The invention discloses an electronic delivery receipt management system and method. The system comprises a dissolved oxygen sensing and monitoring unit, a vehicle information acquisition unit, a weighing sensing and monitoring unit, a temperature sensing and monitoring unit, a humidity sensing and monitoring unit, a PH value sensing and monitoring unit, a printing unit, a master controller unit,a receiver client side unit, a transport vehicle information acquisition unit, a receiver scale unit, a server unit, an alarm message sending unit, a web client side unit, a mobile phone APP client side unit and an information sharing unit. Electronic management of the delivery receipt is realized by mainly using the automation technology, and use of the conventional paper delivery receipt is changed so that the problem of guaranteeing the key information filling authenticity in cargo handover can be solved, the problem of long-term preservation of the transaction document of both transactionsides can be solved, the problem of contradiction caused by the change of the cargo value can be solved for the both transaction sides, the problem of tedious input operation of the cargo informationcan be solved for the receiver, the personnel working efficiency can be enhanced and the accuracy of the transaction information can be ensured.