The invention discloses a quaternary pyridine salt type alkaline or weak alkaline polymer membrane, which is used as a membrane material of a direct alcohol fuel cell. The quaternary pyridine salt type alkaline or weak alkaline polymer membrane is produced from polymer materials which are subjected to membrane formation, quaternization reaction and alkalization reaction. The polymer materials are polymer materials produced by pyridine quaternization and a blend prepared from the polymer materials and polyvinylidene fluoride, bisphenol A polyether sulfone, polyether-ether-ketone, polyether sulfone, polyethersulfoneketone, poly(phthalazinone ether ketone), poly(phthalazinone ether sulfone) or poly(phthalazinone ether sulfone ketone) and so on which are blended. A direct methanol fuel cell (AMDMFC) adopting the quaternary pyridine salt type alkaline or weak alkaline polymer membrane works under alkaline or weak alkaline conditions, has the advantages of improving the oxidation reaction rate of methanol, eliminating the methanol permeation caused by electric dragging, widening the selection range of catalysts (including the catalysts of anodes and cathodes) and cell materials, simplifying water management and so on.