The invention relates to the field of comprehensive energy system calculation and analysis, in particular to a heat supply pipeline dynamic simulation method based on differential transformation, which comprises the following steps of: S1, differentiating a pipeline partial differential equation by using a semi-discrete difference scheme with a total variation non-increasing property so as to convert the pipeline partial differential equation into an ordinary differential equation set; s2, converting an ordinary differential equation set into a linear recursion relational expression by using differential transformation; and S3, recursively solving a differential transformation coefficient of the state quantity of the ordinary differential equation set according to an initial value condition and a boundary value condition of the equation, obtaining an approximate analytical expression of each state quantity, and further obtaining a change track of each state quantity along with time. By means of the method, dispersion and dissipation errors in the heat supply pipeline simulation process can be effectively eliminated, meanwhile, due to the linear recursion characteristic of differential transformation, a solution with high time precision can be easily obtained, and therefore the accuracy and reliability of pipeline dynamic simulation are guaranteed.