The invention relates to a traditional Chinese medicine technology and the technical field of microbial fermentation engineering, and discloses a traditional Chinese medicine preparation capable of effectively preventing myocardial infarction, cerebral infarction and pulmonary embolism and a preparation method. The traditional Chinese medicine preparation comprises the following raw materials in parts by weight: 20-40 parts of codonopsis pilosula, 25-40 parts of rhizoma atractylodis macrocephalae, 25-55 parts of astragalus membranaceus, 8-23 parts of rhizoma cimicifugae, 20-80 parts of radix aconiti carmichaeli, 25-45 parts of rhizoma zingiberis, 18-40 parts of rhizoma curcumae longae, 8-15 parts of cassia twig, 15-30 parts of the root of red-rooted salvia, 15-25 parts of pseudo-ginseng, 25-45 parts of liquorice, 15-30 parts of prepared rhizome of rehmannia, 30-45 parts of fructus lycii, 15-30 parts of morinda officinalis, 15-30 parts of scutellaria baicalensis, 20-35 parts of carapax trionycis, 20-35 parts of oyster shell, 2-5 parts of compound microbial strain, 800-1100 parts of water, 10-25 parts of starch, and 3-7 parts of glucose. The invention can provide the traditional Chinese medicine capable of strengthening yang qi, promoting blood circulation to remove blood stasis, and softening hardness to dissipate stagnation and used for performing enzymolysis on thrombus, purifying blood, softening blood vessel, activating a sweat gland system, enhancing metabolism, and discharging lipid and waste in the blood vessel from bodies through sweat pores.