The invention discloses a locking self-sealing dry quick joint. The locking self-sealing dry quick joint comprises a dry quick male joint and a dry quick female joint; the dry quick male joint comprises a male joint shell, a male joint valve base, a guide spring bushing, a spring, a slide valve element and a spiral guide groove; and the dry quick female joint comprises a female joint shell, a valve element support base, a fixed valve element, a slide valve base, a guide bushing, a spring bushing, a spring, a front end cover, a cam and an operation hand wheel. The locking self-sealing dry quickjoint realizes connection and disconnection through the female joint axially rotated in and out of the male joint, so that the medium leakage quantity in the connection and disconnection process during fluid conveying is reduced, and the purposes of environmental protection and conservation are achieved; and the locking self-sealing dry quick joint reduces internal friction of a mechanical structure through the cam and the spiral guide groove structure, is lower in operation driving force, saves both time and cost, optimally designs the flowing speed, and guarantees lower flow and pressure loss.