35results about How to "Restore functionality" patented technology

Nerve guides which are formed from three dimensional (3D) arrays of highly aligned electrospun fibers are provided. The electrospun fibers are oriented parallel to the long axis of the guide, and gaps and elongated spaces between the stacked fiber arrays provide channels for directed axonal growth. In some embodiments, the nerve guides also comprise high precision gradients of beneficial substances such as growth factors, which aid in nerve regeneration and growth along the guide.

A device for providing a magnetic treatment by evoking muscle contraction by a time-varying magnetic field and providing a RF treatment by heating biological structure. The device includes an applicator having an RF electrode and a magnetic field generating device. The device may also include a main unit, a human machine interface, and a control unit. The control unit adjusts a signal provided to the RF electrode and controls an RF circuit, and also adjusts the signal provided to the magnetic field generating device and controls a magnetic circuit electrically insulated from the RF circuit. The RF circuit may include a power source and a power amplifier, and the magnetic circuit may include an energy storage device to supply the magnetic field generating device with electric current.

The invention relates to the use of an anabolic amino acid derivative stimulus acting in combination with vitamin D for the manufacture of a medicament or nutritional composition for the prevention and / or treatment of a loss of any one of muscle mass, muscle strength, muscle function, and physical function, or any combination thereof, in a mammal.

A method of processing seals (20), like leaf seals, in which seals (20) an annular gap, formed between two coaxial, cylindrical surfaces, is sealed off in the axial direction by a multiplicity of individual, thin sealing elements (22; 22a, b) which, with an orientation deviating from the radial direction, extend transversely through the gap and are fixed at their end assigned to the one cylindrical surface and bear loosely with the other, free end against the other cylindrical surface. An improvement in the sealing geometry is achieved in a simple manner in that, for the uniform orientation of the free ends of the sealing elements (22; 22a, b), in a first step, the sealing elements (22, 22a, b) are brought to bear with their free ends against a coaxial cylindrical surface having a predetermined diameter (D) in such a way that they are subjected to a bending stress, and in that, in a second step, the sealing elements (22; 22a, b) subjected to the bending stress are subjected to a heat treatment in such a way that the bending stress is completely removed.

Provided are compositions and methods for the identification and treatment of ovarian cancers, such as small cell ovarian cancers, in particular small cell carcinoma of the ovary, hypercalcemic type (SCCOHT), which ovarian cancers are characterized by reduced SMARCA4 gene expression and / or protein function and, as a consequence, are sensitive to growth and / or survival inhibition by one or more compounds that restore SMARCA4 gene expression and / or protein function.

A method of processing seals (20), like leaf seals, in which seals (20) an annular gap, formed between two coaxial, cylindrical surfaces, is sealed off in the axial direction by a multiplicity of individual, thin sealing elements (22; 22a, b) which, with an orientation deviating from the radial direction, extend transversely through the gap and are fixed at their end assigned to the one cylindrical surface and bear loosely with the other, free end against the other cylindrical surface. An improvement in the sealing geometry is achieved in a simple manner in that, for the uniform orientation of the free ends of the sealing elements (22; 22a, b), in a first step, the sealing elements (22, 22a, b) are brought to bear with their free ends against a coaxial cylindrical surface having a predetermined diameter (D) in such a way that they are subjected to a bending stress, and in that, in a second step, the sealing elements (22; 22a, b) subjected to the bending stress are subjected to a heat treatment in such a way that the bending stress is completely removed.

The present disclosure relates to sensor systems for electronic ophthalmic devices. In certain embodiments, the sensor systems may comprise a first electrode configured to be selectively overlaid by one or more of an upper eyelid and a lower eyelid of a user, a second electrode configured to be selectively overlaid by one or more of an upper eyelid and a lower eyelid of a user, and a system controller cooperatively associated with the first electrode and the second electrode to receive a capacitance measurement therefrom, the system controller configured to determine a position of one or more of the upper eyelid and the lower eyelid in spatial coordinates based on the capacitance measurement received from the first electrode and the second electrode.

A procedure for regenerating cartilage in a patient's joint damaged by Osteoarthritis by transplanting autologous hematopoetic stem cells extracted from a human, preferably the same human. The procedure begins by screening to ensure that the patient is a suitable candidate, then preparation of the patient for the stem cell transplantation by a combined regimen of intra-articular injection to diminish inflammation and facilitate apoptotic cell clearance, plus subcutaneous injection of hematopoetic growth factor. The autologous hematopoetic stem cells are then purified by incubating a blood sample with magnetic polystyrene beads (Dynabeads™) coated with a monoclonal antibody specific for CD34 cell membrane antigen. The stem cells are separated from the blood sample using a magnetic particle separator, and washed through a plurality of washing substeps. The purified and separated stem cells are suspended in a particular transplant solution, and the transplant solution is injected into the patient's joint such that the purified and separated autologous hemotopoetic stem cells enter the patient's damaged joint, and regenerates. The transplant solution contains specific growth factors that direct the stem cells into the areas of damaged or absent cartilage, allowing the stem cells to differentiate into young chondrocytes. This produces new healthy cartilage with a high potential in restoring the integrity and functionality of the joint.

The invention discloses a stent for directional induction of neural stem cell differentiation and a preparation method thereof, and belongs to the field of polymer materials and biomedical engineering. The adhesion growth of cells is promoted by improving the hydrophilicity of a matrix material of the stent; a microgroove structure is constructed on the inner and outer surfaces of the stent material, and the function of directional induction of the differentiation is achieved; at the same time, the stent can further release biological active factors in the controlled mode and promote the adhesion and the growth of the stem cells after the directional differentiation. The stent has a good application prospect in neural stem cell transplantation.

The invention relates to an electromechanical-hydraulic piston actuator (2) for providing pressurized pressure medium for a brake system of a vehicle, comprising an electric motor (6) having a statorand a rotor (10), a rotation-translation gearing (32) which is driven in rotation by the electric motor (6) and which has a rotatable nut (40) and a threaded rod (48) that is prevented from rotating and mounted so as to be able to slide in its axial direction, a piston (50) coupled to the threaded rod (48) in the axial direction thereof, a hydraulic cylinder (58) with a hydraulic chamber (56) which is filled with pressure medium and into which the piston (50) can be displaced, by a translatory movement of the threaded rod (48), from a retracted piston position in the direction of an advanced piston position in order to pressurize the pressure medium and / or expel same from the chamber (56), and a hydraulic connection (60) which is connected to the chamber (56) and via which pressure mediumcan be expelled from the chamber (56), and a supporting structure (3) to which the electric motor (6), the rotation-translation gearing (32) and the hydraulic cylinder (58) are attached, there being provided, between the rotor (10) of the electric motor (6) and the nut (40), an isolation device (70) for piston-travel-controlled isolation of the rotary coupling.

An implant device for placement within a salivary gland duct having a first end adjacent a parotid gland and a second end adjacent a submandibular gland. The implant device comprises an elongate body having a lumen, and a first and a second plate offset from the proximal end of the elongate body. The first plate is located on one side of the elongate body and the second plate is located on the other side of the elongate body. The first plate includes a first and a second hole operable to suture the first plate to a location adjacent the parotid gland. The second plate includes a first and a second hole operable to suture the second plate to a location adjacent the submandibular gland.

The present invention refers to a composition comprising N-acetylcysteine and / or lysozyme; or N-acetylcysteine and microencapsulated gastroprotected lysozyme with probiotic bacteria for use in the pharmacological treatment of gastric hyperacidity. Said composition is capable of restoring the stomach's own barrier effect, which is lost during the pharmacological treatment of gastric hyperacidity, and of minimising the secondary effects due to said pharmacological treatment.

An I / O system having redundant removable and / or replaceable components. Each of the removable / replaceable components can be removed by displacement parallel to a common axis. An I / O device having an I / O base with a lock-out toggle to prevent installation of one or more I / O modules to the I / O base unless a ground screw has been secured to supporting structure.

A device for providing a magnetic treatment by evoking muscle contraction by a time-varying magnetic field and providing a RF treatment by heating biological structure. The device includes an applicator having an RF electrode and a magnetic field generating device. The device may also include a main unit, a human machine interface, and a control unit. The control unit adjusts a signal provided to the RF electrode and creates an RF circuit, and also adjusts the signal provided to the magnetic field generating device and creates a magnetic circuit electrically insulated from the RF circuit. The RF circuit may include a power source and a power amplifier, and the magnetic circuit may include an energy storage to supply the magnetic field generating device with electric current.

Provided are compositions and methods for the identification and treatment of ovarian cancers, such as small cell ovarian cancers, in particular small cell carcinoma of the ovary, hypercalcemic type (SCCOHT), which ovarian cancers are characterized by reduced SMARCA4 gene expression and / or protein function and, as a consequence, are sensitive to growth and / or survival inhibition by one or more compounds that restore SMARCA4 gene expression and / or protein function.

The present invention relates to the use of stimulators of anabolic amino acid derivatives acting in combination with vitamin D in the preparation for the prevention and / or treatment of any of muscle mass, muscle strength, muscle function and body function, or any combination thereof, in mammals Loss of use in pharmaceutical or nutritional compositions.

Nanocomposite materials are provided for attaching soft tissue to hard tissue of a mammalian subject. The materials include a biodegradable polymer network suffused with mineral nanoparticles. The nanocomposite materials have a surface structure that promotes the infiltration, adhesion and proliferation of cells such as osteoblasts and fibroblasts, and are useful to reconstruct enthesis tissue, such as a tendon bone insertion. Devices containing the nanocomposites and methods for implantation of the devices at a tendon-bone interface or ligament-bone interface are provided for reconstructive surgery.

Systems, methods, and other embodiments associated with multi-phase ceramic composites are described herein. Specifically, a multi-phase ceramic composite having a microstructure having at least one solid-state lubricant phase and at least one wear resistant material phase.

An I / O device includes an I / O base, at least two I / O modules supported on the I / O base, and a duplex terminal block assembly supported on the I / O base. The at least two I / O modules include a first I / O module and a second I / O module coupled to the duplex terminal block assembly in parallel. The duplex terminal block assembly can include connectors for connecting to a field device. The duplex terminal block assembly can include conductive structures for coupling the connectors with each of the first and second I / O modules. The duplex terminal block can be installed in a pair of ports in an I / O base to connect two I / O modules in parallel.

The invention discloses a high-ductility self-recovery cement-based material and a preparation method thereof, the cement-based material comprises cement mortar, SMA fibers and carbon black, and the mass ratio of SMA fibers to carbon black is 32: 5-96: 10. The preparation method of the high-ductility self-recovery cement-based material comprises the following steps: mixing the cement mortar with the carbon black, and adding the SMA fibers to obtain the high-ductility self-recovery cement-based material. The cement-based material disclosed by the invention has high ductility, can sensitively monitor the cracking condition, and can be self-recovered after cracking; the SMA fibers are uniformly dispersed by changing the feeding sequence, so that the prepared cement-based material has the characteristics of high ductility and multi-crack development of a common fiber cement-based material, and also has the capability of recovering part of cracks.

An I / O device includes an I / O base, at least two I / O modules supported on the I / O base, and a duplex terminal block assembly supported on the I / O base. The at least two I / O modules include a first I / O module and a second I / O module coupled to the duplex terminal block assembly in parallel. The duplex terminal block assembly can include connectors for connecting to a field device. The duplex terminal block assembly can include conductive structures for coupling the connectors with each of the first and second I / O modules. The duplex terminal block can be installed in a pair of ports in an I / O base to connect two I / O modules in parallel.

The invention relates to a shoe, and provides a child shoe convenient to wear and take off and simple in structure. The shoe achieves wearing and taking-off convenience and wearing comfort, and the practicality of the shoe is improved. The child shoe comprises a sole, a vamp arranged on the sole, and an elastic band. The vamp is formed by sequentially splicing a plurality of petal-shaped vamp sheets. At least part of the adjacent petal-shaped vamp sheets are not connected, penetrating holes are formed in the petal-shaped vamp sheets, and the elastic band sequentially penetrates through the penetrating holes in the petal-shaped vamp sheets to tighten the disconnected portions of all the petal-shaped vamp sheets.

A device for providing a magnetic treatment by evoking muscle contraction by a time-varying magnetic field and providing a RF treatment by heating biological structure. The device includes an applicator having an RF electrode and a magnetic field generating device. The device may also include a main unit, a human machine interface, and a control unit. The control unit adjusts a signal provided to the RF electrode and creates an RF circuit, and also adjusts the signal provided to the magnetic field generating device and creates a magnetic circuit electrically insulated from the RF circuit. The RF circuit may include a power source and a power amplifier, and the magnetic circuit may include an energy storage to supply the magnetic field generating device with electric current.

The invention discloses a high-ductility self-recovery cement-based composite column, which comprises a steel pipe and a self-recovery cement-based material poured in the steel pipe, wherein the self-recovery cement-based material comprises cement mortar, SMA fibers and carbon black, and the mass ratio of the SMA fibers to the carbon black is 32:5-96:10. The high-ductility self-recovery cement-based composite column can bear large deformation and is excellent in ductility and anti-seismic property; and carbon black is doped into a matrix and is combined with conductive SMA fibers, so that theconductivity of the matrix is improved, and the cracking condition can be sensitively detected by analyzing the change of resistivity after the material is cracked and recovered.

An I / O system having redundant removable and / or replaceable components. Each of the removable / replaceable components can be removed by displacement parallel to a common axis. An I / O device having an I / O base with a lock-out toggle to prevent installation of one or more I / O modules to the I / O base unless a ground screw has been secured to supporting structure.

The invention relates to a method for identifying at least one fault in a regeneration path (19) of a pneumatic system (1) in a motor vehicle. Said method, in which air is conducted from a regeneration air reservoir (6) through a desiccant cartridge (3) in order to regenerate the desiccant cartridge (3), is characterized in that at least one physical parameter (15) of the air is acquired in a component of the regeneration path (19), the at least one physical parameter (15) is analyzed by an arithmetic unit (14) in order for a fault to be identified, and the result (16) of the analysis is further processed. The invention also relates to an associated device.

The invention discloses a magnetic field interaction device of a magnetic resonance physiotherapy instrument. The magnetic field interaction device includes a pedestal, a strong magnetic ring and an inductor, the top of the pedestal is provided with a physiotherapy couch main couch body, the top of the physiotherapy couch main couch body is provided with a couch plate, the joint of the pedestal and the physiotherapy couch main couch body is provided with a sliding rail, one side of an end part of the sliding rail is provided with a drive motor, the top of the sliding rail is provided with a magnetic ring fixing plate, the magnetic ring fixing plate is slidably connected with the sliding rail, the top of the magnetic ring fixing plate is provided with a rotary magnetic disc motor, an end part of an output shaft of the rotary magnetic disc motor is connected with a rotary magnetic disc, one side of the rotary magnetic disc is provided with the strong magnetic ring, a first sliding grooveis arranged between the physiotherapy couch main couch body and the couch plate, and the strong magnetic ring is arranged inside the first sliding groove and is movably connected with the first sliding groove. The magnetic field interaction device of the magnetic resonance physiotherapy instrument enhances magnetic field resonance through a rotary magnetic field technology, so that multielement magnetic field adjustment enables the physiotherapy position of a magnetic resonance physiotherapy instrument user to be finer and effects are better.

The invention relates to a film coating method and clamp for a conductive non-metal oxide material. The clamp comprises a base, magnetic suction caps, buckles and an upper mold plate, wherein the base comprises a base main body, mold grooves and buckle grooves; the mold grooves are uniformly distributed in the base main body; the buckle grooves are formed in the edge of the base main body; the magnetic suction caps comprise film coating pieces, cap bodies and cylindrical magnets; the film coating pieces are arranged below the cap bodies; the cylindrical magnets are arranged in the cap bodies; buckles are arranged on the buckle grooves; the upper mold plate comprises an upper mold plate main body and clamping grooves; the buckles are connected with the buckle grooves and the clamping grooves respectively; and the magnetic suction caps are arranged between the base and the upper mold plate. According to the film coating method and clamp, partial film coating of the film coating pieces is achieved, a coating conducting film is defrosted rapidly, and the use scene of an automobile radar is increased; and the the film coating method and clamp are worthy of popularization.

A process for leak testing in fuel injection pumps that have a pump housing that can be plugged into a motor housing, in which an outlet of the fuel injection pump, which feeds into an annular chamber that is divided by sealing rings and is normally discharged by way of a line, is closed with a material in order to carry out a leak test. The material is plastically deformable and dissolves with the heating of the fuel, and due to its plasticity, produces a sealed closure of the annular chamber in relation to the interior of the fuel injection pump so that the annular chamber can be loaded with a testing pressure via the line.