2 results about "Muscle fat" patented technology

The present disclosure belongs to the technical field of biomedicine, and specifically relates to a lipid compound for therapeutic delivery, an oligonucleotide delivery system, and a preparation method therefor and the use thereof. The present disclosure has the following advantage: the lipid compound for therapeutic delivery or a pharmaceutically acceptable salt, isomer, solvate or prodrug thereof of the present disclosure can be used in the preparation of an siRNA delivery system, thereby further improving the ability of siRNA to knock down target genes in tissues such as muscle, adipose tissue, and peripheral nerves. The lipid compound for therapeutic delivery or the pharmaceutically acceptable salt, isomer, solvate or prodrug thereof provided in the present disclosure is expected to provide a new strategy for siRNA delivery to muscle, adipose tissue, nervous system, etc.

This invention discloses the application of ornithine aspartate in the preparation of drugs for treating systemic aging. By applying ornithine aspartate to regulate the systemic aging process, this invention can effectively improve hepatocyte dysfunction, restore cell proliferation activity, alleviate cell cycle arrest, and reduce the abnormal expression of aging-related genes and proteins in multiple tissues and organs such as the liver, kidneys, heart, muscles, and fat, thereby delaying the aging process. This technical solution can significantly improve the structural disorder and lipid deposition in aging liver tissue, reduce serum transaminase levels, improve liver function, reduce insulin resistance, inhibit the overexpression of SASP-related inflammatory factors, and maintain metabolic homeostasis. Furthermore, it effectively improves aging phenotypes in multiple tissues and organs. Therefore, this invention has significant technical effects and application potential in delaying systemic aging and improving motor function and metabolic abnormalities.