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50results about How to "Not easy to leave" patented technology

Eye movement interaction method, system and device based on eye movement tracking technology

ActiveCN111949131ASolve the problem of not being able to accurately locate the targetImprove operational efficiencyInput/output for user-computer interactionSound input/outputOptometryEye tracking on the ISS
The invention belongs to the technical field of eye movement tracking, and discloses an eye movement interaction method, system and device based on eye movement tracking technology, and the method comprises the steps: setting a passive adsorption gaze cursor or an eye movement interaction intention of a sensing area and predicting an active adsorption gaze cursor to select a target; setting corresponding sensing areas, namely effective clicking areas, for different targets, when the cursor makes contact with or covers the sensing area of a certain target, whether eye movement behaviors such aseye tremor exists or not, detecting whether the glancing distance exceeds a threshold value or not at the same time, and absorbing or highlighting then the target object. A machine learning algorithmis adopted to train the eye movement behavior data of the user, the data is filtered, processed and analyzed, an eye movement behavior rule is trained, and a subjective consciousness eye movement interaction intention model of the user is obtained. Through the method, the stability and accuracy in the eye movement interaction process are improved, and the user experience of eye movement interaction is improved.
Owner:陈涛

Automatic wire threader of wire electric discharge machining device

An automatic wire threader comprises a jet nozzle (20) configured from first and second divided nozzles (91, 92). The jet nozzle (20) is attachable to a jet stream nozzle (46). The automatic wire threader further comprises a first finger (61) for supporting the first divided nozzle (91), a second finger (62) for supporting the second divided nozzle (92), and an opening and closing unit (70) for opening and closing the first and second fingers (61, 62) to unite or separate the first and second divided nozzles (91, 92) and simultaneously couple or detach the jet nozzle (20) to or from the jet stream nozzle (46). An annular groove (25) is formed in the inner peripheral surface (24) of the jet nozzle (20), and an annular protrusion (48) that is fitted into the annular groove (25) is formed on the outer peripheral surface of the jet stream nozzle (46). The first and second divided nozzles (91, 92) comprise divided surfaces (23U, 23B), respectively. A valley-shaped groove is formed in the first divided surface and a mountain-shaped protrusion that is fitted into the valley-shaped groove is formed on the second divided surface.
Owner:SODICK CO LTD

Television ferrule

The invention discloses a television ferrule, which comprises a locking nut and a plugging main body, wherein the plugging main body comprises a plugging shell with a television copper core jack, a television plug inner core and a television plug ferrule; the television plug inner core is arranged in the plugging shell; the television plug ferrule is plugged into the television plug inner core; a taper plugging part is arranged at the front end of the plugging shell; a copper core through hole which is communicated with the television copper core jack in the plugging shell is formed in the central axis of the taper plugging part; an inverted triangle shielded wire mounting and locking convex ring is arranged on the outer wall of a plugging end of the taper plugging part; a locating convex rib is arranged on the inner wall of the taper plugging part; the television plug ferrule is an integral ferrule; a locating slot with an opening in the end surface is formed in the plugging end of the television plug ferrule; television plug ferrule is inserted into the plugging shell; and the locating convex rib is clamped in the locating slot to achieve locating and fixing. The television ferrule is simple in structure; the product cost is reduced; the assembly procedure is reduced; the assembly efficiency is improved; the connection reliability is improved; the connection stability is ensured; the applicability is high; and the practicability is good.
Owner:温州佰正仪表科技有限公司

Biped-walking dining car pushing robot

InactiveCN106347518ASuitable for useIncreased degree of humanoidManipulatorVehiclesHuman bodyEngineering
The invention discloses a biped-walking dining car pushing robot which comprises an upper body structure, a back, a lower body structure and a dining car, wherein the upper body structure comprises a main frame having an appearance simulating the shape of the upper body of a human body, and the main frame comprises a head part, shoulder parts and a chest part; the dining car comprises a framework body, three carrier layers are alternately arranged on the body uniformly from top to bottom, and wheels are arranged at four corners of the bottom of the body; a handrail is connected with the top of the rear part of the body; a double-stable dining delivery device is carried in every two carrier layers; and the lower body structure is arranged in a bilaterally symmetric manner, and comprises thigh structures, shank structures and foot structures. The biped-walking dining car pushing robot can simulate the human body to push the dining car and walk, simulate the knee bending action of the human body as well as simulate the action that the leg with a bent knee walks forward and the other leg does not walk temporarily, and is stable in dining delivery. The biped-walking dining car pushing robot has a relatively simple structure, is convenient to process and manufacture, has relatively low cost, and is suitable for restaurants for saving labor force and attracting more diners.
Owner:HENAN UNIVERSITY OF TECHNOLOGY

Human walking simulated plate carrying robot

InactiveCN106347517AIncreased degree of humanoidAvoid unstable phenomena such as pouringManipulatorVehiclesMarine engineeringWater holding
The invention discloses a human walking simulated plate carrying robot, comprising an upper body structure, a waist board, a lower body structure and a double-stable meal delivery device. The upper body structure is a frame type structure, and comprises a main frame. The main frame comprises a head portion, a shoulder portion and a thoracico-abdominal portion. The double-stable meal delivery device comprises a meal delivery bottom plate. A main container having an arched vertical section is arranged on the meal delivery bottom plate. A lead block is fixedly connected to the bottom of an inner cavity of the main container, and the center of gravity of the lead block is located right above a first ball. A water holding plate is arranged in the inner cavity of the main container above the lead block, and hermetically connected to the inner wall of the main container. The center of the water holding plate is upwardly connected with an elastic expansion link, and the top end of the elastic expansion link is fixedly connected to a second ball. The water holding plate and the main container define a water tank. The water tank is filled with water, and a tableware tray floats on the water, and comprises a disc-shaped tray bottom plate. The human walking simulated plate carrying robot is capable of simulating human walking, and also capable of avoiding unstable meal delivery, and is simple in structure and relatively low in manufacturing cost.
Owner:HENAN UNIVERSITY OF TECHNOLOGY

Method for reducing production of furan during fermented soybean processing

The present invention discloses a method for reducing production of furan in a fermented soybean product during fermented soybean processing. The method comprises: controlling the soybean cooking time, the soybean cooking temperature, the fermentation time, the fermentation temperature, and drying of the finished product. According to the present invention, the furan content during fermented soybean processing can be significantly reduced.
Owner:NANCHANG UNIV

Cooling pipe and cooling structure of mold

The invention provides a cooling pipe and a cooling structure of a mold. Operation for mounting into a cooling hole can be simplified, and meanwhile leakage of cooling fluid is not prone to happening.The cooling pipe inserted into the cooling hole formed in the mold comprises a pipe and a lip packing, wherein the pipe extends from the front end side to the rear end side along the axis, a groove recessed towards the inner side in the axis right-angle direction orthogonal to the axis is formed in the outer circumference, and the lip packing is arranged on the outer side in the axis right-angledirection of the bottom surface of the groove formed in the pipe; the groove has a first face facing the front end surface of the lip packing and a second face facing the rear end surface of the lip packing, the pipe is provided with a first portion and a second portion, a first face is formed at the rear end, a second face is formed at the front end, and the outer diameter of the outer peripheralsurface of the first portion is enlarged from the front end side to the rear end side.
Owner:株式会社阿雷斯提

Automobile seat for helping child to sleep

The invention discloses an automobile seat for helping a child to sleep. The automobile seat comprises a child seat body, a handle, a third buckle and an inserting block, the handle is arranged on theupper side surface of a supporting seat, fan-shaped check curtains are arranged on the left side surface and the right side surface of the supporting seat, meanwhile, the lower ends of the fan-shapedcheck curtains are connected with the supporting seat through connecting shafts, connecting elastic bands are arranged on the upper rear sides of the fan-shaped check curtains and are connected withthe child seat body through fixing screws, and clamping blocks are arranged on the front side surfaces of the fan-shaped check curtains. The automobile seat for helping the child to sleep is providedwith the fan-shaped check curtains, clamping blocks and connecting limiting pieces, so when the automobile seat for helping the child to sleep is used for making the child sleep, the clamping blocksare pulled to drive the fan-shaped check curtains to be unfolded, the clamping blocks are fixedly connected with the connecting limiting pieces, and therefore the fan-shaped check curtains are unfolded and fixed, the fan-shaped check curtains can play a role in shielding light, and the child is not prone to being affected during sleeping.
Owner:江苏悍威汽车有限公司

Low-noise efficient gas turbine exhaust system

The invention discloses a low-noise efficient gas turbine exhaust system, and relates to the technical field of gas turbine exhaust systems. A sound absorption layer is arranged between an outer pipeand an inner pipe. A slow flow device comprises a fixing rod arranged in the middle of the inner pipe, and multiple buffer parts are arranged on the fixing rod. The buffer parts comprise multiple arc-shaped buffer pieces, one ends of the arc-shaped buffer pieces are fixedly connected with the fixing rod, the other ends of the arc-shaped buffer pieces are away from the fixing rod, the outer sides of the arc-shaped buffer pieces are close to the fixing rod, the distances between the buffer parts are gradually increased from the ends close to an exhaust outlet to the other ends, and the widths ofthe arc-shaped buffer pieces are gradually increased from the ends close to the exhaust outlet to the other ends. A first sound reflecting layer is arranged on the inner wall of the outer pipe, and comprises multiple sequentially-connected arc-shaped sound reflecting pieces, and the inner sides of the sound reflecting pieces are arranged towards the middle of the inner pipe. Generation of noise is restrained from the source, the noise is absorbed externally, the noise is greatly lowered on the two aspects, and the influences of the noise on the environment are retarded.
Owner:江苏华强新能源科技有限公司

LED lamp

An LED lamp comprises a body, a radiating component, a light source component, a lateral cover, a diffusion sheet and a cover plate. The radiating component, the light source component, the lateral cover, the diffusion sheet and the cover plate are successively connected onto the body. A mounting position is arranged on the body and used for mounting the radiating component. The radiating component comprises a base and radiating fins connected onto the periphery of the base. A connection position is arranged on the base and used for connecting the light source component. The lateral cover surrounds the light source component and is fixed on the light source component. The diffusion sheet is fixed at one end, far away from the light source component, of the lateral cover. The cover plate cooperates with the body and is used for fixing the radiating component, the light source component, the lateral cover and the diffusion sheet between the cover plate and the body. The LED lamp has the advantages that heat generated by the light source component can be dispersed to the surrounding by the aid of the radiating component, and quick radiating of the LED lamp is achieved by means of air heat convection; the LED lamp is high in radiating efficiency and simple and practical in structure.
Owner:东莞市闻誉实业有限公司

Driving practice site mark pole

InactiveCN104575172ANot easy to leaveThere is no problem of damageTeaching apparatusEngineering
The invention discloses a driving practice site mark pole. The mark pole comprises a suspension frame (1). Tubular mark pole bodies (2) and ropes (3) are arranged on the lower portion of the suspension frame (1) and are perpendicular to the ground. The portion, pointed by the lower end of each mark pole body (2), of the ground is provided with a sunken tube (4). One end of each rope (3) is connected with a counter weight (5), and the other end of the counter weight (5) is connected to the lower end of the corresponding mark pole body (2). Each counter weight (5) is arranged in the corresponding sunken tube (4) and can move vertically in the sunken tube (4). The driving practice site mark pole has the advantages that the mark pole bodies (2) will not shake on a windy day. The mark pole bodies (2) can be made of light materials. More importantly, after being impacted by a vehicle, the mark pole bodies (2) are not prone to being separated from the vehicle due to the fact that the lower ends of the mark pole bodies (2) are drawn by the counter weights (5) in the sunken tubes (4), and namely, the problems that the mark pole impacts a vehicle repeatedly when falling off, and as a result, the vehicle is damaged is avoided; resetting is rapid.
Owner:宁波市奉化溪口金通熔接设备厂

Connection lamp holder

The invention discloses a connection lamp holder. The connection lamp holder comprises an insulation connector, wherein a pair of conductive metal sheets capable of connecting with external wires is arranged in the insulation connector, and a socket allowed for wire passing through is arranged on the insulation connector, wherein an insulating binding post is arranged on the insulation connector, and a through slot corresponding to the socket is arranged on the binding post. A wiring structure is arranged on one end of the conductive metal sheet, wherein the wiring structure can cut the insulating layer of the wires and contact the core wires of the wires when the wires are inserted into the binding post. The wires and the connection lamp holder can be connected in one time. According to the invention, the direct connection among the cut insulating layer of the wires, the core wires of the wires and the metal sheet can be formed once the wires are directly pushed into the connection lamp holder, and the connection is firm and stable. The connection lamp holder provided in the invention saves steps of fixing parts such as bolts and the like so as to provide advantages of convenience and rapidness. With the connection lamp holder, connection steps and operability of the connection lamp holder are greatly simplified.
Owner:JIANGMEN OPENWISE ELECTRICAL FACTORY GUANGDONG

Internet sensor connector

A disclosed internet sensor connector comprises a connector body and an insulating shell, the upper end and the lower end of the connector body are provided with a first interface and a second interface respectively, the insulating shell is arranged on the outer side of the connector body in a sleeving mode, and the insulating shell is composed of a fastening sleeve shell, a lower sleeve shell, atransition sleeve shell and an upper sleeve shell. The fastening sleeve shell is arranged on the outer side of the second interface in a sleeving mode, a plurality of oblique through holes are formedin the outer side face of the fastening sleeve shell, oblique arc guide plates are fixedly connected to one ends of the oblique through holes and located in the lower sleeve shell, and moving columnsare fixedly connected to the side faces of the upper ends of rubber rods. Through the arrangement of the oblique through holes, the oblique arc guide plates, the rubber rods and the moving columns, after the second interface is connected with connecting equipment, a moving lantern ring is pushed to enable the rubber rods to slide into the oblique through holes along the oblique arc guide plates, the rubber rods tightly abut against the inner side wall of an equipment connector, and then the internet sensor connector is not prone to being disengaged from the equipment connector.
Owner:SHENZHEN POLYTECHNIC

LED radiator

An LED radiator comprises a radiator body, a radiating component, a light source module, a side cover, a diffusion sheet and a cover plate, wherein the radiating component, the light source module, the side cover, the diffusion sheet and the cover plate are connected on the radiator body sequentially, the radiator body is provided with mounting positions for mounting the radiating component, the radiating component is connected with the light source module, the light source module comprises a PCB (printed circuit board) and a plurality of LED chips distributed on the PCB in a matrix arrangement manner, the side cover surrounds the light source module and is fixed thereon, the diffusion sheet is fixed at one end, distant from the light source module, of the side cover, and the radiating component, the light source module, the side cover and the diffusion sheet are arranged between the cover plate and the radiator body. The LED radiator has the advantages that heat generated by the light source module is rapidly diffused all around through the radiating component, and radiation of the LED radiator is rapidly achieved by means of air heat convection; the LED radiator is simple and practical in structure and easy to popularize.
Owner:东莞市闻誉实业有限公司

Water dispersible granule for prevention and control of molluscs and preparation method of water dispersible granule

The invention discloses a water dispersible granule for prevention and control of molluscs and a preparation method of the water dispersible granule. The water dispersible granule comprises the following ingredients by mass percentage: 0-85% of metaldehyde, 0-85% of niclosamide ethanolamine salt, 1-3% of wetting agent, 5-20% of emulsification dispersant, 0-5% of disintegrating agent, 0-10% of binding agent, 0.5% of defoaming agent, and a carrier to reach 100%, wherein the mass percentage of metaldehyde and the mass percentage of niclosamide ethanolamine salt cannot be 0% at the same time. The water dispersible granule is convenient to transport, lower in transportation cost, high in active ingredient content, good in dispersity, high in suspensibility and higher in storage stability; no dust is generated basically in a production process; the environmental control cost is low; the water dispersible granule is sprayed for application after the water dispersible granule is diluted with water; the residue of the water dispersible granule in an environment is reduced; the possibility of spray head blocking is low; no dust drift exists during use; the influence on an operator and the surrounding environment is smaller; and the possibility of hazards and environmental pollution is low.
Owner:广东农密生物科技有限公司

Wilson seal packingring and valve using same

The invention relates to a double-loop sealing ring, characterized in that it is the circular ring and grooves are set in the inside and outside of the ring; O-shaped rubber rings are embedded in the grooves respectively. The invention also provides a valve with mentioned double loop sealing ring, comprising valve and valve cover fixed with valve body. Valve bar extends into valve body through the hole opened on the valve cover. It is characterized in that double loop sealing ring is set on the valve bar; the outer O-shaped rubber ring is set against valve body and the inner O-shaped rubber ring is set against valve bar. The invention provides safe and reliable sealing ring for the location of valve bar in valve so as to improve the service life of valve and decrease the maintaining cost generated by frequently repairing and changing.
Owner:赵伟

Massaging machine

The present invention provides a massaging machine, capable of correctly measuring heartbeat or skin resistance of a curer under a condition that the curer body is relaxed, and performing massage corresponding to a stress response or a polycondensation state. A body information detection mechanism (30) is provided with a skin resistance detection part (60) for measuring the skin resistance and a heartbeat detection part (70) for measuring the heartbeat, which are arranged on a bar-shaped detection body (42) which may be grasped by the curer through left and right end parts. The detection body is provided with a first electrode (62) as the skin resistance detection part on one end, a second electrode (72) as the heartbeat detection part and a grounded third electrode (80), and a fourth electrode (74) as the heartbeat detection part on the other end. By means of grasping the left and right end parts of the detection body through left and right hands, the heartbeat and skin resistance may be measured correctly in a grounded state, and the stress response degree and polycondensation degree are judged according to the measured values so as to control a massaging mechanism.
Owner:SANYO ELECTRIC CO LTD +1

A kind of groundwaste

The invention belongs to the technical field of cleaning equipment, and in particular relates to a floor washing machine, comprising a body, a sewage box and a floor brush module; the body includes a first casing, a turret and a first rotating block; the sewage box It includes a sealing cover and a box body; the sealing cover is detachably fixed on the box body; the end of the box body close to the sealing cover is an open structure; the box body is detachably clamped on the box body On the floor brush module; the end of the box body close to the fuselage is provided with a sewage suction port; the end of the box body away from the fuselage is provided with a sewage inlet; the interior of the first shell is provided with a suction fan and a clean water tank; the suction fan is communicated with the sewage box and the floor brush module; the clean water tank is connected with the floor brush module through a water pump and a hose; through the above arrangement, the pipeline of the washing machine is not easy to Residual dirt, and easy cleaning, eliminates the risk of pipe blockage and odor.
Owner:SHENZHEN SHERMON TECH CO LTD

led radiator

An LED radiator comprises a radiator body, a radiating component, a light source module, a side cover, a diffusion sheet and a cover plate, wherein the radiating component, the light source module, the side cover, the diffusion sheet and the cover plate are connected on the radiator body sequentially, the radiator body is provided with mounting positions for mounting the radiating component, the radiating component is connected with the light source module, the light source module comprises a PCB (printed circuit board) and a plurality of LED chips distributed on the PCB in a matrix arrangement manner, the side cover surrounds the light source module and is fixed thereon, the diffusion sheet is fixed at one end, distant from the light source module, of the side cover, and the radiating component, the light source module, the side cover and the diffusion sheet are arranged between the cover plate and the radiator body. The LED radiator has the advantages that heat generated by the light source module is rapidly diffused all around through the radiating component, and radiation of the LED radiator is rapidly achieved by means of air heat convection; the LED radiator is simple and practical in structure and easy to popularize.
Owner:东莞市闻誉实业有限公司

Flame-retardant power cable

The invention provides a flame-retardant power cable, including a glass fiber high-temperature rope, a first wire core group, a second wire core group, a flame-retardant belt, a first filling layer, a flame-retardant inner lining layer, a shielding layer, an armor layer, a flame-retardant outer lining layer and an outer sheath. The first wire core group includes two first wire cores which are symmetrically arranged with the glass fiber high-temperature rope being the center; the second wire core group includes two second wire cores which are symmetrically arranged with the glass fiber high-temperature rope being the center; the flame-retardant inner lining layer is wrapped outside the first wire core group and the second wire core group, the first filling layer is filled among the flame-retardant inner lining layer, the first wire core group and the second wire core group, the flame-retardant belt is arranged inside the first filling layer and is wrapped outside the first wire core group and the second wire core group, the shielding layer is wrapped outside the flame-retardant inner lining layer, the armor layer is wrapped outside the shielding layer, the flame-retardant outer lining layer is wrapped outside the armor layer, and the outer sheath is wrapped outside the flame-retardant outer lining layer. The flame-retardant power cable provided by the invention has excellent mechanical property and flame-retardant property.
Owner:ANHUI WUZHOU SPECIAL CABLE GRP

A kind of preparation method of 6,6'-bis(2,3-dimethoxybenzoyl)-α,α-d-trehalose and its intermediate

The invention discloses a method for preparing a 6,6'-bi(2,3-dimethoxyphenyl)-alpha,alpha-D-trehalose intermediate. The method comprises the following steps: (1) dissolving 2,3-dimethoxybenzoic acid in anhydrous tetrahydrofuran, adding N,N'-carbonyl diimidazole, stirring at room temperature, and performing carboxyl activation; (2) adding a compound shown as a formula II and N-bromo-succinimide in a catalytic amount into the reaction solution subjected to carboxyl activation in the step (1), stirring and reacting; and (3) adding water into the solution reacted in the step (2), stirring for 10-15 minutes, extracting for three times by using dichloromethane, mixing the organic layers, washing for three times by using a saturated potassium carbonate aqueous solution, washing by using saturated salt, drying by using anhydrous sodium sulfate, filtering, concentrating, recrystallizing the residues by using ethanol / water, thereby obtaining the 6,6'-bi(2,3-dimethoxyphenyl)-alpha,alpha-D-trehalose intermediate, removing the trimethylsilyl of the intermediate under weakly acidic conditions, thereby obtaining 6,6'-bi(2,3-dimethoxyphenyl)-alpha,alpha-D-trehalose. The method disclosed by the invention is mild in reaction conditions, low in cost and suitable for industrial production.
Owner:济南美高生物医药科技有限公司

Combined jute blocking paster

The invention discloses a combined jute blocking paster. The combined jute blocking paster comprises a main body and a jute eyelet fabric covering the main body, wherein the main body comprises an outer blocking ring and an inner blocking ring; the outer blocking ring and the inner blocking ring are connected with each other and concentrically arranged; the outer blocking ring has a first cylindrical body group obliquely and upwardly extending towards the outer side of the outer blocking ring from the upper surface of the outer blocking ring; the inner blocking ring has a second cylindrical body group vertically and upwardly extending from the upper surface of the inner blocking ring; and the first cylindrical body group and the second cylindrical body group penetrate the jute eyelet fabric. According to the invention, the jute eyelet fabric sleeves the main body in a covering manner; the oblique first cylindrical body group penetrates the jute eyelet fabric and downwardly presses thejute eyelet fabric to restrain the jute eyelet fabric between the first cylindrical body group and an installing surface, so the jute eyelet fabric is difficult to be divorced from the first cylindrical body group; the second cylindrical body group extending vertically and upwardly allows water current to pass through and can hook hair flowing with water, so hair is collected to a place nearby thepaster.
Owner:长葛市英达麻纺织厂

An electrical signal transmission device for preventing electrodes from falling off

The invention discloses an electric signal transmission device for preventing electrodes from falling off, which includes a casing, the interior of which includes an electric signal transmission body, and a plurality of first springs arranged on one side of the interior of the casing, and several first springs. The springs are all separated by partitions, and the upper and lower ends of the first spring are provided with clamping ports, and the contraction air bag can be inflated when the electrode plug is inserted into the connection hole of the electrode end through the provided contraction air bag, so that The anti-slip ring wraps the electrode plug to fix the electrode. When the electrode plug is loose, the anti-slip ring wrapped around the electrode plug is driven by the electrode plug to move outward so that one end of the limiting plate leaves the inside of the first spring, and the limiting plate leaves the first spring. The internal contact port of the spring is simultaneously displaced to contact with the second electrical terminal on one side of the partition to be energized, so that the first indicator light electrically connected to the contact port is energized and illuminated, thereby performing a light warning.
Owner:广州通泽医疗科技有限公司

Hat arranged on clothes

The invention relates to a hat arranged on clothes. A peak of the hat is provided with a connecting belt, and the connecting belt passes through the face of people. The hat has the advantages that: 1) the hat is fixed through the connecting belt, the hat cannot easily fall off from the head of the human body in the wind, in addition, the connecting belt is in transverse arrangement, soft and warm keeping plus materials can be selected, the effect of fixing the hat is realized, and simultaneously, the warm keeping effect is also realized; and 2) one end of the connecting belt is fixed at one end of the hat, the other end of the connecting belt is connected with the other end of the hat through a magic tape, the connecting mode is simple, and in addition, the shape and the attractive appearance of the hat cannot be influenced.
Owner:朱永华

Method for preparing 6,6'-bi(2,3-dimethoxyphenyl)-alpha,alpha-D-trehalose and intermediates thereof

The invention discloses a method for preparing a 6,6'-bi(2,3-dimethoxyphenyl)-alpha,alpha-D-trehalose intermediate. The method comprises the following steps: (1) dissolving 2,3-dimethoxybenzoic acid in anhydrous tetrahydrofuran, adding N,N'-carbonyl diimidazole, stirring at room temperature, and performing carboxyl activation; (2) adding a compound shown as a formula II and N-bromo-succinimide in a catalytic amount into the reaction solution subjected to carboxyl activation in the step (1), stirring and reacting; and (3) adding water into the solution reacted in the step (2), stirring for 10-15 minutes, extracting for three times by using dichloromethane, mixing the organic layers, washing for three times by using a saturated potassium carbonate aqueous solution, washing by using saturated salt, drying by using anhydrous sodium sulfate, filtering, concentrating, recrystallizing the residues by using ethanol / water, thereby obtaining the 6,6'-bi(2,3-dimethoxyphenyl)-alpha,alpha-D-trehalose intermediate, removing the trimethylsilyl of the intermediate under weakly acidic conditions, thereby obtaining 6,6'-bi(2,3-dimethoxyphenyl)-alpha,alpha-D-trehalose. The method disclosed by the invention is mild in reaction conditions, low in cost and suitable for industrial production.
Owner:济南美高生物医药科技有限公司
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