The invention belongs to the technical field of substation equipment, and particularly relates to an intelligent vehicle-mounted mobile transformer substation. The transformer substation comprises a power transformation vehicle and a power distribution vehicle connected with the power transformation vehicle, and the power transformation vehicle comprises a power transformation vehicle body, an HGIS and a main transformer, and the HGIS is installed on the vehicle body; the power distribution vehicle comprises a power distribution vehicle body, a prefabricated cabin, an electrical secondary protection chamber and a medium-voltage power distribution chamber; a control cubicle is arranged on the HGIS of the power transformation vehicle; the control cubicle is provided with an in-situ protection and measurement and control device sub-machine I; the instrument terminal box is provided with an in-situ protection and measurement and control device sub-machine II; and a medium-voltage switch cabinet in the medium-voltage power distribution room is provided with an in-situ protection and measurement and control device sub-machine III, a measurement and control device sub-machine IV, a measurement and control device sub-machine V, a measurement and control device sub-machine VI and a measurement and control device sub-machine VII. The number of cables and the number of screen cabinets between two vehicles are effectively reduced, products are highly integrated, the transportation size is reduced, safety and reliability are achieved, field installation is easy, and the intelligence andreliability of the products are improved.