The invention discloses a 
fermentation production method of tobacco leaves. The tobacco leaves after 
threshing and redrying or the tobacco leaves after primary 
drying and arranging are carried out the resurgence till the 
water content reaches 16 percent to 22 percent, the 
fermentation is carried out for 3 days under the conditions of the temperature of 25 DEG C to 40 DEG C and the 
humidity of 70 percent to 90 percent, the tobacco leaves are further dried till the 
water content reaches 11 percent to 13 percent, and the process is repeated for 180 to 700 days. The method inspires the activity of biological enzymes in the tobacco leaves which are not passivated, the 
fermentation is simultaneously carried out along with the non-enzymatic oxidation and the microbial effect, and the rapid alcoholization of the tobacco leaves is carried out through the control of the temperature and the 
humidity. Compared with the naturally alcoholized and the alcoholized tobacco leaves by adding the biological enzymes, the contents of the 
protein, the 
nicotine and 
tar of the obtained tobacco leaves are lower, and the contents of the fragrant substances and the 
reducing sugar are higher. The types of the fragrant substances are more, the 
aroma is natural and delicate, and the 
smoke is alcoholized. The fermentation production method is characterized by simple operation, low cost and strong operationality, regulation and 
controllability, thereby facilitating the realization of the large-scale industrial production.