The invention provides an automatic machining clamp with a multi-directional adjustment function, and belongs to the field of machining equipment. The automatic machining clamp comprises a first bracket, a second bracket, an air cylinder, a first clamping block, a second clamping block, a first motor, a second motor, a lead screw and supporting legs; and the supporting legs are arranged on the lower portion of the first bracket, the second motor is arranged in the middle of the first bracket, the second motor is fixedly connected with the lead screw, the second bracket is arranged on the upperportion of the first bracket, the first clamping block and the second clamping block are mounted on the second bracket, the air cylinder is arranged on the left side of the second bracket, the air cylinder is fixedly connected with the first clamping block, and the first motor is arranged on the right side of the second bracket. The automatic machining clamp is simple in structure, stable in operation and easy to maintain; workpieces are automatically clamped, the clamping speed is high, and the efficiency of workpiece mounting is high; the workpiece mounting position can be adjusted in the multiple directions, machining and positioning are facilitated, and the production efficiency is improved; and the multiple clamping blocks are arranged, and thus the automatic machining clamp is applied to clamping of the workpieces with different shapes, and is high in applicability and convenient to use.