The invention discloses a self-oscillation DC-DC circuit. The source electrode of a switch MOS tube M1 is connected with a DC power supply Vin, the drain electrode of the switch MOS tube M1 and the drain electrode of a switch MOS tube M2 are connected with one end of an energy storing inductor L1, the grid electrode of the switch MOS tube M1 and the grid electrode of the switch MOS tube M2 are connected to two output ends of a switch driver respectively, the source electrode of the switch MOS tube M2 is connected to the ground, the other end of the energy storing inductor L1 is connected with the anode of an energy storing capacitor C1 and a load, the cathode of the energy storing capacitor C1 is connected to the ground, the two input ends of a triangular wave generation circuit are connected to the two ends of the energy storing inductor L1 in parallel, the output end of the triangular wave generation circuit is connected with the source signal input end of a comparison circuit, two window signal input ends of the comparison circuit are connected to the window voltage, and the output end of the comparison circuit is connected with the input end of the switch driver. The self-oscillation DC-DC circuit is characterized by simple structure, self oscillation, free of an amplification circuit, rapid response, low power consumption, low electromagnetic interference and the like.