The invention discloses a full-automatic single-head mill which comprises a frame, a longitudinal moving assembly, a transverse moving assembly, a lifting assembly, a spindle box assembly, a tool magazine, a pneumatic control system, a water supply assembly and a Programmable Logic Controller (PLC) intelligent control system. The longitudinal moving assembly is arranged on the frame and comprises two longitudinal moving portions and a beam, and the two longitudinal moving portions are respectively fixedly connected with two ends of the beam. The transverse moving assembly is arranged on the beam. The lifting assembly is erected on the transverse moving assembly. The tool magazine is fixed below the beam, and a plurality of millstones are arranged on the tool magazine. The spindle box assembly is fixedly arranged on the lifting assembly. The water supply assembly is connected with the spindle box assembly to supply cooling water. The PLC intelligent control system and the pneumatic control system are arranged on one side of the longitudinal moving assembly, and the PLC intelligent control system is connected with the longitudinal moving assembly, the transverse moving assembly, the lifting assembly, the spindle box assembly, the tool magazine, a pneumatic control system circuit and the water supply assembly.