30results about How to "Slows introduction" patented technology

A stent graft (5) comprises a tubular graft member (4), and a plurality of sloping stent members (3) substantially coaxial with and coupled to the tubular graft member (4). Each of the sloping stent members (3) comprises multiple uneven apexes characterizing a round tubular configuration with a distal end and a proximal end disposed about a longitudinal axis. The distal apexes of the sloping stent member (3) are arranged in substantially the same plane substantially horizontal to the longitudinal axis of the sloping stent member and the proximal apexes are arranged in a sloping plane oblique to the longitudinal axis.

A process is provided of introducing an RNA into a living cell to inhibit gene expression of a target gene in that cell. The process may be practiced ex vivo or in vivo. The RNA has a region with double-stranded structure. Inhibition is sequence-specific in that the nucleotide sequences of the duplex region of the RNA and of a portion of the target gene are identical. The present invention is distinguished from prior art interference in gene expression by antisense or triple-strand methods.

A process is provided of introducing an RNA into a living cell to inhibit gene expression of a target gene in that cell. The process may be practiced ex vivo or in vivo. The RNA has a region with double-stranded structure. Inhibition is sequence-specific in that the nucleotide sequences of the duplex region of the RNA and of a portion of the target gene are identical. The present invention is distinguished from prior art interference in gene expression by antisense or triple-strand methods.

A spreader insert for use with a surgical retractor is provided. The spreader insert includes a circular head with two or more downwardly extending blades. One end of each blade of the insert is rotatably fastened to the head of the insert, such that each blade can be tilted inwardly or extended outwardly from a central axis of the device. Suitable fasteners are provided to rotate the blades from a closed position in which the distal ends of the blades are almost touching each other in order to improve ease of introduction into the surgical field. In an open position, the blades rotate outwardly to hold body tissue in place. Alternatively, the entire spreader insert is machined from a hardenable steel tube, the blades of which are formed so that, when released, they spring outwardly to an open position.

Method for providing a subscription to an IP-based Multimedia Subsystem (IMS) for a first client of a packet-switched network is provided. The first client is identified by the same MSISDN number as a second, mobile client of a circuit-switched network. The method comprises the following steps: a) sending, by the first client, a register request to an IMS Server via the packet-switched network, b) sending, by the IMS server, a location query request to a register for the IMS user identities (HSS), c) requesting, by the register for the IMS user identities (HSS), the user subscription information of the circuit-switched network from the register for the circuit-switched network (HLR), d) sending, by the register for the circuit-switched network (HLR), to the register for the IMS user identities, the user subscription information of the second client, e) creating, by the register for the IMS user identities (HSS), a user IMS subscription information based on user subscription information of the second client.

This apparatus provides a means by and through which a children's bottle or sip cup can be secured to structural components, such as car seat headrest, utilizing a bottle holder, a tether, and a clip. The bottle holder is comprised of a flexible, insulating material that securely fits around said bottle in such a manner that it cannot be easily extracted by a child. Furthermore, the bottle holder helps maintain desired temperature of the liquid within the bottle through the utilization of insulating materials. The tether can be adjusted to variable desired lengths. The tether has attached to it, a clip with easily and quickly secures to many different structural components. The clip can be easily removed as well. The invention allows a child to drop or throw a bottle or cup without misplacing the bottle or cup. The caretaker or child simply grabs the tether which has the bottle or cup securely attached.

A deep channel type of radial ball bearing having a retainer. The bearing has an outer ring and an inner ring. Running channels are formed on the mutually opposing orbiting surfaces of the outer ring and inner ring. A specified number of balls are fit into the running channels. The retainer having pockets is placed between the outer ring and the inner ring. Each ball is captured in one of the pockets. A ball contact surface is formed on the inner surface of each edge on the opening side of the pockets. A curved ridge line forms the boundary between the inner surface of the pocket and the contact surface. This curved ridge line that forms the boundary is substantially parallel to the direction of rotation of the balls. A channel is formed at the bottom surface of the pocket. The channel extends from the inner perimeter to the outer perimeter of the retainer. The lubricating oil on the bottom surface of the pocket flows through the channel by virtue of the rolling of the balls and is guided to the outer perimeter side. A triangle-shaped fin having an inclined surface is integrally formed between the adjacent pockets on the outer perimeter surface. The inclined surface is formed on the trailing side of pocket with respect to the retainer direction of rotation. Lubricating oil directed from the above-described channel to the outer perimeter surface by the rolling of the ball is received at the inclined surface of the fin and is supplied to the vicinity of the leading edge of the pocket that is located behind the fin by the rotation of the retainer.

A method is provided for inducing or enhancing an immune response in a mammal to a target polypeptide expressed in a plurality of cells of the mammal, which method comprises administering to the mammal an inhibitory nucleic acid which targets a region of a ribonucleic acid (RNA) which encodes said polypeptide. Also provided is a pharmaceutical composition comprising an inhibitory nucleic acid which targets a region of an RNA which encodes a target polypeptide expressed in a plurality of cells of a mammal, such that translation of an aberrant form of the target polypeptide occurs in said cells, said truncated form of the target polypeptide comprising one or more T cell epitopes; together with a pharmaceutically acceptable carrier or diluent.

A method is provided for inducing or enhancing an immune response in a mammal to a target polypeptide expressed in a plurality of cells of the mammal, which method comprises administering to the mammal an inhibitory nucleic acid which targets a region of a ribonucleic acid (RNA) which encodes said polypeptide. Also provided is a pharmaceutical composition comprising an inhibitory nucleic acid which targets a region of an RNA which encodes a target polypeptide expressed in a plurality of cells of a mammal, such that translation of an aberrant form of the target polypeptide occurs in said cells, said truncated form of the target polypeptide comprising one or more T cell epitopes; together with a pharmaceutically acceptable carrier or diluent.

A fastener for fastening an attached or trim part to a support part includes a receptacle part having a pocket with a lateral opening and a guide slot, and a connecting part having at least one flange that can be introduced into the pocket through the lateral opening and having a fastening section. The fastening section has an opening to accommodate a retaining stud projecting from the support part. Located in the opening are latching fingers which can hold the retaining stud in place in the opening.

The present disclosure relates to 2-dimensional MXenes surface-modified with catechol derivatives, a method for preparing the same, MXene organic ink including the same, and use thereof (e.g. flexible electrodes, conducive cohesive / adhesive materials, electromagnetic wave-shielding materials, flexible heaters, sensors, energy storage devices). Particularly, the simple, fast, and scalable surface-functionalization process of MXenes using catechol derivatives (e.g. ADOPA) organic ligands significantly improves the dispersion stability in various organic solvents (including ethanol, isopropyl alcohol, acetone and acetonitrile) and produces highly concentrated organic liquid crystals of various MXenes (including Ti2CTx, Nb2CTx, V2CTx, Mo2CTx, Ti3C2Tx, Ti3CNTx, Mo2TiC2Tx, and Mo2Ti2C3Tx). Such products offer excellent electrical conductivity, improved oxidation stability, excellent coating and adhesion abilities to various hydrophobic substrates, and composite processability with hydrophobic polymers. This finding will lead to further studies on the structures, properties, and physics of the organic MXene liquid crystals and their practical applications.

The punching die of the invention has a head 22 held by positive engagement. The head 22 is held on the shaft 21 of the die 8 in that by means of plastic deformation, for instance by radial application of pressure, material is positively displaced radially inward, so that a protrusion 28 is embodied which rests over a large area on the wall of a recess 23. A more secure, more durable force transition is assured.

The present invention relates to a material supply for a tablet pressing machine with a rotor, which comprises a matrix disc. The matrix disc includes a plurality of arranged matrices. The material supply is provided to supply material which is to be tabletted to the matrices formed in the matrix disc. A further subject of the invention is a tablet pressing machine which comprises a material supply according to the invention, and also a method for cleaning such a tablet pressing machine.

The present invention relates to a material supply for a tablet pressing machine with a rotor which comprises a matrix disc. A plurality of matrices is arranged within the matrix disc. The material supply is provided to supply material which is to be tabletted to the matrices formed in the matrix disc. A further subject of the invention is a tablet pressing machine which comprises a material supply according to the invention.

A stent graft (5) comprises a tubular graft member (4), and a plurality of sloping stent members (3) substantially coaxial with and coupled to the tubular graft member (4). Each of the sloping stent members (3) comprises multiple uneven apexes characterizing a round tubular configuration with a distal end and a proximal end disposed about a longitudinal axis. The distal apexes of the sloping stent member (3) are arranged in substantially the same plane substantially horizontal to the longitudinal axis of the sloping stent member and the proximal apexes are arranged in a sloping plane oblique to the longitudinal axis.

The invention provides for a security mark (1) on a recyclable container (2), where the security mark (1) comprises an illustration (3) including a first part (4) printed in a first ink and second part (5) printed in a second ink. The reflectance of the first part (4) is between 0 and 20 percent in the visible spectrum having a wavelength up to 660 nm, making the first part (4) substantially fully visible in most of the visible spectrum and the reflectance of the first part (4) is above 80 percent in infrared light having a wavelength above 800 nm making the first part (4) substantially invisible in most of the infrared spectrum. The reflectance of the second part (5) is between 0 and 20 percent in light having a wavelength up to 800 nm making the second part (5) substantially fully visible in the visible spectrum and a first part (4) of the infrared spectrum up to 800 nm and the reflectance of the second part (5) is above 25 percent in infrared light having a wavelength above 960 nm making the second part (5) at least not fully visible in most of the infrared spectrum. A method for validating the authenticity of a security mark (1) on a recyclable container (2) is also disclosed.

For a simplified method for heating a pre-warmed muffle used for dental ceramics in a dental furnace, wherein a saving of time in heating before the pressing and also a parallel heating of the muffles should be made possible, the following steps are suggested: a) heating of the muffle to a maximal temperature (Tmax), which is above the pressing temperature (Tpress), in which pressing is carried out, b) possibly keeping the muffle at a maximal temperature (Tmax) during a first pause (t-1), c) cooling of the muffle to a minimal temperature (Tmin), which is at most as high as the pressing temperature (Tpress), and d) keeping the muffle at a minimal temperature (Tmin) during a second pause (t2). In addition, a corresponding control device for the dental furnace and a furnace equipped with this kind of control device are produced.

Improvements in and relating to devices for receiving liquid samples A device for receiving a liquid sample may form part of a micro sampling head for an instrument such as a spectrophotometer. The device receives a liquid sample to be analysed by a process involving the passing of electromagnetic radiation through the sample, and comprises a light inlet guide (20) for directing electromagnetic radiation into the sample, a light receiving element (23) situated in an opposed relationship to the guide and spaced from the guide by a fixed distance to define a fixed path length gap (21), which is, in use, filled with the sample. In use, radiation is passed from the light inlet guide to the light receiving element (23), and the path length of radiation through the sample is defined by the gap (23). The device is open or openable to allow a droplet of sample to be deposited directly in the gap.

With reference to FIG. 1A, the present invention provides a two-stroke internal combustion engine comprising: a piston (19) reciprocable within a cylinder (20); an exhaust port (23) allowing communication of the cylinder (20) with an exhaust passage (24), which port (23) is opened and closed by the piston during the reciprocal motion thereof; moveable shutter means (1) for varying the effective area of the exhaust port (23), which shutter means (1) varies the effective area cyclically in a timed relationship to the reciprocal motion of the piston (19) within the cylinder (20); a compression ratio variation mechanism (41) additional to and separate from the moveable shutter means (1) for varying a compression ratio of the cylinder (20); sensor means (12, 14, 34) for measuring one or more operating characteristics of the engine and for generating signals corresponding thereto; and a control unit (11) which processes the signals generated by the sensor means (12, 14, 34) and controls the motion of the shutter means (1) accordingly and control the effective area of the exhaust port (25) and controls the compression ratio variation mechanism (41) to independently vary the compression ratio of the cylinder (20).

A device for strengthening a card reader including a slot at least partly delimited by a base and two lateral walls and extending along a longitudinal direction, the slot being intended to receive a card moving along the longitudinal direction while bearing on the base, the device including a wire of substantially circular cross-section arranged at the level of the base and on which the card is intended to slide.

The present invention provides for a release system for delaying application of chemical reagents in a lateral-flow immunoassay. A chemistry release fiber comprising a permeable membrane and a chemical release agent is used to delay chemical reagent delivery to the indicator of a lateral-flow immunoassay. Also disclosed is the related method of delaying application of chemical reagents in a lateral-flow immunoassay.

Disclosed are O-protected compounds of the formula (I):wherein B is an optionally protected nucleobase, and R1-R3 are as described herein, wherein at least one of R1-R3 is —CH2—O—N═CHR. The compounds are useful as intermediates in oligonucleotide synthesis. Also disclosed is a method of preparing the compounds from nucleosides via a process comprising conversion of a hydroxyl group to a methylthiomethoxy group, and a method of preparing oligonucleotides such as RNA starting from the compounds. The —CH2—O—N═CHR group is stable during oligonucleotide synthesis and can be easily removed after synthesis via, for example, treatment with a base.

An accessory for a conventional espresso coffee machine wherein the espresso machine has a bottom surface, and the accessory comprises a left support portion having a left support portion rear end and a left support portion forward end and a right support portion having a right support portion rear end and a right support portion forward end is disclosed. A rear joining portion joins the left support portion rear end to the right support portion rear end. The rear joining portion, the left support portion and the right support portion are configured and dimensioned to define a space between the left support portion and the right support portion. The left support portion, the right support portion and the rear joining portion together form a unitary accessory body, the accessory body have a top surface. The top surface mates with the bottom surface of the espresso machine to form a stable assembly therewith.

An intracellular delivery vehicle of which surface is covered by a positive charge, an intracellular delivery complex in which a component or compound desired is loaded in the intracellular delivery vehicle, a temperature-sensitive probe comprising the intracellular delivery complex, and a method for measuring the intracellular temperature by the temperature-sensitive probe are disclosed. The intracellular delivery vehicle is useful on account of its capability of easily delivering the component or compound desired inside the cell without inhibiting cell proliferation.

Disclosed are O-protected compounds of the formula (I): wherein B is an optionally protected nucleobase, and R1-R3 are as described herein, a method of preparing such compounds, and a method of preparing oligonucleotides such as RNA starting from such compounds. The O-protected compounds have one or more advantages, for example, the 2′-O-protected compound is stable during the various reaction steps involved in oligonucleotide synthesis; the protecting group can be easily removed after the synthesis of the oligonucleotide, for example, by reaction with tetrabutylammonium fluoride; and / or the O-protected groups do not generate DNA / RNA alkylating side products, which have been reported during removal of 2′-O-(2-cyanoethyl)oxymethyl or 2′-O-[2-(4-tolylsulfonyl)ethoxymethyl groups under similar conditions.

A device (30) for strengthening a card reader (10) including a slot (12) at least partly delimited by a base (34) and two lateral walls (17) and extending along a longitudinal direction, the slot being intended to receive a card moving along the longitudinal direction while bearing on the base, the device including a wire (30) of substantially circular cross-section arranged at the level of the base and on which the card is intended to slide.

Method for providing a subscription to an IP-based Multimedia Subsystem (IMS) for a first client of a packet-switched network is provided. The first client is identified by the same MSISDN number as a second, mobile client of a circuit-switched network. The method comprises the following steps: a) sending, by the first client, a register request to an IMS Server via the packet-switched network, b) sending, by the IMS server, a location query request to a register for the IMS user identities (HSS), c) requesting, by the register for the IMS user identities (HSS), the user subscription information of the circuit-switched network from the register for the circuit-switched network (HLR), d) sending, by the register for the circuit-switched network (HLR), to the register for the IMS user identities, the user subscription information of the second client, e) creating, by the register for the IMS user identities (HSS), a user IMS subscription information based on user subscription information of the second client.