyrimidine glucoside, tricoflavone, etc., the insoluble carrier particles are loaded with antibodies or antigens, and then, in the presence of the above buffer , the insoluble carrier particle suspension sensitive to the antibody or antigen is in contact with the test body, and an immunoagglutination reaction occurs, and the concentration produced is measured through the agglutination reaction of the insoluble carrier particles, and the antigen or antibody in the test body is quantified. (In the formula, R1, R2, and R3 can be the same or different, and represent a hydrogen atom, a hydroxyalkyl group, etc.)
Owner:KYOWA MEDEX CO LTD +1

Gelatin particle-agglutination detection reagent kit suitable for 1type duck hepatitis virus antibody and its uses

The invention belongs to the bird immunology technology area, it concretely relates to a kit of acceptable for the one type duck hepatitis virus antibody emulsion agglutination and the application of testing one type duck hepatitis virus antibody emulsion agglutination. The kit of this invention contains box body and core reagent in the box body, positive check sample, negative check sample, sample cell, scale sample sucker and the carrier of observed result. The characteristic is that core reagent is latex antigen from sublimating e duck hepatitis virus AV2111 and inactivating one type duck hepatitis virus sensitization polystyrene latex, the positive check sample is one type duck hepatitis virus antiserum, the negative check sample is the green duck of a day old of no one type duck hepatitis mother source antibody. The carrier is the paper characteristic latex agglutination card of having hollowness. The invention also discloses the preparation method and application of this kit. The kit has the significance merit of high specificity, high sensitivity, handy operation, and quickly diagnose.
Owner:HUAZHONG AGRI UNIV

Aqueous pharmaceutical suspensions containing rebamipide and manufacturing process thereof

The invention provides a rebamipide-containing aqueous pharmaceutical suspension which can be prepared by a simple process and keep the dispersed fine-particle state of rebamipide stable without having the fine particle agglutinated. The rebamipide-containing aqueous pharmaceutical suspension of the invention is prepared by mixing polyvinyl alcohol and additionally a sodium salt compound with rebamipide.
Owner:OTSUKA PHARM CO LTD

Particle agglutination-evaluating container

A particle agglutination-evaluating container for immunological analysis, based on an agglutinate formed in an agglutination reaction between an antibody- or antigen-containing sample and agglutination particles, includes a transparent container body having a bottom face including a sloping bottom face and a raised bottom face extended in a horizontal direction at the top of the sloping bottom face to form an obtuse angle with the sloping bottom face, and a fluidal separation layer containing insoluble particles which are filled in the container body and where the agglutination particles are separated according to the agglutination degree, wherein agglutination is evaluated by observation from the bottom of the container body, where the agglutination reaction is judged positive when the agglutination particles are observed through the raised bottom face, negative when observed at the bottom end of the sloping bottom face, and weakly positive when observed in the middle of the sloping bottom face.
Owner:BECKMAN COULTER INC

Quinidine conjugates and their use in immunoassays

This invention relates to quinidine derivatives and immunogenic conjugates and reporter conjugates prepared therefrom. The immunogenic conjugates and reporter conjugates are useful for eliciting antibodies and for performing immunoassays for quinidine. A particle agglutination immunoassay for quinidine is also provided.
Owner:DADE BEHRING

Regenerated particle aggregate, process for producing regenerated particle aggregate, regenerated-particle-aggregate-containing paper containing regenerated particle aggregate as internal additive, an

The present invention relates to a regeneration particle aggregate, a method thereof for making the regeneration particle aggregate, a regeneration particle aggregate integrated paper which is integrated with the regeneration particle aggregate at the inner side, and a printing used coated paper which is coated with the regeneration particle aggregate. The aim of the invention is to provide various papers which use the recyclable regeneration particle aggregate to make a contribution to environment protection. In the making process of various papers, the regeneration particle aggregate is at least contained to be used as an added filling agent, coating used paint, etc. The regeneration particle aggregate uses the voided naps discharged from the wastepaper treating process as a principal raw material. The regeneration particle aggregate is obtained mainly through the processes of dewatering process, drying process, burning process and crushing process.
Owner:DAIO PAPER CORP

Particle agglutination in a tip

An apparatus and a related method for performing particle agglutination reactions in at least one disposable probe tip are disclosed. The at least one probe tip includes a sample cavity for sample acquisition, at least one flanking cavity for the capture of particles by centrifugation or other means, a transition zone for the mixing of the sample with reagents for agglutination and a detection zone for the optical detection of particle agglutination. A mechanism may be attached to the probe tip for the controlled movement of fluids through the internal volume of the probe tip. The probe tip is particularly useful for the automation of high-throughput agglutination-type assays.
Owner:ORTHO-CLINICAL DIAGNOSTICS

Mixing method and mixing apparatus for particle agglutination

A mixing method for particle agglutination includes the following steps of: dropping testing materials into an accommodating recess at one end of a channel structure; pressing a flexible layer on the other end of the channel structure; and releasing the flexible layer to an initial position after pressing the flexible layer such that a negative pressure is generated by an air chamber that is covered by the flexible layer and draws the testing materials that are in the accommodating recess to move toward the air chamber along a diverging channel of the channel structure. The testing materials are mixed with each other in the diverging channel, in which the depth of the diverging channel is gradually increased from the accommodating recess to the air chamber.
Owner:DELTA ELECTRONICS INC

Inert carrier indirect agglutination test detection system and its application

ActiveCN111537712BAvoid non-specific cross-agglutination reactionsPotential application value is goodBiological material analysisDepsipeptidesSerum/Whole bloodAntigen
The invention discloses an inert carrier indirect agglutination test detection system and its application. The indirect agglutination test detection system comprises an inert carrier bacterium S9 and a complex S9-P expressing and carrying P antigen factors on its surface. The inert carrier indirect agglutination test detection system only carries the P antigen factor, has a single component, and is specifically targeted. It will produce a positive particle agglutination reaction visible to the naked eye under certain concentration conditions with the whole blood or serum of chickens infected with pullorum and Salmonella gallinarum typhi. However, non-specific cross-agglutination reactions did not occur in chicken-derived serum and whole blood with different backgrounds of non-pulmonary pullorum and Salmonella gallinarum infection. The S9‑P is based on the glass plate agglutination reaction operation platform, which is easy to operate, sensitive and fast, the agglutination reaction particles are visible to the naked eye, and the results are clear and easy to judge. The test and result judgment can be completed within two minutes. The S9‑P is suitable for chickens in chicken flocks The target-specific detection of pullorum and Salmonella gallinarum typhi infection has a good application prospect in the field monitoring and diagnosis of chicken flocks.
Owner:YANGZHOU UNIV
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