41results about How to "Improve the ability to resist external pathogen infection" patented technology

The invention relates to the field of a protein and particularly relates to a milk-derived bioactive polypeptide QEPVL with in-vitro antioxidant activity and body immunity promoting activity, wherein an amino acid sequence of the bioactive polypeptide QEPVL is Gln-Glu-Pro-Val-Leu. Through an in-vitro antioxidant test and an in-vitro immunity promoting test, the polypeptide QEPVL is proved to have relatively good antioxidant biological activity and immunity improving function; on one hand, free radicals in the body can be removed to reduce the harm on the human body caused by the free radicals; on the other hand, according to the bioactive polypeptide QEPVL, the immunity of the body can be further enhanced and the multiplication capacity of lymphocytes in vitro can be promoted, thereby improving the ability of the body to resist infections of external pathogens and reducing the incidence rate of the body without causing immunological rejections. The bioactive polypeptide QEPVL has great significance for the development of milk products, healthcare products and medicines with the antioxidant function and the immunity enhancement.

Provided is a milk-derived biologically active polypeptide having an amino acid sequence of QEPV, which has in-vitro antioxidation activity and enhances immunity of human body. The polypeptide has good biological antioxidation activity, and has the function of enhancing immunity of cells and human body.

The invention discloses a dietetic therapy formula for resisting to inflammation, improving cardiovascular and cerebrovascular diseases and regulating blood sugar and in-vivo qi and blood. The dietetic therapy formula adopts the raw material selection and components as follows: 76.8-96 kg of barley grass powder, 0.8-1 kg of wheat low-poly titanium, 1.6-2 kg of chlorella pyrenoidosa and 0.8-1 kg of chitosan oligosaccharide. The dietetic therapy formula for resisting to inflammation, improving cardiovascular and cerebrovascular diseases and regulating blood sugar and in-vivo qi and blood, which is provided by the invention, is prepared by stirring and mixing the quantitative barley grass powder, wheat low-poly titanium, chlorella pyrenoidosa and chitosan oligosaccharide, and vitamin C, beta-carotene, an antioxidant enzyme, total glutamic acid, CGF and other substances contained in the dietetic therapy formula take a synergistic effect, the pH value of blood can be balanced, the body recovery of post-operation crowds is accelerated, the immunity of organisms is improved, the hematopoietic function is enhanced, qi and blood of a human body are effectively regulated, the blood sugar can be reduced, blood fat can be reduced, hypertension can be reduced, nutritional ingredients of the body can be supplemented, the cell regeneration working capacity is promoted, and the dietetic therapy formula is suitable for rehabilitation and conditioning of people with cardiovascular and cerebrovascular diseases.

The present invention proposes a kind of ointment that can improve leukocyte content, and is prepared from the following raw materials by weight: 10-20 parts of carboxymethyl polysaccharide, 12-17 parts of colostrum basic protein, and 5-parts of wheat oligopeptide 10 parts, 35‑40 parts of mulberry, 5‑10 parts of longan meat, 10‑20 parts of coix seed, 20‑25 parts of sealwort, 10‑20 parts of yam, 20‑25 parts of jujube and 15‑20 parts of honey. The ointment of the invention has the effects of enhancing the body's immunity, increasing the leukocyte content in the blood, improving the body's ability to withstand hypoxia, and the like. It has definite curative effect on the treatment of diseases such as low immune function and leukopenia. The invention has wide sources of raw materials, simple preparation method, and the prepared ointment has a good effect of improving immunity, can increase the content of white blood cells, stimulate the proliferation of lymphocytes, reduce the incidence of body diseases, and has broad application prospects.

The invention relates to the field of protein, in particular to a bioactive peptide SGSAAWDDSAGGAGGQGLRVTAL as well as a preparation method and application thereof, and the amino acid sequence of thebioactive peptide SGSAAWDDSAGGAGGQGLRVTAL is Ser-Gly-Ser-Ala-Ala-Trp-Asp-Asp-Ser-Ala-Gly-Gly-Ala-Gly-Gly-Gln-Gly-Leu-Arg-Val-Thr-Ala-Leu. An in-vitro immunoregulation function experiment shows that the bioactive peptide SGSAAWDDSAGGAGGQGLRVTAL has a relatively good immunoregulation function. The invention further discloses a preparation method of the bioactive peptide SGSAAWDDSAGGAGGQGLRVTAL. Thebioactive peptide SGSAAWDDSAGGAGGQGLRVTAL can promote macrophage activation, release cytokines and improve the external pathogen infection resistance of an organism, has a remarkable promoting effecton the neutral red phagocytosis capacity of in-vitro macrophages under the condition that inflammation occurs, can reduce the incidence rate of the organism, improves the life quality, and has very important significance in developing food, health care products and medicines with immunoregulation functions.

Provided is a milk-derived biologically active polypeptide having an amino acid sequence of QEPVL, which has in-vitro antioxidation activity and promotes immune activity of human body. In-vitro antioxidation and in-vitro immunity promotion experiments prove that the peptide has good biological antioxidation activity, and has the function of enhancing immunity.

The present invention relates to the field of proteins, in particular to a bioactive peptide KQSLPPGLAVKDLK and its preparation method and application. The amino acid sequence of the bioactive peptide KQSLPPGLAVKDLK is Lys‑Gln‑Ser‑Leu‑Pro‑Pro‑Pro‑Gly‑Leu‑Ala‑Val‑Lys ‑Asp‑Leu‑Lys. The in vitro immune function regulation experiment proved that the biologically active peptide KQSLPPGLAVKDLK has a good immune regulation function. The biologically active peptide KQSLPPGLAVKDLK of the present invention has the ability to enhance the in vitro proliferation of macrophages and lymphocytes, improve the ability of the body to resist external pathogen infection, reduce the incidence of the body, improve the quality of life, and is useful for the development of food and health products with immune regulation functions. and drugs are of great importance.

The invention relates to the field of proteins, in particular to bioactive polypeptide VAVVKKGSNFQ as well as a preparation method and application thereof. An amino acid sequence of the bioactive polypeptide VAVVKKGSNFQ is Val-Ala-Val-Val-Lys-Lys-Gly-Ser-Asn-Phe-Gln. In-vitro antioxidant experiments and in-vitro immune function promotion experiments prove that the polypeptide VAVVKKGSNFQ has better antioxidant biological activity and an immune regulation function; on the one hand, the polypeptide VAVVKKGSNFQ has the better antioxidant activity, thus being capable of removing free radicals in a human body and further improving the quality of life; on the other hand, the bioactive polypeptide VAVVKKGSNFQ can enhance the in vitro proliferative capacity of lymphocytes and macrophages and promote the increment of nitrogen monoxide induction amount of the macrophages, thus improving the external pathogen infection resistance of the organism and reducing the morbidity of the organism; therefore, the bioactive polypeptide VAVVKKGSNFQ has a very important significance for developing food, health care products and medicines which have the immune regulation function and the antioxidant function.

Provided is a milk-derived biologically active polypeptide having an amino acid sequence of DELQ, which has in-vitro antioxidation activity and promotes immune activity of human body. In-vitro antioxidation and in-vitro immunity promotion experiments prove that the peptide has good biological antioxidation activity, and has the function of enhancing cellular immunity.

Provided is a polypeptide, the amino acid sequence of which is SLPQ. The polypeptide is prepared by fermented skimmed milk by Lactobacillus helveticus. The polypeptide can enhance immunity of a body, so also provided are food, health products and medicines comprising the polypeptide.

The invention relates to the field of proteins, in particular to a biologically active peptide RLAFIAHPKLG and a preparation method and application thereof. The amino acid sequence of the biologically active peptide RAFIAHPKLG is Arg-Leu-Ala-Phe-Ile-Ala-His-Pro-Lys-Leu-Gly . Through in vitro immunomodulatory function experiments, it was found that the biologically active peptide RLAFIAHPKLG has a good immunomodulatory function. The bioactive peptide RLAFIAHPKLG of the present invention has the ability to enhance the in vitro proliferation ability of lymphocytes, can promote macrophages to secrete cytokines, improve the body's ability to resist infection by external pathogens, reduce the body morbidity rate, improve the quality of life, and has immunomodulatory effects on development Functional foods, health products and medicines are of great significance.

The present invention relates to the field of proteins, in particular to a bioactive peptide LECVEPNCRSKR and its preparation method and application. The amino acid sequence of the bioactive peptide LECVEPNCRSKR is Leu-Glu-Cys-Val-Glu-Pro-Asn-Cys-Arg-Ser-Lys ‑Arg. Through the in vitro immune function regulation experiments, it was verified that the biologically active peptide LECVEPNCRSKR has a good immune regulation function. The biologically active peptide LECVEPNCRSKR of the present invention has the ability to increase the induction of macrophage nitric oxide under a certain concentration, can effectively inhibit the inflammation caused by oxidation in the body, inhibit the overexpression of inflammatory factors, and improve the body's resistance to external pathogens The ability to infect, reduce the morbidity of the body, and improve the quality of life are of great significance to the development of foods, health products and medicines with immune regulation functions.

Provided is a milk-derived biologically active polypeptide having an amino acid sequence of LPLP, which has in-vitro antioxidation activity and enhances immunity of human body. The polypeptide has good biological antioxidation activity, and has the function of enhancing immunity of cells and human body.

The invention provides a nutritious food with a function of boosting immunity and a preparation method of the nutritious food. The nutritious food disclosed by the invention comprises the following components in percentage by weight: 5%-10% of wheat oligopeptides powder, 0.08%-0.12% of zinc gluconate, 0.03%-0.05% of vitamin B2, 12%-16% of lentinus edodes powder, 10%-14% of whole milk powder, 8%-12% of isolated soy protein powder, 7%-11% of oat powder, and 40%-60% of an auxiliary material. The nutritious food provided by the invention is reasonable in component matching, is capable of providing various nutritional ingredients such as sufficient protein, amino acids, mineral substances, vitamins for a human body, simultaneously has the efficacies of improving the immunity of the organisms and reducing the disease risk of the human body, is especially suitable for being used as a breakfast assist or substitute food; and in addition, the nutritious food disclosed by the invention is good in taste and flavor, convenient to eat, easy to absorb by the human body, and wide in market prospect, and meets the consumption needs of modern society people.

The present invention relates to the field of proteins, in particular to a bioactive peptide GGYGSGGGSGGYGSRRF and its preparation method and application. The amino acid sequence of the bioactive peptide GGYGSGGGSGGYGSRRF is Gly-Gly-Tyr-Gly-Ser-Gly-Gly-Gly-Ser-Gly-Gly ‑Tyr‑Gly‑Ser‑Arg‑Arg‑Phe. After the verification experiment of immune regulation function in vitro, it was found that the biologically active peptide GGYGSGGGSGGYGSRRF has a good immune regulation function. The biologically active peptide GGYGSGGGSGGYGSRRF of the present invention can significantly enhance the in vitro proliferation ability of macrophages, can effectively inhibit inflammation caused by oxidation, has a good immune regulation effect, can improve the body's ability to resist external pathogen infection, and reduce the body's morbidity , improving the quality of life is of great significance to the development of food, health products and medicines with immune regulation function.

The invention discloses bioactive peptides with APN inhibitory effect, the amino acid sequences of which are respectively Cys-Asn-Arg, Cys-Asp-Arg and Gly-Glu-Phe. The invention proves that the bioactive peptides Cys-Asn-Arg, Cys-Asp-Arg and Gly-Glu-Phe have APN inhibitory effect and anti-tumor potential activity through structure screening and activity measurement. At the same time, the bioactive peptides Cys‑Asn‑Arg, Cys‑Asp‑Arg and Gly‑Glu‑Phe exist stably under in vivo digestion conditions, can be fully absorbed and utilized by the body to exert their biological activity, and have anti-tumor functions for development Food, health products and medicines are of great significance.

The present invention relates to the field of proteins, in particular to a bioactive peptide ASEPPVLDVKRPFLC and its preparation method and application. The amino acid sequence of the bioactive peptide ASEPPVLDVKRPFLC is Ala‑Ser‑Glu‑Pro‑Pro‑Val‑Leu‑Asp‑Val‑Lys‑Arg ‑Pro‑Phe‑Leu‑Cys. The in vitro immune function regulation experiment verified that the biologically active peptide ASEPPVLDVKRPFLC has a good immune regulation function. The biologically active peptide ASEPPVLDVKRPFLC of the present invention can effectively inhibit the inflammation caused by oxidation in the body, promote the secretion of cytokines by macrophages, improve its function in the resting state of normal macrophages, improve the body's ability to resist external pathogen infection, reduce It is of great significance to develop food, health care products and medicines with immune regulation function to reduce the incidence of the body and improve the quality of life.

The present invention relates to the field of protein, in particular to a biologically active peptide having an amino acid structure VVRKPLNKEGKKP and its preparation method and application. The amino acid sequence of the biologically active peptide VVRKPLNKEGKKP is shown in SEQ ID NO: 1, and the amino acid sequence of the biologically active peptide VVRKPLNKEGKKPR is shown in SEQ ID NO: 2 shown. In vitro immunoregulatory function experiments have proved that the bioactive peptides VVRKPLNKEGKKP and VVRKPLNKEGKKPR have good immune regulatory functions. The VVRKPLNKEGKKP and VVRKPLNKEGKKPR of the present invention have the ability to promote the increase in the induction of macrophage nitric oxide under certain concentration conditions, thereby improving the body's ability to resist external pathogen infection, reducing the incidence of the body, and at the same time promoting the proliferation of macrophages in vitro and exerting their full potential. The immune function of the body is of great significance to the development of food, health products and medicines with immune regulation function.

The present invention relates to the field of proteins, in particular to a bioactive peptide IAHPKLGKRIR and its preparation method and application. The amino acid sequence of the bioactive peptide IAHPKLGKRIR is Ile‑Ala‑His‑Pro‑Lys‑Leu‑Gly‑Lys‑Arg‑Ile‑Arg . In vitro immune function regulation experiments proved that the biologically active peptide IAHPKLGKRIR has a good immune regulation function. The biologically active peptide IAHPKLGKRIR of the present invention can promote the proliferation ability of lymphocytes in vitro, improve the immunity of the human body, and at the same time have a significant promotion effect on the ability of macrophages to phagocytize neutral red in vitro, improve the body's ability to resist external pathogen infection, reduce the body's It is of great significance to develop food, health care products and medicines with immune regulation function and improve the quality of life.