The invention discloses an abrasion-proof and corrosion-resistant nickel-based alloy wire and a preparation method thereof. The alloy wire comprises the following components: 17-21% of C, 20-25% of Co, 1.8-2.2% of W, 6.4-9.5% of Mo, 1.4-1.8% of Al, 3.2-4.5% of Ti, 0.1-0.5% of Nb, 0.1-0.5% of Hf, 1.2-1.8% of Ta, 0.03-0.06% of Re, 0.01-0.05% of Ce, 0.02-0.1% of C, 0.005-0.015% of B, 0.02-0.07% of Zr, 0.005-0.008% of Mg, and the balance Ni. The preparation technology of the alloy comprises the steps of vacuum smelting, remelting, forging, hot rolling, drawing, solid solution treatment and aging treatment, namely, raw materials are prepared and smelted based on mass percent and then smelted; the smelted materials are forged and rolled into obtain alloyed wire rods; the alloyed wire rods are drawn at a plurality of times to obtain phi 0.05-0.4mm alloy wires; finally the alloy wires are subjected to solid solution treatment and aging treatment. The abrasion-proof and corrosion-resistant nickel-based alloy wire can be used as a brush wire material for brush sealing of an aircraft engine, a gas turbine, etc., thus the brush sealing effect can be effectively improved, and the service life can be prolonged.