23 results about "Muscle fat" patented technology

The invention belongs to the technical field of medical image artificial intelligence and body composition analysis, and particularly relates to an MRI-based whole body muscle fat quality evaluation system, which comprises an MRI image data acquisition module, an image preprocessing module, an AI segmentation module, a quantitative calculation module, a database comparison module and a visual report generation module, according to the scheme, an improved U-Net framework is adopted, a KAN layer is embedded behind each Stage of a Swin Transform backbone network, fixed nonlinear activation in a traditional MLP is replaced, high-precision and interpretable modeling of local strength changes is achieved, and the boundary recognition capacity is remarkably improved; according to the scheme, a multi-level fusion mechanism combining SDI and KAN is introduced, the mechanism effectively strengthens a tissue related region and inhibits irrelevant or noise response, high-order nonlinear correction is performed on fused features by using a KAN layer, and complex intensity distribution at a muscle-fat junction is accurately described.

The utility model provides a ruminant living body muscle adipose tissue minimally invasive sampling device, which relates to the technical field of animal tissue sampling, and comprises an outer sleeve and an inner cutting rod, one end of the outer sleeve is provided with a needle, the other end of the outer sleeve is provided with a handle, and the outer sleeve is provided with a sampling groove close to the needle; the inner cutting rod is movably arranged in the outer sleeve, and a sampling knife is correspondingly arranged at the sampling groove. The animal sampling device has the advantages of being high in sampling efficiency, capable of reducing animal injuries, convenient, easy and fast to operate and low in cost.

The present application relates to the microRNA drug technical field, specifically to the application of hsa-let-7f-5p in the preparation of a drug for treating muscle steatosis, and discloses that hsa-let-7f-5p can inhibit muscle fat infiltration by inhibiting fibroblast / adipogenic progenitor cell adipogenic differentiation, and hsa-let-7f-5p can be used as a microRNA drug in the treatment of diseases such as muscle fat infiltration and muscle steatosis, and diseases related to fat infiltration, for example, muscle atrophy, muscle injury, obesity, diabetes, etc. The relevant nucleic acid fragments are wrapped in liposomes, so that the drug stability and drug efficiency can be improved. The technical scheme can solve the technical problem that there is no drug capable of effectively inhibiting muscle steatosis and treating muscle injury in the prior art, and has an ideal application and promotion prospect in the fields of sports medicine and rehabilitation treatment.

The application discloses a kind of screening methods and application of pivot gene related to sheep muscle fatty acid content, to solve the technical problems that local sheep breed sample quantity is limited, traditional single gene analysis method is difficult to analyze fatty acid metabolism regulation from network level.This application carries out transcriptome sequencing to multiple months of muscle tissue of Gangba sheep, constructs gene expression matrix, using weighted gene co-expression network analysis (WGCNA) Combined with module characteristic gene and fatty acid phenotype correlation screening strategy, the pivot gene significantly positively correlated with muscle fatty acid content is obtained.The screening method can construct a robust co-expression network under limited sample size, systematically identify the functional module and core gene related to the content of fatty acids such as linoleic acid, and reveal the dynamics of fatty acid metabolism at different ages, and the method can be extended to other plateau livestock;The screened pivot gene can be used as a molecular breeding marker for early selection of Gangba sheep, and the breeding cycle is shortened.

The invention discloses application of vitamin K in preparation of a medicine for treating paravertebral muscle adiposis of obese patients. The core of the application is to reverse fat infiltration in paravertebral muscles (such as multifidus muscle, erector spine muscle and lumbar major muscle) of an obese patient, so that the structure and function of a vertebral endplate are improved, the stability of the spine is enhanced, and degeneration of the spine intervertebral disc of the obese patient is relieved. The method has the advantages of non-invasiveness, high safety and the like, and is suitable for treating lumbago diseases related to long-term obesity management and paravertebral muscle adiposis.

The invention discloses a bacillus subtilis strain for producing amide compounds and application of the bacillus subtilis strain. The preservation number of the bacillus subtilis DZNBS-11-032 is CGMCC (China General Microbiological Culture Collection Center) NO.29593, and the preservation number of the bacillus subtilis DZNBS-11-032 is CGMCC NO.29593. The invention provides bacillus subtilis DZNBS-11-032 capable of generating amide compounds, and the bacillus subtilis DZNBS-11-032 is added into a feed for culturing crisped grass carps, so that the content of amino acids in muscle fat and the content of highly unsaturated fatty acids can be increased, and the interest of people in the application of the bacillus subtilis in the culture of the crisped grass carps can be stimulated.

The invention relates to the technical field of microRNA (Ribonucleic Acid) medicines, in particular to an application of hsa-miR-16-5p in preparation of a medicine for treating muscle injury. The invention discloses that the hsa-miR-16-5p has the function of inhibiting the expression of the Tgfbr3 gene, and the repair of muscle injury can be realized; the function of inhibiting fibroblast / adipogenic progenitor cell adipodifferentiation is also achieved, then muscle fat infiltration and muscle fat degeneration are inhibited, and the effect of further promoting muscle injury repair is achieved. As a microRNA drug, the microRNA drug can be used in muscle injury repair, muscle fat infiltration or muscle fatty degeneration can be effectively inhibited, and meanwhile, promotion of muscle injury repair is realized by regulating and controlling a signal channel in which Tgfbr3 participates. According to the technical scheme, the technical problem that RNA drugs capable of effectively treating muscle injuries are lacked in the prior art can be solved, and the RNA drugs have ideal application and popularization prospects.

This invention discloses a fully automated system for analyzing body tissue composition in chest CT scans, relating to the technical field of medical diagnostic equipment. The system automatically selects L1 slices that meet the requirements and quantitatively analyzes the muscle and fat area and density at the target level. The system specifically comprises three modules: a positioning module for locating the target L1 slice on the chest CT image; a segmentation module for segmenting the skeletal muscle and adipose tissue corresponding to the L1 axial slice on the chest CT image; and an automatic measurement module for automatically measuring body composition in clinical chest CT images. In summary, this invention not only improves the efficiency and accuracy of measuring body composition on chest CT scans, but also fills a gap in previous automated screening of single L1 slices.

The invention provides slow-release sarafloxacin hydrochloride soluble powder and a preparation method thereof, and belongs to the field of sarafloxacin preparations. The preparation method of the slow-release sarafloxacin hydrochloride soluble powder comprises the following steps: preparing composite drug-loaded particles, preparing microcapsules and carrying out post-treatment. According to the slow-release sarafloxacin hydrochloride soluble powder and the preparation method thereof, on the premise of effectively releasing medicine components, residual medicine in livestock and poultry bodies is rapidly metabolized and discharged, and residues of sarafloxacin in body tissues such as muscles and fat after livestock and poultry take the slow-release sarafloxacin hydrochloride soluble powder are reduced; stable and lasting release of the active ingredients in a target area is realized, and the bioavailability is improved; the stability of the soluble powder and sarafloxacin contained in the soluble powder is further improved, and good slow release performance can be kept after long-term storage.

Provided is a method performed by an apparatus for reading a shoulder disorder, the method including acquiring medical data including a shoulder image; preprocessing the acquired medical data; inputting the preprocessed medical data into a pre-trained neural network model to read a tear state of a rotator cuff; and generating result information on the medical data based on the read tear state of the rotator cuff.

The invention provides a breeding method for improving fish muscle fat content and application, and belongs to the technical field of gene editing breeding. The breeding method for improving the fish muscle fat content comprises the steps that a gene editing technology is adopted for knocking out osteomodulatory protein genes of fishes, so that the osteomodulatory protein genes form frame-shift mutation or early translation termination, and osteomodulatory protein gene mutants are obtained. According to the breeding method for increasing the fish muscle fat content, the osteomodulatory protein gene of the fish is knocked out in a gene editing mode, the fish muscle fat content can be remarkably increased, and the growth of the fish is not affected. The osteomodulatory protein gene can be used as a gene target of genetic breeding and gene editing breeding, and a breeding method for increasing the muscle fat content of fish based on the gene target can be applied to fish breeding and has important significance for cultivating new fish varieties with high muscle fat content.

This invention discloses a method for preparing a whole-body rabbit nerve specimen, comprising the following steps: S1, skinning and preservation: Skinning a rabbit carcass, separating the visceral nerves, removing the viscera, and then performing preservation treatment to obtain sample 1; S2, softening: Immersing sample 1 sequentially in a low-temperature softening enzyme EB solution, a mixed solution of hydrochloric acid and glycerol, and an alkaline solution to obtain sample 2; S3, nerve separation: Taking sample 2, removing muscle, fat, and bone, and separating the whole-body rabbit nerves; S4, defatting: Immersing the whole-body rabbit nerves sequentially in a sodium hydroxide solution and petroleum ether for defatting treatment to obtain sample 3; S5, bleaching and fixation: Bleaching sample 3 in hydrogen peroxide, then washing and drying to obtain sample 4; Fixing sample 4 onto a substrate in the upright posture of the rabbit to obtain the whole-body rabbit nerve specimen. This invention is simple to operate, and the resulting whole-body rabbit nerve specimen is easy to preserve and has a complete and aesthetically pleasing structure.

The invention relates to the technical field of microRNA medicines, in particular to application of hsa-let-7f-5p in preparation of a medicine for treating muscle fatty degeneration. The invention discloses that hsa-let-7f-5p can be used for inhibiting muscle fat infiltration by inhibiting adipose differentiation of fibroblast / adipogenesis progenitor cells. The hsa-let-7f-5p can be used as a microRNA drug, and is applied to the treatment of muscle fat infiltration and muscle fat degeneration diseases, and fat infiltration-related diseases, such as muscle atrophy, muscle injury, obesity, diabetes and the like. Related nucleic acid fragments are wrapped in the lipidosome, so that the drug stability and the drug delivery efficiency can be improved. According to the technical scheme, the technical problem that medicines capable of effectively inhibiting muscle fatty degeneration and treating muscle injury are lacked in the prior art can be solved, and the medicine has ideal application and popularization prospects in the fields of sports medicine, rehabilitation treatment and the like.

The invention discloses an application of fat powder as a chicken feed raw material in replacing corn and improving muscle fatty acid composition. The fat powder accounts for 2-6% of the feed; the dosage ratio of unsaturated fatty acid to saturated fatty acid is 2.7-3.83; in the fat powder, the saturated fatty acid accounts for 70-135 mg / g; 270 to 365 parts of unsaturated fatty acid; the unsaturated fatty acid comprises 1.03 to 2.56 parts of palmitoleic acid; 90.8 to 124 parts of oleic acid; 164 to 216 parts of linoleic acid; 0.819 to 1 part of eicosaenoic acid; 10 to 15.9 parts of alpha-linolenic acid; ePA (ethylene propylene diene monomer) is 1.49 to 3.24; and DHA (docosahexaenoic acid) 1.62- The fat powder is finely blended to replace corn and improve the composition of muscle fatty acid, so that the quality of chicken breast can be obviously improved, and the feed cost is obviously improved.

The present disclosure belongs to the technical field of biomedicine, and specifically relates to a lipid compound for therapeutic delivery, an oligonucleotide delivery system, and a preparation method therefor and the use thereof. The present disclosure has the following advantage: the lipid compound for therapeutic delivery or a pharmaceutically acceptable salt, isomer, solvate or prodrug thereof of the present disclosure can be used in the preparation of an siRNA delivery system, thereby further improving the ability of siRNA to knock down target genes in tissues such as muscle, adipose tissue, and peripheral nerves. The lipid compound for therapeutic delivery or the pharmaceutically acceptable salt, isomer, solvate or prodrug thereof provided in the present disclosure is expected to provide a new strategy for siRNA delivery to muscle, adipose tissue, nervous system, etc.

A lipid oligonucleotide conjugate, an intermediate thereof, the use thereof and a pharmaceutical composition thereof. The lipid oligonucleotide conjugate can be used for the delivery of a variety of non-hepatic organs or tissue, including but not limited to muscles, fat, CNS, lungs, eyes, heart, etc., so as to achieve the treatment of diseases in the non-hepatic field.

The invention discloses mandarin fish feed capable of increasing the muscle fat content of mandarin fish and application of the mandarin fish feed. The mandarin fish feed capable of improving the muscle fat content of mandarin fish comprises a basic mandarin fish feed, and a mixture of 2-hydroxyisobutyric acid and S-adenosylmethionine is added; wherein the 2-hydroxyisobutyric acid accounts for 0.2-0.6% of the mass fraction of the basic mandarin fish feed; the mass fraction of the S-adenosylmethionine in the basic mandarin fish feed is 0.4-0.9%. According to the mandarin fish feed, a commercially available basic mandarin fish feed is used as a base material, a mixture of 2-hydroxyisobutyric acid and S-adenosylmethionine is added, and after all the raw materials are matched according to a certain proportion, the 2-hydroxyisobutyric acid and the S-adenosylmethionine are subjected to synergistic interaction, fat synthesis related genes are up-regulated, meanwhile, fat decomposition related genes are inhibited, and the content of fat in the mandarin fish feed is increased. The accumulation of fat in muscles is promoted.

The invention discloses an innocent treatment device for dead livestock and poultry, belongs to the technical field of solid waste treatment, and aims to solve the problems that high-temperature and high-pressure steam needs to slowly permeate from the surfaces of dead livestock and poultry when a wetting machine is used because the whole dead livestock and poultry are compact in corpse epidermis and compact in muscle, fat and visceral tissue texture; the invention relates to a harmless treatment device, in particular to a harmless treatment device for a dead body, and aims to solve the problems that the existing harmless treatment device is difficult to quickly penetrate to a core area in the dead body, so that a sterilization dead angle is easily formed, the harmless treatment efficiency is reduced, and meanwhile, incomplete sterilization and insufficient chemical treatment are easily caused. According to the invention, uniform and through steam channels can be formed in the whole dead bodies of livestock and poultry died of diseases, high-temperature and high-pressure steam is sprayed from inside to outside, sterilization dead angles are avoided, sterilization thoroughness is improved, meanwhile, a traditional pre-crushing procedure is omitted, the epidemic disease diffusion risk is reduced from the source, and the innocent treatment efficiency and epidemic prevention safety are synchronously improved.

The present invention belongs to the field of microbial technology and specifically relates to a strain of Bacillus coagulans that produces highly unsaturated fatty acids and its applications. The purpose of the present invention is to increase the content of highly unsaturated fatty acids in the muscle fat of farmed animals. The technical solution of the present invention is a strain of Bacillus coagulans (DZNBC-11-068), which has a deposit number of CGMCC No. 29595. The Bacillus coagulans of the present invention efficiently produces highly unsaturated fatty acids during its growth and metabolism. In animal application tests, the strain was able to colonize the intestines, improving the absorption efficiency of highly unsaturated fatty acids in farmed animals, thereby promoting the content of highly unsaturated fatty acids in the muscle fat of farmed animals.

The invention relates to the field of in-vitro culture and induced differentiation of animal cells, in particular to a culture medium for rapid and synchronous myobiogenesis and adipogenesis serum-free co-induction of fish stem cells and an induction method. According to the method, a serum-free induction culture medium containing specific components is used, nutrition, metabolism and fatty acid delivery conditions required by muscle cell fusion and lipid droplet formation are met in the same induction system at the same time, the process complexity and batch-to-batch fluctuation caused by step-by-step induction are reduced, stable construction of the muscle-lipid composite tissue is achieved, and the method is suitable for large-scale popularization and application. Controllable supply and spectral pattern adjustment of key fatty acid components such as DHA and EPA are supported; synchronous differentiation is started when the cell fusion degree reaches the specified standard, and finally the fish-derived muscle-fat composite tissue with mature muscle fibers and fat droplets at the same time is obtained.

This invention discloses the application of ornithine aspartate in the preparation of drugs for treating systemic aging. By applying ornithine aspartate to regulate the systemic aging process, this invention can effectively improve hepatocyte dysfunction, restore cell proliferation activity, alleviate cell cycle arrest, and reduce the abnormal expression of aging-related genes and proteins in multiple tissues and organs such as the liver, kidneys, heart, muscles, and fat, thereby delaying the aging process. This technical solution can significantly improve the structural disorder and lipid deposition in aging liver tissue, reduce serum transaminase levels, improve liver function, reduce insulin resistance, inhibit the overexpression of SASP-related inflammatory factors, and maintain metabolic homeostasis. Furthermore, it effectively improves aging phenotypes in multiple tissues and organs. Therefore, this invention has significant technical effects and application potential in delaying systemic aging and improving motor function and metabolic abnormalities.

The invention discloses application of an antioxidant in preparation of a medicine for treating fat infiltration and fibrosis related diseases after rotator cuff injury, and belongs to the technical field of medicines. SD rat rotator cuff injury model research finds that vitamin C and N-acetylcysteine have dual core effects after rotator cuff injury: 1, muscle fiber atrophy, fibrosis hyperplasia and local inflammatory response of skeletal muscle after injury are improved, and muscle fat infiltration is remarkably inhibited; 2, the anti-oxidation defense capability of the body is enhanced, the expression of antioxidant genes such as superoxide dismutase (SOD1, SOD2 and SOD3) and peroxide reductase (PRDX5) is promoted, the activity of antioxidant enzyme is improved, and the oxidative stress level is effectively relieved. The antioxidant provided by the invention can simultaneously improve fat infiltration, fibrosis, muscle atrophy and local chronic inflammation after rotator cuff injury and regulate oxidative stress, is expected to reduce the risk of postoperative retearing and promote functional recovery, and has a wide application prospect.

The application discloses application of ornithine aspartate in preparation of a medicine for treating systematic aging, and the ornithine aspartate is used to regulate the systematic aging process of a body, so that the liver cell dysfunction can be effectively improved, cell proliferation activity can be recovered, cell cycle arrest can be reduced, abnormal expression of aging-related genes and proteins in multiple tissues and organs such as liver, kidney, heart, muscle and fat can be reduced, and the aging process can be delayed. The technical scheme can significantly improve structural disorder and lipid deposition of the aging liver tissue, reduce the serum transaminase level, improve the liver function, reduce insulin resistance, inhibit excessive expression of SASP-related inflammatory factors, and maintain metabolic homeostasis. And the aging phenotype in multiple tissues and organs can be effectively improved. Therefore, the application has significant technical effects and application potential in delaying systematic aging, improving exercise function and metabolic abnormalities.