Compounds that have antiallergic and / or anti-inflammatory properties and methods of making thereof are disclosed. These compounds can block MMRGPRX2 and prevent or reduce mast cells activation. Pharmaceutical formulations in a unit
dosage form suitable for the delivery of the compounds to a subject in need thereof are disclosed. The pharmaceutical formulations may include one or more active agents in addition to the compounds, such as one or more additional antiallergic and / or anti-inflammatory agents. The
pharmaceutical formulation can be administered by
oral administration, parenteral administration,
inhalation, mucosal administration, or a combination thereof. Methods for preventing or treating pseudo allergic reactions, pseudo allergic diseases, and / or pseudo inflammatory diseases, or treating or ameliorating one or more symptoms associated with a pseudo
allergic reaction, a pseudo allergic
disease, and / or a pseudo inflammatory
disease in a subject are also disclosed.